ATE423765T1 - Ep2-rezeptoragonisten - Google Patents
Ep2-rezeptoragonistenInfo
- Publication number
- ATE423765T1 ATE423765T1 AT04806216T AT04806216T ATE423765T1 AT E423765 T1 ATE423765 T1 AT E423765T1 AT 04806216 T AT04806216 T AT 04806216T AT 04806216 T AT04806216 T AT 04806216T AT E423765 T1 ATE423765 T1 AT E423765T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor agonists
- sub
- receptor
- agonism
- prodrug
- Prior art date
Links
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 230000008484 agonism Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0329620.9A GB0329620D0 (en) | 2003-12-22 | 2003-12-22 | EP2 receptor agonists |
US53197903P | 2003-12-24 | 2003-12-24 | |
US62201204P | 2004-10-27 | 2004-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE423765T1 true ATE423765T1 (de) | 2009-03-15 |
Family
ID=30776234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04806216T ATE423765T1 (de) | 2003-12-22 | 2004-12-22 | Ep2-rezeptoragonisten |
Country Status (8)
Country | Link |
---|---|
US (2) | US20080045596A1 (de) |
EP (1) | EP1716113B1 (de) |
JP (1) | JP2007515467A (de) |
AT (1) | ATE423765T1 (de) |
DE (1) | DE602004019697D1 (de) |
ES (1) | ES2322765T3 (de) |
GB (1) | GB0329620D0 (de) |
WO (1) | WO2005061449A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1723132A1 (de) * | 2004-02-12 | 2006-11-22 | Asterand Uk Limited | Agonisten des ep2-rezeptors |
US7091231B2 (en) | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
CA2618486A1 (en) | 2005-08-09 | 2007-02-15 | Asterand Uk Limited | Ep2 receptor agonists |
JP5410271B2 (ja) * | 2006-04-04 | 2014-02-05 | アラーガン インコーポレイテッド | 緑内障治療用プロスタグランジン化合物 |
US7491844B2 (en) | 2006-05-04 | 2009-02-17 | Allergan, Inc. | Therapeutic cyclopentane derivatives |
WO2008091818A1 (en) | 2007-01-25 | 2008-07-31 | Allergan, Inc. | Substituted arylcyclopentenes as therapeutic agents |
US9365485B2 (en) | 2007-01-25 | 2016-06-14 | Allergan, Inc. | Substituted arylcyclopentenes as therapeutic agents |
US7781465B2 (en) * | 2007-08-21 | 2010-08-24 | Allergan, Inc. | Therapeutic oxazolidinones and thiazolidinones |
MX2010008226A (es) * | 2008-02-05 | 2010-10-25 | Asterand Uk Ltd | Derivados de difluorobifenilamida para el tratamiento de hipertension ocular. |
DK2264009T3 (en) | 2008-03-12 | 2019-04-15 | Ube Industries | PYRIDYLAMINE ACEDIC ACID COMPOUND |
JP5836262B2 (ja) | 2009-03-19 | 2015-12-24 | フェイト セラピューティクス, インコーポレイテッド | サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法 |
SI2415763T1 (sl) | 2009-03-30 | 2016-05-31 | Ube Industries, Ltd. | Farmacevtski sestavek za zdravljenje ali preprečevanje glavkoma |
WO2011030872A1 (ja) * | 2009-09-11 | 2011-03-17 | 宇部興産株式会社 | スルホンアミド化合物 |
EP2476668B1 (de) * | 2009-09-11 | 2013-11-06 | Ube Industries, Ltd. | Anilinverbindungen |
WO2011030865A1 (ja) * | 2009-09-11 | 2011-03-17 | 宇部興産株式会社 | 置換ベンジル化合物 |
WO2011030873A1 (ja) * | 2009-09-11 | 2011-03-17 | 宇部興産株式会社 | ベンジル化合物 |
EP2888250B1 (de) | 2012-08-21 | 2017-07-19 | Allergan, Inc. | Verfahren zur synthese substituierter gamma-lactame |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4599353A (en) * | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
US5462968A (en) * | 1994-01-19 | 1995-10-31 | Allergan, Inc. | EP2 -receptor agonists as agents for lowering intraocular pressure |
US5576347A (en) * | 1994-11-14 | 1996-11-19 | Sredni; Benjamin | Method of treating gastric ulcers |
US5631287A (en) * | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
US6011062A (en) * | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
US5698598A (en) * | 1995-08-04 | 1997-12-16 | Allergan | EP2 -receptor agonists as agents for lowering intraocular pressure |
US5877211A (en) * | 1997-11-21 | 1999-03-02 | Allergan | EP2 receptor agonists as neuroprotective agents for the eye |
US6090847A (en) * | 1997-11-21 | 2000-07-18 | Allergan Sales, Inc. | EP2 -receptor agonists as neuroprotective agents for the eye |
US6235781B1 (en) * | 1998-07-14 | 2001-05-22 | Alcon Laboratories, Inc. | Prostaglandin product |
US6437146B1 (en) * | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
SE9900025D0 (sv) * | 1999-01-08 | 1999-01-08 | Synphora Ab | Method and composition for treatment of female sexual dysfunction |
DE60118628T2 (de) * | 2001-10-26 | 2007-02-15 | Allergan, Inc., Irvine | Omega-cycloalkyl 17-heteroaryl prostaglandin e2 analogen als ep2-rezeptor agonisten |
WO2003040126A1 (en) * | 2001-11-05 | 2003-05-15 | Allergan, Inc. | φ-CYCLOALKYL 17-HETEROARYL PROSTAGLANDIN E2 ANALOGS AS EP2-RECEPTOR AGONISTS |
-
2003
- 2003-12-22 GB GBGB0329620.9A patent/GB0329620D0/en not_active Ceased
-
2004
- 2004-12-22 WO PCT/GB2004/005421 patent/WO2005061449A1/en active Application Filing
- 2004-12-22 DE DE602004019697T patent/DE602004019697D1/de active Active
- 2004-12-22 US US10/583,896 patent/US20080045596A1/en not_active Abandoned
- 2004-12-22 JP JP2006546323A patent/JP2007515467A/ja not_active Withdrawn
- 2004-12-22 AT AT04806216T patent/ATE423765T1/de not_active IP Right Cessation
- 2004-12-22 EP EP04806216A patent/EP1716113B1/de not_active Not-in-force
- 2004-12-22 US US11/019,133 patent/US20050209336A1/en not_active Abandoned
- 2004-12-22 ES ES04806216T patent/ES2322765T3/es active Active
Also Published As
Publication number | Publication date |
---|---|
EP1716113B1 (de) | 2009-02-25 |
ES2322765T3 (es) | 2009-06-26 |
EP1716113A1 (de) | 2006-11-02 |
GB0329620D0 (en) | 2004-01-28 |
US20080045596A1 (en) | 2008-02-21 |
DE602004019697D1 (de) | 2009-04-09 |
JP2007515467A (ja) | 2007-06-14 |
US20050209336A1 (en) | 2005-09-22 |
WO2005061449A1 (en) | 2005-07-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |