ATE448212T1 - Verfahren zur gewinnung von valinderivaten für die herstellung einer pharmazeutisch aktiven verbindung - Google Patents
Verfahren zur gewinnung von valinderivaten für die herstellung einer pharmazeutisch aktiven verbindungInfo
- Publication number
- ATE448212T1 ATE448212T1 AT06819100T AT06819100T ATE448212T1 AT E448212 T1 ATE448212 T1 AT E448212T1 AT 06819100 T AT06819100 T AT 06819100T AT 06819100 T AT06819100 T AT 06819100T AT E448212 T1 ATE448212 T1 AT E448212T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- obtaining
- give
- valin
- derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical class CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 title 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 3
- 150000007530 organic bases Chemical class 0.000 abstract 2
- 239000004072 C09CA03 - Valsartan Substances 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 230000006181 N-acylation Effects 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 208000037849 arterial hypertension Diseases 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000007866 imination reaction Methods 0.000 abstract 1
- 125000000879 imine group Chemical group 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000005580 one pot reaction Methods 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- XGISHOFUAFNYQF-UHFFFAOYSA-N pentanoyl chloride Chemical compound CCCCC(Cl)=O XGISHOFUAFNYQF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 229960004295 valine Drugs 0.000 abstract 1
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 abstract 1
- 229960004699 valsartan Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200502558A ES2288376B1 (es) | 2005-10-20 | 2005-10-20 | Procedimiento para la obtencion de intermedios utiles en la obtencion de un compuesto farmaceuticamente activo. |
| PCT/EP2006/067569 WO2007045675A1 (en) | 2005-10-20 | 2006-10-19 | Process for obtaining valine derivatives useful for obtaining a pharmaceutically active compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE448212T1 true ATE448212T1 (de) | 2009-11-15 |
Family
ID=37603219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06819100T ATE448212T1 (de) | 2005-10-20 | 2006-10-19 | Verfahren zur gewinnung von valinderivaten für die herstellung einer pharmazeutisch aktiven verbindung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7964749B2 (de) |
| EP (1) | EP1937654B1 (de) |
| JP (1) | JP2009512661A (de) |
| CN (1) | CN101309910A (de) |
| AT (1) | ATE448212T1 (de) |
| DE (1) | DE602006010423D1 (de) |
| ES (1) | ES2288376B1 (de) |
| WO (1) | WO2007045675A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2260018A2 (de) | 2008-04-07 | 2010-12-15 | Hetero Research Foundation | Verfahren zur herstellung eines valsartan-zwischenprodukts |
| CN107987125A (zh) * | 2017-11-23 | 2018-05-04 | 爱斯特（成都）生物制药股份有限公司 | 一种缬氨酸衍生物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0222056D0 (en) * | 2002-09-23 | 2002-10-30 | Novartis Ag | Process for the manufacture of organic compounds |
| ITMI20032267A1 (it) * | 2003-11-21 | 2005-05-22 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Procdimento per la preparzione di valsartan e suoi intermedi |
| ES2251292B1 (es) * | 2004-04-20 | 2007-07-01 | Inke, S.A. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de sus intermedios de sintesis. |
| EP1838681A2 (de) * | 2004-12-22 | 2007-10-03 | Enantia, S.L. | Zwischenprodukte für die herstellung eines angiotensin-ii-rezeptors und verfahren zur herstellung von valsartan |
-
2005
- 2005-10-20 ES ES200502558A patent/ES2288376B1/es not_active Expired - Fee Related
-
2006
- 2006-10-19 AT AT06819100T patent/ATE448212T1/de not_active IP Right Cessation
- 2006-10-19 CN CNA2006800423423A patent/CN101309910A/zh active Pending
- 2006-10-19 US US12/090,729 patent/US7964749B2/en not_active Expired - Fee Related
- 2006-10-19 WO PCT/EP2006/067569 patent/WO2007045675A1/en active Application Filing
- 2006-10-19 DE DE602006010423T patent/DE602006010423D1/de active Active
- 2006-10-19 JP JP2008536054A patent/JP2009512661A/ja not_active Withdrawn
- 2006-10-19 EP EP06819100A patent/EP1937654B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2288376B1 (es) | 2008-11-01 |
| EP1937654A1 (de) | 2008-07-02 |
| JP2009512661A (ja) | 2009-03-26 |
| US20100240919A1 (en) | 2010-09-23 |
| EP1937654B1 (de) | 2009-11-11 |
| DE602006010423D1 (de) | 2009-12-24 |
| ES2288376A1 (es) | 2008-01-01 |
| CN101309910A (zh) | 2008-11-19 |
| WO2007045675A1 (en) | 2007-04-26 |
| US7964749B2 (en) | 2011-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |