ATE459003T1 - Verfahren zur bestimmung der selektivität von botulinum toxin - Google Patents
Verfahren zur bestimmung der selektivität von botulinum toxinInfo
- Publication number
- ATE459003T1 ATE459003T1 AT05767609T AT05767609T ATE459003T1 AT E459003 T1 ATE459003 T1 AT E459003T1 AT 05767609 T AT05767609 T AT 05767609T AT 05767609 T AT05767609 T AT 05767609T AT E459003 T1 ATE459003 T1 AT E459003T1
- Authority
- AT
- Austria
- Prior art keywords
- selectivity
- determining
- neuromuscular blocking
- blocking substance
- synaptic neuromuscular
- Prior art date
Links
- 108030001720 Bontoxilysin Proteins 0.000 title 1
- 229940053031 botulinum toxin Drugs 0.000 title 1
- 230000000903 blocking effect Effects 0.000 abstract 4
- 230000002232 neuromuscular Effects 0.000 abstract 4
- 230000003518 presynaptic effect Effects 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 4
- 210000002460 smooth muscle Anatomy 0.000 abstract 3
- 210000003699 striated muscle Anatomy 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0661—Smooth muscle cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0417366A GB2416849A (en) | 2004-08-04 | 2004-08-04 | Method for determining the quantity of a pre-synaptic neuromuscular blocking substance in a sample |
| PCT/GB2005/003032 WO2006013354A1 (en) | 2004-08-04 | 2005-08-02 | Method for determining the selectivity of a pre-synaptic neuromuscular blocking substance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE459003T1 true ATE459003T1 (de) | 2010-03-15 |
Family
ID=32982512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05767609T ATE459003T1 (de) | 2004-08-04 | 2005-08-02 | Verfahren zur bestimmung der selektivität von botulinum toxin |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8759093B2 (de) |
| EP (1) | EP1776589B1 (de) |
| AT (1) | ATE459003T1 (de) |
| DE (1) | DE602005019575D1 (de) |
| GB (1) | GB2416849A (de) |
| WO (1) | WO2006013354A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102639054B (zh) | 2009-11-18 | 2015-02-18 | 梅斯制药两合股份有限公司 | 梭菌神经毒素的定量检测方法 |
| JP5624672B2 (ja) * | 2010-04-15 | 2014-11-12 | カーディアック ペースメイカーズ， インコーポレイテッド | 断続的神経刺激による過渡反応を使用する自律神経調節 |
| ES2653249T3 (es) | 2011-09-29 | 2018-02-06 | Cellsnap, Llc | Composiciones y métodos para ensayos de toxigenicidad |
| AU2014301116B2 (en) | 2013-06-28 | 2019-11-14 | Merz Pharma Gmbh & Co. Kgaa | Means and methods for the determination of the biological activity of Neurotoxin polypeptides in cells |
| CN114621921A (zh) * | 2020-12-11 | 2022-06-14 | 深圳先进技术研究院 | 一种提取神经突触体的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2398636A (en) * | 2003-02-21 | 2004-08-25 | Ipsen Ltd | Method for determining the quantity of pre-synaptic neuromuscular blocking substance contained in a sample |
-
2004
- 2004-08-04 GB GB0417366A patent/GB2416849A/en not_active Withdrawn
-
2005
- 2005-08-02 EP EP05767609A patent/EP1776589B1/de not_active Expired - Lifetime
- 2005-08-02 US US11/659,445 patent/US8759093B2/en not_active Expired - Fee Related
- 2005-08-02 AT AT05767609T patent/ATE459003T1/de not_active IP Right Cessation
- 2005-08-02 WO PCT/GB2005/003032 patent/WO2006013354A1/en not_active Ceased
- 2005-08-02 DE DE602005019575T patent/DE602005019575D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1776589A1 (de) | 2007-04-25 |
| GB2416849A (en) | 2006-02-08 |
| EP1776589B1 (de) | 2010-02-24 |
| WO2006013354A1 (en) | 2006-02-09 |
| GB0417366D0 (en) | 2004-09-08 |
| US8759093B2 (en) | 2014-06-24 |
| DE602005019575D1 (de) | 2010-04-08 |
| US20080213820A1 (en) | 2008-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |