ATE427950T1 - Trioxanderivate zur verwendung als antimalaria- oder antikrebs-verbindungen - Google Patents

Trioxanderivate zur verwendung als antimalaria- oder antikrebs-verbindungen

Info

Publication number
ATE427950T1
ATE427950T1 AT02785623T AT02785623T ATE427950T1 AT E427950 T1 ATE427950 T1 AT E427950T1 AT 02785623 T AT02785623 T AT 02785623T AT 02785623 T AT02785623 T AT 02785623T AT E427950 T1 ATE427950 T1 AT E427950T1
Authority
AT
Austria
Prior art keywords
antimalaria
trioxan
derivatives
compounds
cancer compounds
Prior art date
Application number
AT02785623T
Other languages
English (en)
Inventor
Paul Michael O'neill
Adrian Peter Higson
Sara Taylor
Edward Irving
Original Assignee
Ufc Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0129214A external-priority patent/GB0129214D0/en
Priority claimed from GB0217724A external-priority patent/GB0217724D0/en
Application filed by Ufc Ltd filed Critical Ufc Ltd
Application granted granted Critical
Publication of ATE427950T1 publication Critical patent/ATE427950T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT02785623T 2001-12-06 2002-12-06 Trioxanderivate zur verwendung als antimalaria- oder antikrebs-verbindungen ATE427950T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0129214A GB0129214D0 (en) 2001-12-06 2001-12-06 Trioxane derivatives
GB0217724A GB0217724D0 (en) 2002-07-31 2002-07-31 Trioxane derivatives

Publications (1)

Publication Number Publication Date
ATE427950T1 true ATE427950T1 (de) 2009-04-15

Family

ID=26246841

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02785623T ATE427950T1 (de) 2001-12-06 2002-12-06 Trioxanderivate zur verwendung als antimalaria- oder antikrebs-verbindungen

Country Status (8)

Country Link
US (1) US20050070595A1 (de)
EP (1) EP1461340B1 (de)
JP (1) JP2005516909A (de)
AT (1) ATE427950T1 (de)
AU (1) AU2002350910A1 (de)
CA (1) CA2469223A1 (de)
DE (1) DE60231912D1 (de)
WO (1) WO2003048168A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060217291A1 (en) 2005-03-25 2006-09-28 Ichiro Hirotsu Radiosensitizer
KR20140126404A (ko) * 2005-10-20 2014-10-30 에피팜 게엠베하 아르테미시닌 및 그의 유도체를 이용한 양성 착색 점(반점)의 처치 및 예방
WO2008099415A1 (en) * 2007-02-13 2008-08-21 Council Of Scientific & Industrial Research Novel substituted bis-1, 2, 4-trioxanes and a process for preparation thereof
FR2925495B1 (fr) * 2007-12-21 2010-09-10 Pf Medicament Derives dimeriques d'artemisinine et application en therapie anticancereuse
CN103183682B (zh) * 2011-12-31 2015-10-14 沈阳药科大学 C-10位脲基取代的青蒿素衍生物及其制备方法和用途
CN106588950B (zh) * 2016-12-13 2018-05-08 昆药集团股份有限公司 青蒿琥酯衍生物、其制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677468A (en) * 1995-06-29 1997-10-14 Hauser, Inc. Artemisinin dimer compounds having anticancer activity
US6156790A (en) * 1997-12-30 2000-12-05 Hauser, Inc. C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities
US6160004A (en) * 1997-12-30 2000-12-12 Hauser, Inc. C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities
CN1084333C (zh) * 1998-06-17 2002-05-08 中国科学院上海药物研究所 新的青蒿素化合物,其制备方法以及含有它们的药物组合物
US6297272B1 (en) * 1999-01-12 2001-10-02 Hauser, Inc. Artemisinin analogs having antimalarial antiproliferative and antitumor activities and chemoselective methods of making the same
WO2001062299A2 (en) * 2000-02-28 2001-08-30 Shearwater Corporation Water-soluble polymer conjugates of artelinic acid

Also Published As

Publication number Publication date
WO2003048168A2 (en) 2003-06-12
WO2003048168A3 (en) 2003-07-24
CA2469223A1 (en) 2003-06-12
US20050070595A1 (en) 2005-03-31
EP1461340A2 (de) 2004-09-29
AU2002350910A1 (en) 2003-06-17
JP2005516909A (ja) 2005-06-09
DE60231912D1 (de) 2009-05-20
EP1461340B1 (de) 2009-04-08
AU2002350910A8 (en) 2003-06-17

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Legal Events

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