ATE447625T1 - Zusammensetzungen und verfahren zur verwendung von fmoc-derivaten bei der dna-/rna-synthese - Google Patents

Zusammensetzungen und verfahren zur verwendung von fmoc-derivaten bei der dna-/rna-synthese

Info

Publication number
ATE447625T1
ATE447625T1 AT03754749T AT03754749T ATE447625T1 AT E447625 T1 ATE447625 T1 AT E447625T1 AT 03754749 T AT03754749 T AT 03754749T AT 03754749 T AT03754749 T AT 03754749T AT E447625 T1 ATE447625 T1 AT E447625T1
Authority
AT
Austria
Prior art keywords
methods
fmoc
dna
compositions
fmoc derivatives
Prior art date
Application number
AT03754749T
Other languages
English (en)
Inventor
Gabriel Alvarado
Original Assignee
Syngen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngen Inc filed Critical Syngen Inc
Application granted granted Critical
Publication of ATE447625T1 publication Critical patent/ATE447625T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03754749T 2002-09-27 2003-09-25 Zusammensetzungen und verfahren zur verwendung von fmoc-derivaten bei der dna-/rna-synthese ATE447625T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41406102P 2002-09-27 2002-09-27
US10/670,015 US7534872B2 (en) 2002-09-27 2003-09-24 Compositions and methods for the use of FMOC derivatives in DNA/RNA synthesis
PCT/US2003/029465 WO2004029297A1 (en) 2002-09-27 2003-09-25 Compositions and methods for the use of fmoc derivatives in dna/ rna synthesis

Publications (1)

Publication Number Publication Date
ATE447625T1 true ATE447625T1 (de) 2009-11-15

Family

ID=32045270

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03754749T ATE447625T1 (de) 2002-09-27 2003-09-25 Zusammensetzungen und verfahren zur verwendung von fmoc-derivaten bei der dna-/rna-synthese

Country Status (7)

Country Link
US (3) US7534872B2 (de)
EP (1) EP1546390B1 (de)
AT (1) ATE447625T1 (de)
AU (1) AU2003272561B2 (de)
CA (1) CA2500285A1 (de)
DE (1) DE60329925D1 (de)
WO (1) WO2004029297A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5276118B2 (ja) * 2008-01-22 2013-08-28 カーディアック ペースメイカーズ， インコーポレイテッド 患者の状態を評価するシステム
US8981076B2 (en) * 2008-11-29 2015-03-17 Chemgenes Corporation Synthesis of N-FMOC protected deoxy nucleosides, ribo nucleosides, modified deoxy and ribo nucleosides, and phosphoramidites, and their use in oligonucleotide synthesis
EP2600901B1 (de) 2010-08-06 2019-03-27 ModernaTX, Inc. Pharmazeutische zusammensetzungen enthaltenbearbeitete nukleinsäuren und ihre medizinische verwendung
DE19177059T1 (de) 2010-10-01 2021-10-07 Modernatx, Inc. N1-methyl-pseudouracile enthältendes ribonucleinsäuren sowie ihre verwendungen
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
LT3682905T (lt) 2011-10-03 2022-02-25 Modernatx, Inc. Modifikuoti nukleozidai, nukleotidai ir nukleorūgštys bei jų naudojimas
PL2791160T3 (pl) 2011-12-16 2022-06-20 Modernatx, Inc. Kompozycje zmodyfikowanego mrna
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
RS63237B1 (sr) 2012-11-26 2022-06-30 Modernatx Inc Terminalno modifikovana rnk
US9481905B2 (en) * 2013-02-19 2016-11-01 Orizhan Bioscience Limited Method of using neutrilized DNA (N-DNA) as surface probe for high throughput detection platform
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
CA2923029A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Chimeric polynucleotides
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
WO2016011226A1 (en) 2014-07-16 2016-01-21 Moderna Therapeutics, Inc. Chimeric polynucleotides

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118800A (en) * 1983-12-20 1992-06-02 California Institute Of Technology Oligonucleotides possessing a primary amino group in the terminal nucleotide
US5015733A (en) 1983-12-20 1991-05-14 California Institute Of Technology Nucleosides possessing blocked aliphatic amino groups
US4849513A (en) 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US6469158B1 (en) 1992-05-14 2002-10-22 Ribozyme Pharmaceuticals, Incorporated Synthesis, deprotection, analysis and purification of RNA and ribozymes
DE60024906T2 (de) * 1999-03-05 2006-09-14 Tosoh Corp., Shinnanyo Eine am 3'-Ende modifizierte Nukleinsäuresonde, geeignet zur Hybridisierung und Detektion über Fluoreszenz
US6593466B1 (en) 1999-07-07 2003-07-15 Isis Pharmaceuticals, Inc. Guanidinium functionalized nucleotides and precursors thereof
US6958053B1 (en) * 1999-11-24 2005-10-25 Medrad, Inc. Injector providing drive member advancement and engagement with syringe plunger, and method of connecting a syringe to an injector
EP1237596B1 (de) * 1999-12-07 2004-06-16 Medrad, Inc. Spritzen, spritzenschläuche und flüssigkeitsübertragungssysteme
US6652489B2 (en) * 2000-02-07 2003-11-25 Medrad, Inc. Front-loading medical injector and syringes, syringe interfaces, syringe adapters and syringe plungers for use therewith
AUPQ867900A0 (en) * 2000-07-10 2000-08-03 Medrad, Inc. Medical injector system
US7018363B2 (en) * 2001-01-18 2006-03-28 Medrad, Inc. Encoding and sensing of syringe information
US7553294B2 (en) * 2002-05-30 2009-06-30 Medrad, Inc. Syringe plunger sensing mechanism for a medical injector
US7666169B2 (en) * 2003-11-25 2010-02-23 Medrad, Inc. Syringe and syringe plungers for use with medical injectors

Also Published As

Publication number Publication date
DE60329925D1 (de) 2009-12-17
AU2003272561A1 (en) 2004-04-19
EP1546390A4 (de) 2006-04-19
US7534872B2 (en) 2009-05-19
US20070179289A1 (en) 2007-08-02
WO2004029297A1 (en) 2004-04-08
US20040180355A1 (en) 2004-09-16
EP1546390A1 (de) 2005-06-29
CA2500285A1 (en) 2004-04-08
EP1546390B1 (de) 2009-11-04
US20090171076A1 (en) 2009-07-02
AU2003272561B2 (en) 2008-04-10
US7667033B2 (en) 2010-02-23

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