ATE435293T1 - Invertierte terminale repeats von aav, die für die transkription aktiviert sind, zur verwendung in rekombinanten aav-vektoren - Google Patents
Invertierte terminale repeats von aav, die für die transkription aktiviert sind, zur verwendung in rekombinanten aav-vektorenInfo
- Publication number
- ATE435293T1 ATE435293T1 AT98953639T AT98953639T ATE435293T1 AT E435293 T1 ATE435293 T1 AT E435293T1 AT 98953639 T AT98953639 T AT 98953639T AT 98953639 T AT98953639 T AT 98953639T AT E435293 T1 ATE435293 T1 AT E435293T1
- Authority
- AT
- Austria
- Prior art keywords
- aav
- activated
- inverted terminal
- terminal repeats
- transcription
- Prior art date
Links
- 230000035897 transcription Effects 0.000 title 1
- 238000013518 transcription Methods 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
- 239000013607 AAV vector Substances 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Control Of El Displays (AREA)
- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95540097A | 1997-10-21 | 1997-10-21 | |
| PCT/US1998/021937 WO1999020773A2 (en) | 1997-10-21 | 1998-10-20 | TRANSCRIPTIONALLY-ACTIVATED AAV INVERTED TERMINAL REPEATS (ITRs) FOR USE WITH RECOMBINANT AAV VECTORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435293T1 true ATE435293T1 (de) | 2009-07-15 |
Family
ID=25496782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98953639T ATE435293T1 (de) | 1997-10-21 | 1998-10-20 | Invertierte terminale repeats von aav, die für die transkription aktiviert sind, zur verwendung in rekombinanten aav-vektoren |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1025243B1 (de) |
| JP (1) | JP2001520047A (de) |
| AT (1) | ATE435293T1 (de) |
| AU (1) | AU756827B2 (de) |
| CA (1) | CA2304801C (de) |
| DE (1) | DE69840948D1 (de) |
| WO (1) | WO1999020773A2 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6924128B2 (en) | 1994-12-06 | 2005-08-02 | Targeted Genetics Corporation | Packaging cell lines for generation of high titers of recombinant AAV vectors |
| US6995006B2 (en) | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6346415B1 (en) | 1997-10-21 | 2002-02-12 | Targeted Genetics Corporation | Transcriptionally-activated AAV inverted terminal repeats (ITRS) for use with recombinant AAV vectors |
| ATE495255T1 (de) | 1998-08-11 | 2011-01-15 | Darwin Discovery Ltd | Identifikation des gens das zum schorfigen phenotyp der maus führt, sowie seines menschlichen orthologs |
| US6893865B1 (en) | 1999-04-28 | 2005-05-17 | Targeted Genetics Corporation | Methods, compositions, and cells for encapsidating recombinant vectors in AAV particles |
| EP1939300A1 (de) | 1999-05-28 | 2008-07-02 | Targeted Genetics Corporation | Verfahren und Zusammensetzung zur Senkung des Spiegels des Tumornekrosefaktors (TNF) bei TNF-assoziierten Leiden |
| EP1180159B1 (de) | 1999-05-28 | 2008-09-03 | Targeted Genetics Corporation | Methoden und zusammensetzungen zur reduktion des tumor-nekrosis-faktor-spiegels (tnf) bei tnf-assoziierten erkrankungen |
| US6165754A (en) * | 1999-06-08 | 2000-12-26 | Cornell Research Foundation, Inc. | Method of expressing an exogenous nucleic acid |
| AU781958C (en) | 1999-08-09 | 2006-03-30 | Targeted Genetics Corporation | Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms intrastrand base pairs |
| WO2001027303A1 (en) * | 1999-10-12 | 2001-04-19 | The University Of North Carolina At Chapel Hill | Adeno-associated virus vectors encoding factor viii and methods of using the same |
| US7507542B2 (en) | 2001-05-08 | 2009-03-24 | Ucb Sa | Method for regulating immune function using the FOXP3 protein |
| SG10202109219SA (en) | 2009-05-02 | 2021-10-28 | Genzyme Corp | Gene therapy for neurodegenerative disorders |
| WO2017139381A1 (en) | 2016-02-08 | 2017-08-17 | University Of Iowa Research Foundation | Methods to produce chimeric adeno-associated virus/bocavirus parvovirus |
| CA3016985C (en) * | 2016-03-07 | 2023-07-04 | University Of Iowa Research Foundation | Aav-mediated expression using a synthetic promoter and enhancer |
| US12173305B2 (en) | 2016-05-26 | 2024-12-24 | University Of Iowa Research Foundation | cis and trans requirements for terminal resolution of human bocavirus 1 |
| US11142775B2 (en) | 2017-01-13 | 2021-10-12 | University Of Iowa Research Foundation | Bocaparvovirus small noncoding RNA and uses thereof |
| EP4087918A4 (de) * | 2020-01-07 | 2024-02-28 | The University of North Carolina at Chapel Hill | Synthetische adeno-assoziierte virusinvertierte terminal-repeats und verfahren zu ihrer verwendung als promoter |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5587308A (en) * | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| JPH09509564A (ja) * | 1993-11-09 | 1997-09-30 | ターゲテッド ジェネティックス コーポレイション | 高力価組換えａａｖベクターの生成 |
-
1998
- 1998-10-20 AT AT98953639T patent/ATE435293T1/de not_active IP Right Cessation
- 1998-10-20 JP JP2000517093A patent/JP2001520047A/ja active Pending
- 1998-10-20 DE DE69840948T patent/DE69840948D1/de not_active Expired - Lifetime
- 1998-10-20 EP EP98953639A patent/EP1025243B1/de not_active Expired - Lifetime
- 1998-10-20 CA CA002304801A patent/CA2304801C/en not_active Expired - Fee Related
- 1998-10-20 AU AU10966/99A patent/AU756827B2/en not_active Ceased
- 1998-10-20 WO PCT/US1998/021937 patent/WO1999020773A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1025243B1 (de) | 2009-07-01 |
| WO1999020773A2 (en) | 1999-04-29 |
| AU756827B2 (en) | 2003-01-23 |
| EP1025243A2 (de) | 2000-08-09 |
| WO1999020773A3 (en) | 1999-07-01 |
| JP2001520047A (ja) | 2001-10-30 |
| AU1096699A (en) | 1999-05-10 |
| DE69840948D1 (de) | 2009-08-13 |
| CA2304801A1 (en) | 1999-04-29 |
| CA2304801C (en) | 2009-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |