ATE442357T1 - Verfahren zur aufreinigung von ropinirolhydrochlorid - Google Patents
Verfahren zur aufreinigung von ropinirolhydrochloridInfo
- Publication number
- ATE442357T1 ATE442357T1 AT07736577T AT07736577T ATE442357T1 AT E442357 T1 ATE442357 T1 AT E442357T1 AT 07736577 T AT07736577 T AT 07736577T AT 07736577 T AT07736577 T AT 07736577T AT E442357 T1 ATE442357 T1 AT E442357T1
- Authority
- AT
- Austria
- Prior art keywords
- ropinirole hydrochloride
- purification
- treating
- iii
- free base
- Prior art date
Links
- XDXHAEQXIBQUEZ-UHFFFAOYSA-N Ropinirole hydrochloride Chemical compound Cl.CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 XDXHAEQXIBQUEZ-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title abstract 2
- UHSKFQJFRQCDBE-UHFFFAOYSA-N Ropinirole hydrochloride Natural products CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 abstract 4
- 229960002349 ropinirole hydrochloride Drugs 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000003610 charcoal Substances 0.000 abstract 1
- CSMWJXBSXGUPGY-UHFFFAOYSA-L sodium dithionate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)S([O-])(=O)=O CSMWJXBSXGUPGY-UHFFFAOYSA-L 0.000 abstract 1
- 229940075931 sodium dithionate Drugs 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN475MU2006 | 2006-03-29 | ||
| PCT/IN2007/000117 WO2007110880A2 (en) | 2006-03-29 | 2007-03-21 | A process for the purification of ropinirole hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442357T1 true ATE442357T1 (de) | 2009-09-15 |
Family
ID=38476954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07736577T ATE442357T1 (de) | 2006-03-29 | 2007-03-21 | Verfahren zur aufreinigung von ropinirolhydrochlorid |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7863462B2 (de) |
| EP (1) | EP2016050B1 (de) |
| AT (1) | ATE442357T1 (de) |
| BR (1) | BRPI0709185A2 (de) |
| CA (1) | CA2647790A1 (de) |
| DE (1) | DE602007002401D1 (de) |
| ES (1) | ES2332953T3 (de) |
| PL (1) | PL2016050T3 (de) |
| WO (1) | WO2007110880A2 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2645599A1 (en) * | 2006-03-29 | 2007-10-04 | Alembic Limited | A process for the purification of ropinirole hydrochloride |
| CN103086946B (zh) * | 2013-01-17 | 2018-10-23 | 浙江华海药业股份有限公司 | 一种盐酸罗匹尼罗纯化的方法 |
| MX2022009343A (es) * | 2020-02-03 | 2022-10-18 | Orion Corp | Composiciones farmaceuticas estables de ropinirol. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005105741A1 (en) | 2004-02-11 | 2005-11-10 | Sun Pharmaceutical Industries Limited | Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride |
| WO2005080333A1 (en) | 2004-02-19 | 2005-09-01 | Torrent Pharmaceuticals Ltd | Process for purification of ropinirole |
-
2007
- 2007-03-21 ES ES07736577T patent/ES2332953T3/es active Active
- 2007-03-21 US US12/294,994 patent/US7863462B2/en not_active Expired - Fee Related
- 2007-03-21 DE DE602007002401T patent/DE602007002401D1/de active Active
- 2007-03-21 PL PL07736577T patent/PL2016050T3/pl unknown
- 2007-03-21 AT AT07736577T patent/ATE442357T1/de not_active IP Right Cessation
- 2007-03-21 CA CA002647790A patent/CA2647790A1/en not_active Abandoned
- 2007-03-21 EP EP07736577A patent/EP2016050B1/de active Active
- 2007-03-21 BR BRPI0709185-0A patent/BRPI0709185A2/pt not_active Application Discontinuation
- 2007-03-21 WO PCT/IN2007/000117 patent/WO2007110880A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007110880A2 (en) | 2007-10-04 |
| EP2016050B1 (de) | 2009-09-09 |
| EP2016050A2 (de) | 2009-01-21 |
| PL2016050T3 (pl) | 2010-02-26 |
| ES2332953T3 (es) | 2010-02-15 |
| CA2647790A1 (en) | 2007-10-04 |
| US7863462B2 (en) | 2011-01-04 |
| US20100179332A1 (en) | 2010-07-15 |
| BRPI0709185A2 (pt) | 2011-06-28 |
| WO2007110880A3 (en) | 2007-11-29 |
| DE602007002401D1 (de) | 2009-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |