ATE438389T1 - MIXING SYSTEM FOR PROVIDING SOLUBILITY OF PHARMACEUTICAL ACTIVE INGREDIENTS IN POLYMER MATRICES - Google Patents
MIXING SYSTEM FOR PROVIDING SOLUBILITY OF PHARMACEUTICAL ACTIVE INGREDIENTS IN POLYMER MATRICESInfo
- Publication number
- ATE438389T1 ATE438389T1 AT03722347T AT03722347T ATE438389T1 AT E438389 T1 ATE438389 T1 AT E438389T1 AT 03722347 T AT03722347 T AT 03722347T AT 03722347 T AT03722347 T AT 03722347T AT E438389 T1 ATE438389 T1 AT E438389T1
- Authority
- AT
- Austria
- Prior art keywords
- matrix
- active ingredients
- polymer matrix
- mixing system
- pharmaceutical active
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention is directed to a hybridized polymer matrix, a method of making such, and products incorporating such a matrix. The hybridized polymer matrix comprises a solvent-free polymer matrix base, a hybridized matrix comprising one or more poly(1-vinyl-2-pyrrolidones) and dimethyl sulfoxide, and at least one active substance. The hybridized polymer matrix is useful in the preparation of transdermal therapeutic systems, particularly making possible the introduction of pharmaceutically active substances which are otherwise difficult to dissolve, such as ibuprofen, into a non-polar matrix.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10212864A DE10212864B4 (en) | 2002-03-22 | 2002-03-22 | Polymer matrices comprising a mixing system for solubilization of pharmaceutical agents, processes for their preparation and their use |
PCT/EP2003/002953 WO2003080035A1 (en) | 2002-03-22 | 2003-03-21 | Hybrid system for solubilizing pharmaceutically active substances in polymer matrices |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE438389T1 true ATE438389T1 (en) | 2009-08-15 |
Family
ID=27815869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03722347T ATE438389T1 (en) | 2002-03-22 | 2003-03-21 | MIXING SYSTEM FOR PROVIDING SOLUBILITY OF PHARMACEUTICAL ACTIVE INGREDIENTS IN POLYMER MATRICES |
Country Status (7)
Country | Link |
---|---|
US (1) | US7256234B2 (en) |
EP (1) | EP1490038B1 (en) |
AT (1) | ATE438389T1 (en) |
AU (1) | AU2003229563A1 (en) |
DE (2) | DE10212864B4 (en) |
ES (1) | ES2328127T3 (en) |
WO (1) | WO2003080035A1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10360592A1 (en) * | 2003-12-19 | 2005-07-28 | Beiersdorf Ag | Plaster system for the administration of antihistamines |
DE102004038533A1 (en) | 2004-08-09 | 2006-02-23 | Beiersdorf Ag | Hydrous polymer matrix of hydrophobic polymers |
DE102004039728A1 (en) * | 2004-08-16 | 2006-02-23 | Beiersdorf Ag | Active substance-containing tape for the treatment of joint diseases |
JP5015562B2 (en) * | 2005-12-13 | 2012-08-29 | 日東電工株式会社 | Patch preparation |
DE102006017574A1 (en) * | 2006-04-13 | 2007-10-18 | Beiersdorf Ag | Use of combination of poly(1-vinyl-2-pyrrolidone) and/or its copolymer, and multivalent alcohols for the control of liquid absorption by polymer matrices and/or adhesive mass |
US20080226698A1 (en) * | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
DE102008022520A1 (en) * | 2008-05-07 | 2009-11-12 | Bayer Animal Health Gmbh | Solid sustained-release pharmaceutical formulation |
CA2739380C (en) * | 2008-10-06 | 2014-12-09 | Mylan Technologies, Inc. | Amorphous rotigotine transdermal system |
DE102008060904A1 (en) | 2008-12-09 | 2010-06-10 | Beiersdorf Ag | Water-soluble active ingredients in spray plaster |
EP2381961B1 (en) * | 2008-12-24 | 2016-09-14 | Janssen Sciences Ireland UC | Implantable devices for treating hiv |
US9303171B2 (en) | 2011-03-18 | 2016-04-05 | Tesla Nanocoatings, Inc. | Self-healing polymer compositions |
GB201120908D0 (en) * | 2011-12-06 | 2012-01-18 | Reckitt Benckiser Healthcare | Patch containing non-steroidal anti-inflammatory drug |
ITMI20121428A1 (en) * | 2012-08-10 | 2014-02-11 | Allergosystem S R L | DEVICE FOR THE TOPIC APPLICATION OF MEDICATIONS OR COSMETICS |
WO2014159798A1 (en) | 2013-03-13 | 2014-10-02 | Avery Dennison Corporation | Improving adhesive properties |
RU2560674C1 (en) * | 2014-02-21 | 2015-08-20 | Общество с ограниченной ответственностью "Инновации ветеринарии" (ООО "ИнВет") | All-purpose antibacterial agent |
EP3209388B1 (en) | 2014-10-21 | 2019-09-25 | The Procter and Gamble Company | Method of improving skin appearance |
EP3365066B1 (en) | 2015-10-22 | 2019-11-20 | The Procter and Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
WO2017070080A1 (en) | 2015-10-22 | 2017-04-27 | The Procter & Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
WO2018129495A1 (en) | 2017-01-09 | 2018-07-12 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
US10857076B2 (en) | 2017-01-09 | 2020-12-08 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
US10751265B2 (en) | 2017-01-09 | 2020-08-25 | The Procter & Gamble | Barrier patch with soluble film and methods of improving skin appearance |
CN110769945B (en) | 2017-06-22 | 2023-01-24 | 宝洁公司 | Cosmetic care film comprising a water-soluble layer and a vapor-deposited coating |
CN111698984B (en) | 2018-03-19 | 2023-11-14 | 宝洁公司 | Method for preparing barrier patch with soluble film |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6397272A (en) | 1986-10-15 | 1988-04-27 | Kiyoshi Ogawa | Formation of rust inhibitive film |
JPS6397202A (en) * | 1986-10-15 | 1988-04-27 | Toray Ind Inc | Polyether sulfone resin semipermeable membrane and its production |
DE3743946A1 (en) | 1987-09-01 | 1989-03-09 | Lohmann Gmbh & Co Kg | DEVICE FOR DELIVERING NITROGLYCERIN TO THE SKIN, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
US5273757A (en) | 1987-09-01 | 1993-12-28 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Apparatus for the delivery of substances, processes for the production thereof and use thereof |
US5306502A (en) | 1987-09-01 | 1994-04-26 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Apparatus for delivering nitroglycerin to the skin, processes for the production thereof and the use thereof |
DE3743947A1 (en) * | 1987-09-01 | 1989-03-09 | Lohmann Gmbh & Co Kg | DEVICE FOR THE CONTROLLED DELIVERY OF NICOTIN, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
SE8904296D0 (en) * | 1989-12-21 | 1989-12-21 | Pharmacia Ab | TRANSDERMAL SYSTEM |
DE4112508A1 (en) | 1991-04-17 | 1992-10-22 | Akzo Nv | SYNTHETIC HYDROPHILIC MEMBRANES AND METHOD FOR THE PRODUCTION THEREOF |
US6024975A (en) * | 1992-04-08 | 2000-02-15 | Americare International Diagnostics, Inc. | Method of transdermally administering high molecular weight drugs with a polymer skin enhancer |
AU6635294A (en) | 1993-04-22 | 1994-11-08 | Minnesota Mining And Manufacturing Company | Transdermal antiinflammatory composition |
US5906830A (en) | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
US5702720A (en) * | 1995-12-22 | 1997-12-30 | Minnesota Mining And Manufacturing Company | Transdermal device for the delivery of flurbiprofen |
DE19804604A1 (en) * | 1998-02-06 | 1999-08-12 | Beiersdorf Ag | Device for releasing substances |
DE19908787A1 (en) * | 1999-03-01 | 2000-09-14 | Labtec Gmbh | Transdermal therapeutic system for administration of fenoterol and formoterol, useful for treating obstructive respiratory disorders |
DE10012908B4 (en) | 2000-03-16 | 2005-03-17 | Lts Lohmann Therapie-Systeme Ag | Stabilized supersaturated transdermal therapeutic matrix systems and methods for their preparation |
-
2002
- 2002-03-22 DE DE10212864A patent/DE10212864B4/en not_active Expired - Fee Related
-
2003
- 2003-03-21 EP EP03722347A patent/EP1490038B1/en not_active Expired - Lifetime
- 2003-03-21 AU AU2003229563A patent/AU2003229563A1/en not_active Abandoned
- 2003-03-21 DE DE50311778T patent/DE50311778D1/en not_active Expired - Lifetime
- 2003-03-21 ES ES03722347T patent/ES2328127T3/en not_active Expired - Lifetime
- 2003-03-21 AT AT03722347T patent/ATE438389T1/en not_active IP Right Cessation
- 2003-03-21 WO PCT/EP2003/002953 patent/WO2003080035A1/en active Application Filing
-
2004
- 2004-09-22 US US10/948,763 patent/US7256234B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1490038B1 (en) | 2009-08-05 |
AU2003229563A1 (en) | 2003-10-08 |
WO2003080035A1 (en) | 2003-10-02 |
EP1490038A1 (en) | 2004-12-29 |
US7256234B2 (en) | 2007-08-14 |
DE50311778D1 (en) | 2009-09-17 |
DE10212864A1 (en) | 2003-10-09 |
DE10212864B4 (en) | 2005-12-22 |
ES2328127T3 (en) | 2009-11-10 |
US20050124743A1 (en) | 2005-06-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE438389T1 (en) | MIXING SYSTEM FOR PROVIDING SOLUBILITY OF PHARMACEUTICAL ACTIVE INGREDIENTS IN POLYMER MATRICES | |
MXPA05003591A (en) | Cyclodextrin-based materials, compositions and uses related thereto. | |
BR9908438A (en) | Rapid disintegration tablets | |
BG106455A (en) | Antibiotic, antibiotic polymer composition | |
WO2007128923A3 (en) | Method for the preparation of a biocompatible gel with controlled release of one or more active ingredients with low solubility in water, gels thus obtained and their use | |
WO2004039428A3 (en) | Transdermal delivery system for dried particulate or lyophilized medications | |
PT693924E (en) | PROCESSES FOR THE ADMINISTRATION (IN VIVO) OF BIOLOGICAL AND COMPOSITION SUBSTANCES USED IN THESE PROCESSES | |
DE69528057D1 (en) | Tocopherol compositions for the delivery of biologically active substances | |
ATE405251T1 (en) | COMPOSITIONS FOR DELAYED RELEASE OF HYDROPHOBIC MEDICINAL PRODUCTS AND METHOD FOR THE PRODUCTION THEREOF | |
DE69940735D1 (en) | BIODEGRADABLE ARRANGEMENTS FOR THE CONTROLLED RELEASE OF INCLUDED SUBSTANCES | |
ATE493114T1 (en) | MUCOADHESIVE COMPOSITION FOR ADMINISTRATION OF BIOLOGICALLY ACTIVE SUBSTANCES IN ANIMAL TISSUE | |
SE9704401D0 (en) | Matrix pellets for greasy, oily or sticky drug substances | |
Guggi et al. | Matrix tablets based on thiolated poly (acrylic acid): pH-dependent variation in disintegration and mucoadhesion | |
NO20052408D0 (en) | Pharmaceutical formulation of olanzapine | |
UY27929A1 (en) | PHARMACEUTICAL COMPOSITIONS OF SEMIORDENED AND POLYMER DRUGS | |
HUP0301177A2 (en) | Ion-strength independent sustained release pharmaceutical formulation | |
SE9603480L (en) | Dosage form for hard soluble drugs | |
EP1389468A4 (en) | Compositions for promoting healing of bone fracture | |
WO2004078111A3 (en) | Extended release minocycline compositions and processes for their preparation | |
WO2007076462A3 (en) | Sublimable sustained release delivery system and method of making same | |
AU2002336867A1 (en) | Micelle compositions containing pegylated phospholipids and a photosensitizer | |
UA83036C2 (en) | Pharmaceutical composition in the form of a hydrogel for transdermal administration of active substances | |
EA200601283A1 (en) | PHARMACEUTICAL COMPOSITION WITH CONTROLLED SURVIVAL, CONTAINING INSOLUBLE IN ACIDS POLYMER AND BIOADHESIVE POLYMER | |
CA2532714A1 (en) | Oral sustained-release tablet comprising 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide | |
DK1216028T3 (en) | Biodegradable support systems for therapeutically active substances and methods for their preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee |