ATE4588T1 - Antiarrhythmische tetrahydronaphthalinderivate. - Google Patents

Antiarrhythmische tetrahydronaphthalinderivate.

Info

Publication number
ATE4588T1
ATE4588T1 AT80304050T AT80304050T ATE4588T1 AT E4588 T1 ATE4588 T1 AT E4588T1 AT 80304050 T AT80304050 T AT 80304050T AT 80304050 T AT80304050 T AT 80304050T AT E4588 T1 ATE4588 T1 AT E4588T1
Authority
AT
Austria
Prior art keywords
antiarhythmic
tetrahydronaphthaline
derivatives
tetrahydronaphthaline derivatives
antiarhythmic tetrahydronaphthaline
Prior art date
Application number
AT80304050T
Other languages
English (en)
Inventor
Frederic P. Hauck
Rita T. Fox
Original Assignee
E.R. Squibb & Sons, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E.R. Squibb & Sons, Inc. filed Critical E.R. Squibb & Sons, Inc.
Application granted granted Critical
Publication of ATE4588T1 publication Critical patent/ATE4588T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C07D303/26—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds having one or more free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
AT80304050T 1979-11-13 1980-11-12 Antiarrhythmische tetrahydronaphthalinderivate. ATE4588T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9365479A 1979-11-13 1979-11-13
EP80304050A EP0028940B1 (de) 1979-11-13 1980-11-12 Antiarrhythmische Tetrahydronaphthalinderivate

Publications (1)

Publication Number Publication Date
ATE4588T1 true ATE4588T1 (de) 1983-09-15

Family

ID=22240065

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80304050T ATE4588T1 (de) 1979-11-13 1980-11-12 Antiarrhythmische tetrahydronaphthalinderivate.

Country Status (17)

Country Link
EP (1) EP0028940B1 (de)
JP (1) JPS5686140A (de)
AR (1) AR228579A1 (de)
AT (1) ATE4588T1 (de)
AU (1) AU543557B2 (de)
CA (1) CA1148152A (de)
DE (1) DE3064775D1 (de)
DK (1) DK482080A (de)
ES (1) ES8200860A1 (de)
GR (1) GR72294B (de)
HU (1) HU182233B (de)
IE (1) IE50341B1 (de)
IT (1) IT1218431B (de)
NO (1) NO152372C (de)
NZ (1) NZ195470A (de)
PT (1) PT72050B (de)
ZA (1) ZA806871B (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787767A (fr) * 1971-08-21 1973-02-19 Merck Patent Gmbh Procede de preparation d'amides d'acides oxocarboxyliques et d'acides oxocarboxyliques
GB1559987A (en) * 1975-11-06 1980-01-30 Squibb & Sons Inc 1,2,3,4-tetrahydronaphthalene derivatives
AT350539B (de) * 1976-02-09 1979-06-11 Squibb & Sons Inc Verfahren zur herstellung von neuen 4-(3-subst. amino-2-hydroxpropoxy)-5,6,7,8-tetrahydro- 1,6,7-naphthalintriolen

Also Published As

Publication number Publication date
AR228579A1 (es) 1983-03-30
DE3064775D1 (en) 1983-10-13
JPS5686140A (en) 1981-07-13
EP0028940A1 (de) 1981-05-20
EP0028940B1 (de) 1983-09-07
ES496749A0 (es) 1981-11-16
GR72294B (de) 1983-10-18
HU182233B (en) 1983-12-28
NO803413L (no) 1981-05-14
CA1148152A (en) 1983-06-14
NO152372B (no) 1985-06-10
PT72050B (en) 1981-09-24
ES8200860A1 (es) 1981-11-16
NO152372C (no) 1985-09-18
DK482080A (da) 1981-05-14
NZ195470A (en) 1984-05-31
AU543557B2 (en) 1985-04-26
IE50341B1 (en) 1986-04-02
PT72050A (en) 1980-12-01
IT1218431B (it) 1990-04-19
AU6413880A (en) 1981-05-21
ZA806871B (en) 1981-10-28
IT8048374A0 (it) 1980-04-09
IE802351L (en) 1981-05-13

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee