ATE429439T1 - Ligierungsverfahren - Google Patents
LigierungsverfahrenInfo
- Publication number
- ATE429439T1 ATE429439T1 AT04767986T AT04767986T ATE429439T1 AT E429439 T1 ATE429439 T1 AT E429439T1 AT 04767986 T AT04767986 T AT 04767986T AT 04767986 T AT04767986 T AT 04767986T AT E429439 T1 ATE429439 T1 AT E429439T1
- Authority
- AT
- Austria
- Prior art keywords
- moiety
- oligopeptide
- peptides
- providing
- activated ester
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000015636 Oligopeptides Human genes 0.000 abstract 7
- 108010038807 Oligopeptides Proteins 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- -1 amino-óxy moiety Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 230000017730 intein-mediated protein splicing Effects 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 239000003774 sulfhydryl reagent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Surgical Instruments (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0318276A GB0318276D0 (en) | 2003-08-05 | 2003-08-05 | Ligation method |
| GB0320122A GB0320122D0 (en) | 2003-08-28 | 2003-08-28 | Ligation method |
| PCT/GB2004/003391 WO2005014620A1 (en) | 2003-08-05 | 2004-08-05 | Ligation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429439T1 true ATE429439T1 (de) | 2009-05-15 |
Family
ID=34137749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04767986T ATE429439T1 (de) | 2003-08-05 | 2004-08-05 | Ligierungsverfahren |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7622552B2 (de) |
| EP (1) | EP1651664B9 (de) |
| JP (1) | JP4637838B2 (de) |
| AT (1) | ATE429439T1 (de) |
| AU (1) | AU2004263366A1 (de) |
| CA (1) | CA2534520C (de) |
| DE (1) | DE602004020776D1 (de) |
| DK (1) | DK1651664T3 (de) |
| ES (1) | ES2323706T3 (de) |
| PL (1) | PL1651664T3 (de) |
| PT (1) | PT1651664E (de) |
| WO (1) | WO2005014620A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2478709C2 (ru) * | 2005-07-21 | 2013-04-10 | Эбботт Лэборетриз | ЭКСПРЕССИЯ МНОЖЕСТВА ГЕНОВ, ВКЛЮЧАЯ sORF-КОНСТРУКЦИИ, И СПОСОБЫ ЭКСПРЕССИРОВАНИЯ ИММУНОГЛОБУЛИНА |
| EP1770099A1 (de) * | 2005-09-28 | 2007-04-04 | University of Geneva | Verfahren zur Herstellung von modifizierten Polypeptiden |
| EP2350112A4 (de) * | 2008-10-03 | 2013-01-16 | Advanced Proteome Therapeutics Inc | Ortsspezifische n-terminus-proteinmodifikationen und konjugatbildung |
| GB0908393D0 (en) * | 2009-05-15 | 2009-06-24 | Almac Sciences Scotland Ltd | Labelling method |
| CA2776990A1 (en) * | 2009-10-30 | 2011-05-05 | Abbott Laboratories | Sorf constructs and multiple gene expression |
| EP2892929A4 (de) | 2012-09-07 | 2016-04-13 | Univ Rochester | Verfahren und zusammensetzungen zur stellenspezifischen markierung von peptiden und proteinen |
| WO2015068532A1 (ja) * | 2013-11-05 | 2015-05-14 | 味の素株式会社 | ペプチドヒドラジド、ペプチドアミド及びペプチドチオエステルの製造方法 |
| US9593142B2 (en) | 2013-12-26 | 2017-03-14 | New York University | Aldehyde capture ligation technology for synthesis of amide bonds |
| GB201721802D0 (en) | 2017-12-22 | 2018-02-07 | Almac Discovery Ltd | Ror1-specific antigen binding molecules |
| GB202020154D0 (en) | 2020-12-18 | 2021-02-03 | Almac Discovery Ltd | ROR1-specific variant antigen binding molecules |
| CN115043899B (zh) * | 2022-05-24 | 2024-10-22 | 南开大学 | 双胺或胺与硫醇偶联的化合物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3985617A (en) * | 1974-10-29 | 1976-10-12 | Ajinomoto Co., Inc. | Immobilization of biologically active proteins with a polypeptide azide |
| GB9702088D0 (en) * | 1997-01-31 | 1997-03-19 | Pharmacia & Upjohn Spa | Matrix metalloproteinase inhibitors |
| US5965714A (en) * | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
| WO2000018881A2 (en) * | 1998-09-30 | 2000-04-06 | New England Biolabs, Inc. | Intein mediated peptide ligation |
| US6586398B1 (en) * | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| AU2001269906A1 (en) * | 2000-06-19 | 2002-01-02 | Zyomyx, Inc. | Methods for immobilizing polypeptides |
| US7176037B2 (en) * | 2000-07-13 | 2007-02-13 | The Scripps Research Institute | Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation |
-
2004
- 2004-08-05 PL PL04767986T patent/PL1651664T3/pl unknown
- 2004-08-05 DE DE602004020776T patent/DE602004020776D1/de not_active Expired - Lifetime
- 2004-08-05 EP EP04767986A patent/EP1651664B9/de not_active Expired - Lifetime
- 2004-08-05 DK DK04767986T patent/DK1651664T3/da active
- 2004-08-05 CA CA2534520A patent/CA2534520C/en not_active Expired - Fee Related
- 2004-08-05 AU AU2004263366A patent/AU2004263366A1/en not_active Abandoned
- 2004-08-05 WO PCT/GB2004/003391 patent/WO2005014620A1/en not_active Ceased
- 2004-08-05 AT AT04767986T patent/ATE429439T1/de not_active IP Right Cessation
- 2004-08-05 ES ES04767986T patent/ES2323706T3/es not_active Expired - Lifetime
- 2004-08-05 PT PT04767986T patent/PT1651664E/pt unknown
- 2004-08-05 JP JP2006522408A patent/JP4637838B2/ja not_active Expired - Fee Related
- 2004-08-05 US US10/567,403 patent/US7622552B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20060247417A1 (en) | 2006-11-02 |
| CA2534520A1 (en) | 2005-02-17 |
| EP1651664A1 (de) | 2006-05-03 |
| PL1651664T3 (pl) | 2009-09-30 |
| CA2534520C (en) | 2014-04-08 |
| AU2004263366A1 (en) | 2005-02-17 |
| JP2007534626A (ja) | 2007-11-29 |
| WO2005014620A1 (en) | 2005-02-17 |
| ES2323706T3 (es) | 2009-07-23 |
| DE602004020776D1 (de) | 2009-06-04 |
| EP1651664B1 (de) | 2009-04-22 |
| DK1651664T3 (da) | 2009-08-24 |
| US7622552B2 (en) | 2009-11-24 |
| EP1651664B9 (de) | 2012-03-21 |
| JP4637838B2 (ja) | 2011-02-23 |
| PT1651664E (pt) | 2009-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Pattabiraman et al. | Chemical protein synthesis by chemoselective α‐ketoacid–hydroxylamine (KAHA) ligations with 5‐oxaproline | |
| ATE429439T1 (de) | Ligierungsverfahren | |
| EP2484774A3 (de) | Mehrfache Genexpression mit sORF-Konstrukten und Verfahren mit Polyproteinen, Pro-Proteinen und Proteolyse | |
| Kramer et al. | Reversible chemoselective tagging and functionalization of methionine containing peptides | |
| Malins et al. | Oxidative deselenization of selenocysteine: applications for programmed ligation at serine | |
| Dawson et al. | Modulation of reactivity in native chemical ligation through the use of thiol additives | |
| El Oualid et al. | Chemical synthesis of ubiquitin, ubiquitin‐based probes, and diubiquitin | |
| Cousins et al. | Molecular evolution: dynamic combinatorial libraries, autocatalytic networks and the quest for molecular function | |
| Ramström et al. | Synthesis and catalysis by molecularly imprinted materials | |
| Shang et al. | An advance in proline ligation | |
| Meledin et al. | Protein ubiquitination via dehydroalanine: development and insights into the diastereoselective 1, 4-addition step | |
| AU1240201A (en) | Tag library compounds, compositions, kits and methods of use | |
| WO2005051976A3 (en) | Protein and peptide ligation processes and one-step purification processes | |
| DE60335000D1 (de) | In vitro peptid-expressionsbank | |
| ATE330224T1 (de) | Funktionelles protein array | |
| ATE537260T1 (de) | Terpen synthase/cyclase und olefin synthase sowie deren verwendung | |
| An et al. | Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis | |
| WO2003076949A3 (en) | Tagging and recovery of elements associated with target molecules | |
| Prusis et al. | Proteochemometrics analysis of substrate interactions with dengue virus NS3 proteases | |
| Niedermaier et al. | Positional proteomics for identification of secreted proteoforms released by site-specific processing of membrane proteins | |
| AU6153001A (en) | Ligation method and reagents to form an amide bond | |
| WO2004033718A3 (en) | Trap-tagging: a novel method for the identification and purification of rna-protein complexes | |
| Matveenko et al. | Utility of the phenacyl protecting group in traceless protein semisynthesis through ligation–Desulfurization chemistry | |
| Edwards et al. | Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases | |
| Rose et al. | Enzymatic incorporation of orthogonally reactive prenylazide groups into peptides using geranylazide diphosphate via protein farnesyltransferase: implications for selective protein labeling |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |