ATE429439T1 - Ligierungsverfahren - Google Patents
LigierungsverfahrenInfo
- Publication number
- ATE429439T1 ATE429439T1 AT04767986T AT04767986T ATE429439T1 AT E429439 T1 ATE429439 T1 AT E429439T1 AT 04767986 T AT04767986 T AT 04767986T AT 04767986 T AT04767986 T AT 04767986T AT E429439 T1 ATE429439 T1 AT E429439T1
- Authority
- AT
- Austria
- Prior art keywords
- moiety
- oligopeptide
- peptides
- providing
- activated ester
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000015636 Oligopeptides Human genes 0.000 abstract 7
- 108010038807 Oligopeptides Proteins 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- -1 amino-óxy moiety Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 230000017730 intein-mediated protein splicing Effects 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 239000003774 sulfhydryl reagent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Surgical Instruments (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0318276A GB0318276D0 (en) | 2003-08-05 | 2003-08-05 | Ligation method |
| GB0320122A GB0320122D0 (en) | 2003-08-28 | 2003-08-28 | Ligation method |
| PCT/GB2004/003391 WO2005014620A1 (en) | 2003-08-05 | 2004-08-05 | Ligation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429439T1 true ATE429439T1 (de) | 2009-05-15 |
Family
ID=34137749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04767986T ATE429439T1 (de) | 2003-08-05 | 2004-08-05 | Ligierungsverfahren |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7622552B2 (de) |
| EP (1) | EP1651664B9 (de) |
| JP (1) | JP4637838B2 (de) |
| AT (1) | ATE429439T1 (de) |
| AU (1) | AU2004263366A1 (de) |
| CA (1) | CA2534520C (de) |
| DE (1) | DE602004020776D1 (de) |
| DK (1) | DK1651664T3 (de) |
| ES (1) | ES2323706T3 (de) |
| PL (1) | PL1651664T3 (de) |
| PT (1) | PT1651664E (de) |
| WO (1) | WO2005014620A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2468881A3 (de) * | 2005-07-21 | 2012-08-15 | Abbott Laboratories | Mehrfache Genexpression mit sORF-Konstrukten und Verfahren mit Polyproteinen, Pro-Proteinen und Proteolyse |
| EP1770099A1 (de) * | 2005-09-28 | 2007-04-04 | University of Geneva | Verfahren zur Herstellung von modifizierten Polypeptiden |
| EP2350112A4 (de) * | 2008-10-03 | 2013-01-16 | Advanced Proteome Therapeutics Inc | Ortsspezifische n-terminus-proteinmodifikationen und konjugatbildung |
| GB0908393D0 (en) * | 2009-05-15 | 2009-06-24 | Almac Sciences Scotland Ltd | Labelling method |
| WO2011053699A1 (en) * | 2009-10-30 | 2011-05-05 | Abbott Laboratories | Sorf constructs and multiple gene expression |
| US9557336B2 (en) | 2012-09-07 | 2017-01-31 | University Of Rochester | Methods and compositions for site-specific labeling of peptides and proteins |
| WO2015068532A1 (ja) * | 2013-11-05 | 2015-05-14 | 味の素株式会社 | ペプチドヒドラジド、ペプチドアミド及びペプチドチオエステルの製造方法 |
| US9593142B2 (en) | 2013-12-26 | 2017-03-14 | New York University | Aldehyde capture ligation technology for synthesis of amide bonds |
| GB201721802D0 (en) | 2017-12-22 | 2018-02-07 | Almac Discovery Ltd | Ror1-specific antigen binding molecules |
| GB202020154D0 (en) | 2020-12-18 | 2021-02-03 | Almac Discovery Ltd | ROR1-specific variant antigen binding molecules |
| CN115043899B (zh) * | 2022-05-24 | 2024-10-22 | 南开大学 | 双胺或胺与硫醇偶联的化合物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3985617A (en) * | 1974-10-29 | 1976-10-12 | Ajinomoto Co., Inc. | Immobilization of biologically active proteins with a polypeptide azide |
| GB9702088D0 (en) * | 1997-01-31 | 1997-03-19 | Pharmacia & Upjohn Spa | Matrix metalloproteinase inhibitors |
| US5965714A (en) * | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
| EP1117693B1 (de) | 1998-09-30 | 2006-05-17 | New England Biolabs, Inc. | Intein vermittelte peptidligation |
| US6586398B1 (en) * | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| WO2001098458A2 (en) * | 2000-06-19 | 2001-12-27 | Zyomyx, Inc. | Methods for immobilizing polypeptides |
| US7176037B2 (en) * | 2000-07-13 | 2007-02-13 | The Scripps Research Institute | Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation |
-
2004
- 2004-08-05 ES ES04767986T patent/ES2323706T3/es not_active Expired - Lifetime
- 2004-08-05 US US10/567,403 patent/US7622552B2/en not_active Expired - Lifetime
- 2004-08-05 JP JP2006522408A patent/JP4637838B2/ja not_active Expired - Fee Related
- 2004-08-05 DE DE602004020776T patent/DE602004020776D1/de not_active Expired - Lifetime
- 2004-08-05 AU AU2004263366A patent/AU2004263366A1/en not_active Abandoned
- 2004-08-05 CA CA2534520A patent/CA2534520C/en not_active Expired - Fee Related
- 2004-08-05 DK DK04767986T patent/DK1651664T3/da active
- 2004-08-05 AT AT04767986T patent/ATE429439T1/de not_active IP Right Cessation
- 2004-08-05 PL PL04767986T patent/PL1651664T3/pl unknown
- 2004-08-05 WO PCT/GB2004/003391 patent/WO2005014620A1/en not_active Ceased
- 2004-08-05 PT PT04767986T patent/PT1651664E/pt unknown
- 2004-08-05 EP EP04767986A patent/EP1651664B9/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005014620A1 (en) | 2005-02-17 |
| CA2534520A1 (en) | 2005-02-17 |
| US7622552B2 (en) | 2009-11-24 |
| PL1651664T3 (pl) | 2009-09-30 |
| JP2007534626A (ja) | 2007-11-29 |
| DE602004020776D1 (de) | 2009-06-04 |
| EP1651664B1 (de) | 2009-04-22 |
| AU2004263366A1 (en) | 2005-02-17 |
| EP1651664A1 (de) | 2006-05-03 |
| ES2323706T3 (es) | 2009-07-23 |
| PT1651664E (pt) | 2009-09-02 |
| EP1651664B9 (de) | 2012-03-21 |
| US20060247417A1 (en) | 2006-11-02 |
| JP4637838B2 (ja) | 2011-02-23 |
| CA2534520C (en) | 2014-04-08 |
| DK1651664T3 (da) | 2009-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |