ATE45167T1 - Muramyl-peptid- und steroid-derivate mit makrophagen aktivierenden eigenschaften. - Google Patents
Muramyl-peptid- und steroid-derivate mit makrophagen aktivierenden eigenschaften.Info
- Publication number
- ATE45167T1 ATE45167T1 AT84401681T AT84401681T ATE45167T1 AT E45167 T1 ATE45167 T1 AT E45167T1 AT 84401681 T AT84401681 T AT 84401681T AT 84401681 T AT84401681 T AT 84401681T AT E45167 T1 ATE45167 T1 AT E45167T1
- Authority
- AT
- Austria
- Prior art keywords
- macrophage activating
- activating properties
- steroid derivatives
- muramyl peptide
- steroid
- Prior art date
Links
- 150000003431 steroids Chemical class 0.000 title abstract 3
- 230000003213 activating effect Effects 0.000 title abstract 2
- 210000002540 macrophage Anatomy 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000010415 tropism Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8313333A FR2551758B1 (fr) | 1983-08-16 | 1983-08-16 | Derives de muramyl-peptides et de steroides ayant des proprietes d'activation des macrophages |
| EP84401681A EP0139554B1 (de) | 1983-08-16 | 1984-08-16 | Muramyl-Peptid- und Steroid-Derivate mit makrophagen aktivierenden Eigenschaften |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE45167T1 true ATE45167T1 (de) | 1989-08-15 |
Family
ID=9291628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84401681T ATE45167T1 (de) | 1983-08-16 | 1984-08-16 | Muramyl-peptid- und steroid-derivate mit makrophagen aktivierenden eigenschaften. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4663311A (de) |
| EP (1) | EP0139554B1 (de) |
| JP (1) | JPS60126297A (de) |
| AT (1) | ATE45167T1 (de) |
| AU (1) | AU588219B2 (de) |
| CA (1) | CA1257584A (de) |
| DE (1) | DE3479215D1 (de) |
| DK (1) | DK393184A (de) |
| FR (1) | FR2551758B1 (de) |
| IL (1) | IL72679A (de) |
| ZA (1) | ZA846322B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0688911B2 (ja) * | 1985-06-06 | 1994-11-09 | 国立予防衛生研究所長 | インフルエンザワクチン及びその製造方法 |
| WO1990014837A1 (en) * | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5709879A (en) * | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| AU691797B2 (en) * | 1993-01-29 | 1998-05-28 | Vetrepharm, Inc. | Immunotherapeutic composition |
| IL121070A (en) * | 1995-10-12 | 2004-06-20 | Supergen Inc | LIPOSOME FORMULATIONS OF 5beta STEROIDS |
| DE19631189A1 (de) * | 1996-08-02 | 1998-02-05 | Max Delbrueck Centrum | Neuartige kationische Amphiphile für den liposomalen Gentransfer |
| US20010051599A1 (en) | 1997-05-02 | 2001-12-13 | Michael Z. Kagan | Pregnan-3-ol-20-ones |
| AU2136501A (en) * | 1999-12-10 | 2001-06-18 | Celator Technologies Inc. | Lipid carrier compositions with protected surface reactive functions |
| FR3119325B1 (fr) * | 2021-01-29 | 2023-08-11 | Renault Jean Yves | Compositions liposomales orales |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2442241A2 (fr) * | 1978-03-20 | 1980-06-20 | Anvar | Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes |
| US4469797A (en) * | 1982-09-23 | 1984-09-04 | Miles Laboratories, Inc. | Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives |
-
1983
- 1983-08-16 FR FR8313333A patent/FR2551758B1/fr not_active Expired
-
1984
- 1984-08-14 IL IL72679A patent/IL72679A/xx unknown
- 1984-08-15 JP JP59170316A patent/JPS60126297A/ja active Pending
- 1984-08-15 ZA ZA846322A patent/ZA846322B/xx unknown
- 1984-08-16 EP EP84401681A patent/EP0139554B1/de not_active Expired
- 1984-08-16 DE DE8484401681T patent/DE3479215D1/de not_active Expired
- 1984-08-16 US US06/641,457 patent/US4663311A/en not_active Expired - Fee Related
- 1984-08-16 CA CA000461193A patent/CA1257584A/en not_active Expired
- 1984-08-16 AT AT84401681T patent/ATE45167T1/de not_active IP Right Cessation
- 1984-08-16 DK DK393184A patent/DK393184A/da not_active Application Discontinuation
- 1984-08-16 AU AU32003/84A patent/AU588219B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| IL72679A (en) | 1988-06-30 |
| ZA846322B (en) | 1985-03-27 |
| DE3479215D1 (en) | 1989-09-07 |
| CA1257584A (en) | 1989-07-18 |
| JPS60126297A (ja) | 1985-07-05 |
| FR2551758A1 (fr) | 1985-03-15 |
| FR2551758B1 (fr) | 1986-01-31 |
| AU3200384A (en) | 1985-02-21 |
| EP0139554A1 (de) | 1985-05-02 |
| AU588219B2 (en) | 1989-09-14 |
| US4663311A (en) | 1987-05-05 |
| EP0139554B1 (de) | 1989-08-02 |
| DK393184A (da) | 1985-02-17 |
| IL72679A0 (en) | 1984-11-30 |
| DK393184D0 (da) | 1984-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |