ATE45290T1 - Applikator zur nicht-invasiven, transkutanen verarbreichung eines medikamentes. - Google Patents

Applikator zur nicht-invasiven, transkutanen verarbreichung eines medikamentes.

Info

Publication number
ATE45290T1
ATE45290T1 AT84109840T AT84109840T ATE45290T1 AT E45290 T1 ATE45290 T1 AT E45290T1 AT 84109840 T AT84109840 T AT 84109840T AT 84109840 T AT84109840 T AT 84109840T AT E45290 T1 ATE45290 T1 AT E45290T1
Authority
AT
Austria
Prior art keywords
applicator
medication
invasive
transcutaneous administration
layers
Prior art date
Application number
AT84109840T
Other languages
English (en)
Inventor
Den Sibalis
Original Assignee
Drug Delivery Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drug Delivery Systems Inc filed Critical Drug Delivery Systems Inc
Application granted granted Critical
Publication of ATE45290T1 publication Critical patent/ATE45290T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/044Shape of the electrode

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
AT84109840T 1983-08-18 1984-08-17 Applikator zur nicht-invasiven, transkutanen verarbreichung eines medikamentes. ATE45290T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/524,252 US4557723A (en) 1983-08-18 1983-08-18 Applicator for the non-invasive transcutaneous delivery of medicament
EP84109840A EP0147524B1 (de) 1983-08-18 1984-08-17 Applikator zur nicht-invasiven, transkutanen Verarbreichung eines Medikamentes

Publications (1)

Publication Number Publication Date
ATE45290T1 true ATE45290T1 (de) 1989-08-15

Family

ID=24088425

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84109840T ATE45290T1 (de) 1983-08-18 1984-08-17 Applikator zur nicht-invasiven, transkutanen verarbreichung eines medikamentes.

Country Status (10)

Country Link
US (1) US4557723A (de)
EP (1) EP0147524B1 (de)
JP (1) JPS6060860A (de)
KR (1) KR930005050B1 (de)
AT (1) ATE45290T1 (de)
AU (1) AU563137B2 (de)
BR (1) BR8404119A (de)
CA (1) CA1224993A (de)
DE (1) DE3479294D1 (de)
MX (1) MX158181A (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
US4731926A (en) * 1985-02-19 1988-03-22 Drug Delivery Systems Inc. Method of manufacturing disposable and/or replenishable transdermal drug applicators
US4856188A (en) * 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
US5135477A (en) * 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
GB2175207B (en) * 1985-05-20 1989-07-05 Nabil Ibraham Rizk Improvements in or relating to implantable electrophoretic pumps
DE3586595T2 (de) * 1985-06-10 1993-04-08 Drug Delivery Systems Inc Programmierbare kontrolle und bausystem eines verabreichungsgeraetes fuer transdermische arzneien.
EP0225871B1 (de) * 1985-06-10 1990-03-14 Drug Delivery Systems Inc. Anlage und verfahren zur steuerung der elektrokinetischen lieferungsgeschwindigkeit einer arznei
DE3533230A1 (de) * 1985-09-18 1987-03-26 Ruediger Prof Dr Groening Transdermale arzneiformen mit verbesserter biologischer verfuegbarkeit der wirkstoffe
JPH066171B2 (ja) * 1985-11-15 1994-01-26 美智士 谷 生薬を使用した電気的刺激治療装置
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
AU597890B2 (en) * 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4886489A (en) * 1986-03-19 1989-12-12 Jacobsen Stephen C Flow-through methods and apparatus for iontophoresis application of medicaments at a controlled pH
US4915685A (en) * 1986-03-19 1990-04-10 Petelenz Tomasz J Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange
US4752285B1 (en) * 1986-03-19 1995-08-22 Univ Utah Res Found Methods and apparatus for iontophoresis application of medicaments
JPS62268569A (ja) * 1986-05-19 1987-11-21 株式会社アドバンス イオントフオレ−ゼ用リザ−バ電極
IE60941B1 (en) * 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device
US4911688A (en) * 1986-07-15 1990-03-27 Patent Research And Development Corp. Fluid containing covers - with electrical circuits
US4734090A (en) * 1986-07-18 1988-03-29 Drug Delivery Systems Inc. Electrical transdermal drug applicator
US4725263A (en) * 1986-07-31 1988-02-16 Medtronic, Inc. Programmable constant current source transdermal drug delivery system
JPS63102768A (ja) * 1986-10-20 1988-05-07 山之内製薬株式会社 イオントフオレ−シス用の新規プラスタ−構造体
JPS63135179A (ja) * 1986-11-26 1988-06-07 立花 俊郎 薬物の経皮投与具
US4822334A (en) * 1986-12-04 1989-04-18 Robert Tapper Electrical dosimetry control system
US4940456A (en) * 1987-02-10 1990-07-10 Dan Sibalis Electrolytic transdermal delivery of proteins
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
CA1317522C (en) * 1987-03-20 1993-05-11 Dan Sibalis Transdermal drug delivery system
US5163899A (en) * 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US4787888A (en) * 1987-06-01 1988-11-29 University Of Connecticut Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)
US4865582A (en) * 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators
JPH0197475A (ja) * 1987-10-09 1989-04-14 Watanabe Wataru 電気治療器
EP0398960B1 (de) * 1988-01-21 1995-12-06 Massachusetts Institute Of Technology Molekültransport durch gewebe mit der verwendung von elektroporation
WO1989006989A1 (en) * 1988-01-29 1989-08-10 The Regents Of The University Of California Iontophoretic non-invasive sampling or delivery device
US5362307A (en) * 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5162042A (en) * 1988-07-05 1992-11-10 Alza Corporation Electrotransport transdermal system
US4978337A (en) * 1988-09-08 1990-12-18 Alza Corporation Formulation chamber with exterior electrotransport delivery device
US5147296A (en) * 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
AU628419B2 (en) * 1988-10-26 1992-09-17 Hisamitsu Pharmaceutical Co. Ltd. Interface for electric endermism
US5332577A (en) * 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
US5241925A (en) * 1988-12-27 1993-09-07 Dermamed Apparatus and techniques for administering veterinary medicaments
IT1224045B (it) * 1988-12-29 1990-09-26 Alberico Benedicenti Veicolatore elettronico portatile
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
ATE146087T1 (de) * 1989-10-23 1996-12-15 Theratech Inc Vorrichtung für iontophorese unter verwendung einer durchfluss-kontrollierenden membran
US5324521A (en) * 1989-12-18 1994-06-28 Dermamed Systems for transdermal administration of medicaments
DE69133328T2 (de) * 1990-03-30 2004-07-29 Alza Corp., Palo Alto Vorrichtung zur iontophoretischen verabreichung
US6004309A (en) 1990-03-30 1999-12-21 Alza Corporation Method and apparatus for controlled environment electrotransport
US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
ES2082973T3 (es) * 1990-03-30 1996-04-01 Alza Corp Dispositivo para administracion iontoforetica de farmacos.
US5160741A (en) * 1990-07-06 1992-11-03 Alza Corporation Reduction or prevention of skin irritation by drugs
US5130139A (en) * 1990-07-06 1992-07-14 Alza Corporation Reduction or prevention of skin irritation by drugs
US5087241A (en) * 1990-07-24 1992-02-11 Empi, Inc. Iontophoresis electrode with reservoir and injection site
US5120545A (en) * 1990-08-03 1992-06-09 Alza Corporation Reduction or prevention of sensitization to drugs
US5149539A (en) * 1990-08-03 1992-09-22 Alza Corporation Reduction or prevention of sensitization to drugs
US5380271A (en) * 1992-09-24 1995-01-10 Alza Corporation Electrotransport agent delivery device and method
USD357742S (en) 1992-12-31 1995-04-25 Alza Corporation Electrotransport drug delivery system
FR2709670B1 (fr) * 1993-09-10 1995-10-20 Asulab Sa Dispositif en trois modules pour l'administration transdermique de médicaments par électrophorèse ou iontophorèse.
JP2818999B2 (ja) * 1993-11-22 1998-10-30 ドラッグ デリバリー システムズ インコーポレイテッド 経皮薬剤アプリケータ
JP3822635B2 (ja) * 1994-09-30 2006-09-20 ヴァイテリス インコーポレイテッド 改良されたイオン浸透式薬剤投与装置
US5961483A (en) * 1996-06-19 1999-10-05 Sage; Burton H. Iontophoretic delivery of cell adhesion inhibitors
DE69826124T3 (de) 1997-06-30 2007-10-11 Institut Gustave Roussy Verabreichung der nukleinsäure in den quergestreiften muskel
CN1261808A (zh) 1997-06-30 2000-08-02 罗纳-布朗克罗莱尔股份有限公司 向多细胞真核生物的细胞中转移核酸的改进方法和用于实施该方法的组合
US6163720A (en) * 1997-12-18 2000-12-19 Alza Corporation Layered rate controlling membranes for use in an electrotransport device
CN1606461B (zh) * 2001-10-24 2011-03-23 纸型电池有限公司 一种用制剂作皮肤治疗的装置、一种成套器具及皮肤贴片
US7349733B2 (en) * 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
EP1647232B1 (de) 2001-12-03 2011-08-17 Ekos Corporation Katheter mit mehreren Ultraschall-abstrahlenden Teilen
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
WO2005063331A1 (ja) * 2003-12-26 2005-07-14 Hisamitsu Pharmaceutical Co., Inc. 用時活性化型イオントフォレーシスデバイス
US20050197554A1 (en) * 2004-02-26 2005-09-08 Michael Polcha Composite thin-film glucose sensor
US8386029B2 (en) 2005-03-31 2013-02-26 Encore Medical Asset Corporation Apparatus for electrotherapy drug delivery with added impurities
US9072476B2 (en) * 2005-09-23 2015-07-07 Medtronic Minimed, Inc. Flexible sensor apparatus
CA2650412C (en) * 2006-04-13 2016-09-27 Nupathe, Inc. Transdermal methods and systems for the delivery of anti-migraine compounds
USD574962S1 (en) * 2006-05-23 2008-08-12 Sarah Atkins Adhesive gel pad
USD576282S1 (en) 2006-06-16 2008-09-02 Activatek, Inc. Adhesive transdermal medicament patch
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
ES2471118T3 (es) 2007-06-22 2014-06-25 Ekos Corporation Método y aparato para el tratamiento de hemorragias intracraneales
CA2724949A1 (en) * 2007-06-27 2008-12-31 The General Hospital Corporation Method and apparatus for optical inhibition of photodynamic therapy
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
US7981106B2 (en) * 2008-02-26 2011-07-19 Pinchas Gilad Electronically-controlled device for release of drugs, proteins, and other organic or inorganic chemicals
EP2100850A1 (de) 2008-03-11 2009-09-16 Stichting Voor De Technische Wetenschappen Mikronadelarray und Verfahren zur Mikronadelherstellung
FR2950802B1 (fr) 2009-10-02 2012-02-03 Sartorius Stedim Biotech Sa Elaboration et/ou conservation d'un produit biopharmaceutique.
WO2011046927A1 (en) * 2009-10-13 2011-04-21 Nupathe,Inc. Transdermal methods and systems for the delivery of rizatriptan
USD632400S1 (en) * 2010-06-11 2011-02-08 Jerad Bludorn Soft tissue adhesion rupturing tool
USD632399S1 (en) * 2010-06-11 2011-02-08 Jerad Bludorn Soft tissue adhesion rupturing tool
US9950143B2 (en) 2012-02-07 2018-04-24 Marie Andrea I. Wilborn Intravenous splint cover and associated methods
US20130204190A1 (en) * 2012-02-07 2013-08-08 Marie-Andrea I. Wilborn Intravenous splint cover and associated methods
USD790071S1 (en) * 2015-10-19 2017-06-20 Mölnlycke Health Care Ab Wound dressing
US10656025B2 (en) 2015-06-10 2020-05-19 Ekos Corporation Ultrasound catheter
CN109289116A (zh) * 2018-09-28 2019-02-01 胡希龙 养生保健护腰
USD1037441S1 (en) * 2022-04-05 2024-07-30 Avent, Inc. Tube securing device base

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US486902A (en) * 1892-11-29 Galvanic body-battery
US385567A (en) * 1888-07-03 Chables d
US385556A (en) * 1888-07-03 Medicated electric belt
US588479A (en) * 1897-08-17 Atjguste roedel
US2493155A (en) * 1947-01-09 1950-01-03 Mine Safety Appliances Co Apparatus for treating skin diseases
US2667162A (en) * 1950-05-03 1954-01-26 Zwahlen Henry Device permitting the ambulatory ionization of blood circulatory troubles of the lower limbs
US2784715A (en) * 1953-03-25 1957-03-12 Kestler Otto Colman Cataphoresis unit
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
US3289671A (en) * 1963-09-11 1966-12-06 Troutman Edwin Glenn Iontophoresis method
US3547107A (en) * 1968-02-27 1970-12-15 Robert L Chapman Chest mounted heart tachycardia detector
US4008721A (en) * 1975-04-14 1977-02-22 Medtronic, Inc. Tape electrode for transmitting electrical signals through the skin
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4325367A (en) * 1977-06-13 1982-04-20 Robert Tapper Iontophoretic treatment apparatus
US4273135A (en) * 1977-08-19 1981-06-16 Minnesota Mining And Manufacturing Company Biomedical electrode
US4239046A (en) * 1978-09-21 1980-12-16 Ong Lincoln T Medical electrode
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4243052A (en) * 1979-01-08 1981-01-06 Stimtech, Inc. Disposable electrode
DE2902183A1 (de) * 1979-01-20 1980-07-31 Geb Schmidt Beate D Ringwelski Vorrichtung zum aufbringen bzw. halten von nitrit- und/oder nitratverbindungen auf der haut
US4314554A (en) * 1979-07-16 1982-02-09 Greatbatch W Tissue growth control apparatus and method
US4367745A (en) * 1980-05-27 1983-01-11 Minnesota Mining And Manufacturing Company Conformable electrically conductive compositions
US4419091A (en) * 1981-02-12 1983-12-06 Sybron Corporation Metalized medical treatment electrode with insulated edge
US4416274A (en) * 1981-02-23 1983-11-22 Motion Control, Inc. Ion mobility limiting iontophoretic bioelectrode
EP0060452B1 (de) * 1981-03-05 1985-10-23 Medtronic, Inc. Iontotherapeutisches Gerät
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
JPS58130054A (ja) * 1982-01-29 1983-08-03 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体

Also Published As

Publication number Publication date
AU563137B2 (en) 1987-06-25
JPS6060860A (ja) 1985-04-08
BR8404119A (pt) 1985-07-16
EP0147524B1 (de) 1989-08-09
CA1224993A (en) 1987-08-04
MX158181A (es) 1989-01-13
EP0147524A1 (de) 1985-07-10
JPH0456627B2 (de) 1992-09-09
KR930005050B1 (ko) 1993-06-15
DE3479294D1 (en) 1989-09-14
KR850001702A (ko) 1985-04-01
US4557723A (en) 1985-12-10
AU3185084A (en) 1985-02-21

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Legal Events

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