ATE440855T1 - In geschmacksrezeptorzellen exprimerter transient-rezeptor-potential-kanal trp8 - Google Patents
In geschmacksrezeptorzellen exprimerter transient-rezeptor-potential-kanal trp8Info
- Publication number
- ATE440855T1 ATE440855T1 AT01928618T AT01928618T ATE440855T1 AT E440855 T1 ATE440855 T1 AT E440855T1 AT 01928618 T AT01928618 T AT 01928618T AT 01928618 T AT01928618 T AT 01928618T AT E440855 T1 ATE440855 T1 AT E440855T1
- Authority
- AT
- Austria
- Prior art keywords
- trp8
- taste
- modulators
- potential channel
- exprimered
- Prior art date
Links
- 108010037150 Transient Receptor Potential Channels Proteins 0.000 title abstract 2
- 102000011753 Transient Receptor Potential Channels Human genes 0.000 title abstract 2
- 108091005708 gustatory receptors Proteins 0.000 title abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 235000019658 bitter taste Nutrition 0.000 abstract 2
- 230000008447 perception Effects 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 239000004097 EU approved flavor enhancer Substances 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 235000013361 beverage Nutrition 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 235000019264 food flavour enhancer Nutrition 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 210000003370 receptor cell Anatomy 0.000 abstract 1
- 235000019605 sweet taste sensations Nutrition 0.000 abstract 1
- 230000036327 taste response Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19749100P | 2000-04-17 | 2000-04-17 | |
| US09/834,792 US7364867B2 (en) | 2000-04-17 | 2001-04-13 | Method of identifying bitter compounds by employing TRP8, a transient receptor potential channel expressed in taste receptor cells |
| PCT/US2001/012608 WO2001079448A2 (en) | 2000-04-17 | 2001-04-17 | Trp8, a transient receptor potential channel expressed in taste receptor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE440855T1 true ATE440855T1 (de) | 2009-09-15 |
Family
ID=26892899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01928618T ATE440855T1 (de) | 2000-04-17 | 2001-04-17 | In geschmacksrezeptorzellen exprimerter transient-rezeptor-potential-kanal trp8 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US7364867B2 (de) |
| EP (1) | EP1282636B1 (de) |
| JP (1) | JP2004507220A (de) |
| AT (1) | ATE440855T1 (de) |
| AU (1) | AU2001255455A1 (de) |
| CA (1) | CA2406481A1 (de) |
| DE (1) | DE60139681D1 (de) |
| DK (1) | DK1282636T3 (de) |
| ES (1) | ES2331509T3 (de) |
| WO (1) | WO2001079448A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7364867B2 (en) | 2000-04-17 | 2008-04-29 | The Mount Sinai School Of Medicine | Method of identifying bitter compounds by employing TRP8, a transient receptor potential channel expressed in taste receptor cells |
| US20020164645A1 (en) * | 2000-12-29 | 2002-11-07 | The Regents Of The University Of California | Assays for taste receptor cell specific ion channel |
| US7723075B2 (en) | 2003-02-21 | 2010-05-25 | The Queens's Medical Center | Methods of screening for TRPM5 modulators |
| US7601883B2 (en) * | 2005-07-06 | 2009-10-13 | The Regents Of The University Of California | Mammalian sour/acid taste and CSF receptor genes, polypeptides and assays |
| US7407769B2 (en) | 2005-07-06 | 2008-08-05 | The Regents Of The University Of California | Method of identifying activity modulators of a polycystin-2L1 taste receptor polypeptide |
| WO2008008224A2 (en) * | 2006-07-10 | 2008-01-17 | Duke University | Sour taste receptor compositions and methods |
| JP2013533310A (ja) | 2010-08-09 | 2013-08-22 | ユニバーシティー オブ メリーランド，ボルティモア | 苦味物質を使用して閉塞性肺疾患を処置する方法 |
| US9128079B2 (en) | 2011-08-08 | 2015-09-08 | The Coca-Cola Company | Methods of using lung or bronchial epithelial cells to identify bitter taste modulators |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4826824A (en) | 1985-10-25 | 1989-05-02 | Duke University | Method of enhancing the taste perception of sweetness of aspartame and derivatives thereof |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5693756A (en) | 1994-02-28 | 1997-12-02 | The Johns Hopkins University | Amiloride-sensitive sodium channel and method of identifying substances which stimulate or block salty taste perception |
| CA2228456A1 (en) | 1995-07-31 | 1997-02-13 | Bush Boake Allen Inc. | Taste masking of thymol |
| US6860971B2 (en) | 1998-06-15 | 2005-03-01 | Gregory J. Ward | Process for recovery of olefinically unsaturated nitriles |
| US7402400B2 (en) * | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
| EP1100893A1 (de) | 1998-07-28 | 2001-05-23 | The Regents of the University of California | Nukleinsäuren, welche für proteine kodieren, die an der empfindungstransduktion beteiligt sind |
| DE19860833C1 (de) | 1998-12-30 | 2000-09-07 | Albrecht E Sippel | Methode zur zellulären High-Throughput(Hochdurchsatz)-Detektion von Rezeptor-Liganden-Interaktionen |
| WO2000044929A2 (en) | 1999-01-27 | 2000-08-03 | The Regents Of The University Of California | Assays for sensory modulators using a sensory cell specific g-protein alpha subunit |
| AU2976000A (en) | 1999-01-27 | 2000-08-18 | Regents Of The University Of California, The | Assays for sensory modulators using a sensory cell specific g-pr otein beta subunit |
| US6558910B2 (en) | 1999-09-10 | 2003-05-06 | The Regents Of The University Of California | SF, a novel family of taste receptors |
| DE19953167A1 (de) | 1999-11-04 | 2001-07-26 | Univ Mainz Johannes Gutenberg | Mit TRP-Proteinen verwandtes Protein MTR1 und dieses codierende DNA-Sequenz |
| US6608176B2 (en) | 2000-03-31 | 2003-08-19 | University Of Miami | Taste receptor for umami (monosodium glutamate) taste |
| US7364867B2 (en) * | 2000-04-17 | 2008-04-29 | The Mount Sinai School Of Medicine | Method of identifying bitter compounds by employing TRP8, a transient receptor potential channel expressed in taste receptor cells |
| AU2001270121A1 (en) | 2000-06-22 | 2002-01-02 | Senomyx, Inc. | Receptor fingerprinting, sensory perception, and biosensors of chemical sensants |
| ATE396266T1 (de) | 2000-07-28 | 2008-06-15 | Ulrich Wissenbach | Trp8 krebsmarker |
| US20030216545A1 (en) | 2000-09-28 | 2003-11-20 | Spytek Kimberly A. | Novel proteins and nucleic acids encoding same |
| GB0025572D0 (en) | 2000-10-18 | 2000-12-06 | Glaxo Group Ltd | New polypeptide |
| WO2002036622A2 (en) | 2000-10-30 | 2002-05-10 | Senomyx, Inc. | GαqPROETIN VARIANTS AND THEIR USE IN THE ANALYSIS AND DISCOVERY OF AGONISTS AND ANTAGONISTS OF CHEMOSENSORY RECEPTORS |
| US7041457B2 (en) * | 2000-10-30 | 2006-05-09 | Senomyx, Inc. | Gαq protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors |
| US20020164645A1 (en) * | 2000-12-29 | 2002-11-07 | The Regents Of The University Of California | Assays for taste receptor cell specific ion channel |
| WO2002068593A2 (en) | 2001-02-23 | 2002-09-06 | The Trustees Of Columbia University In The City Of New York | Chemosensory gene family encoding gustatory and olfactory receptors and uses thereof |
| WO2002087306A2 (en) | 2001-05-01 | 2002-11-07 | Senomyx, Inc. | High throughput cell-based assay for monitoring sodium channel activity and discovery of salty taste modulating compounds |
| US6942874B2 (en) * | 2001-05-25 | 2005-09-13 | Linguagen Corp. | Nucleotide compounds that block the bitter taste of oral compositions |
| US7115414B2 (en) | 2001-06-13 | 2006-10-03 | IRM LLC, A Delaware Corp. | Vanilloid receptor-related nucleic acids and polypeptides |
| WO2003004992A2 (en) | 2001-07-03 | 2003-01-16 | The Regents Of The University Of California | Mammalian sweet and amino acid heterodimeric taste receptors |
| AU2002336571A1 (en) | 2001-09-18 | 2003-04-01 | Irm, Llc | Sweet taste receptors |
| US7371841B2 (en) * | 2002-01-25 | 2008-05-13 | Regents Of The University Of California | Methods of modulating cold sensory perception |
| CA2486423A1 (en) | 2002-05-20 | 2003-12-11 | Tvd Taste Virtual Dimensions, Inc. | Antibodies and their use for the modulation of taste sensation |
| US7723075B2 (en) | 2003-02-21 | 2010-05-25 | The Queens's Medical Center | Methods of screening for TRPM5 modulators |
| DK1599732T3 (da) | 2003-03-05 | 2007-07-16 | Metabolex Inc | Fremgangsmåde og præparater til behandling af diagnosticering af diabetes og dermed beslægtede sygdomme som involverer beta-TRP |
-
2001
- 2001-04-13 US US09/834,792 patent/US7364867B2/en not_active Expired - Fee Related
- 2001-04-17 AU AU2001255455A patent/AU2001255455A1/en not_active Abandoned
- 2001-04-17 AT AT01928618T patent/ATE440855T1/de active
- 2001-04-17 JP JP2001577432A patent/JP2004507220A/ja active Pending
- 2001-04-17 ES ES01928618T patent/ES2331509T3/es not_active Expired - Lifetime
- 2001-04-17 WO PCT/US2001/012608 patent/WO2001079448A2/en active Search and Examination
- 2001-04-17 DE DE60139681T patent/DE60139681D1/de not_active Expired - Lifetime
- 2001-04-17 EP EP01928618A patent/EP1282636B1/de not_active Expired - Lifetime
- 2001-04-17 CA CA002406481A patent/CA2406481A1/en not_active Abandoned
- 2001-04-17 DK DK01928618T patent/DK1282636T3/da active
-
2006
- 2006-04-17 US US11/405,097 patent/US7341842B2/en not_active Expired - Fee Related
-
2008
- 2008-02-25 US US12/036,860 patent/US7960127B2/en not_active Expired - Fee Related
- 2008-03-07 US US12/044,263 patent/US7960128B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20060292548A1 (en) | 2006-12-28 |
| CA2406481A1 (en) | 2001-10-25 |
| US7341842B2 (en) | 2008-03-11 |
| EP1282636B1 (de) | 2009-08-26 |
| US7364867B2 (en) | 2008-04-29 |
| DE60139681D1 (de) | 2009-10-08 |
| DK1282636T3 (da) | 2009-11-23 |
| US20020037515A1 (en) | 2002-03-28 |
| US7960127B2 (en) | 2011-06-14 |
| US20080166743A1 (en) | 2008-07-10 |
| US20080182266A1 (en) | 2008-07-31 |
| JP2004507220A (ja) | 2004-03-11 |
| EP1282636A4 (de) | 2004-06-16 |
| ES2331509T3 (es) | 2010-01-07 |
| US7960128B2 (en) | 2011-06-14 |
| WO2001079448A3 (en) | 2002-12-05 |
| EP1282636A2 (de) | 2003-02-12 |
| AU2001255455A1 (en) | 2001-10-30 |
| WO2001079448A2 (en) | 2001-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1282636 Country of ref document: EP |
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| EEFA | Change of the company name |