ATE399795T1 - Verfahren zur herstellung verbesserter dextran- hemoglobin konjugate - Google Patents

Verfahren zur herstellung verbesserter dextran- hemoglobin konjugate

Info

Publication number
ATE399795T1
ATE399795T1 AT01973890T AT01973890T ATE399795T1 AT E399795 T1 ATE399795 T1 AT E399795T1 AT 01973890 T AT01973890 T AT 01973890T AT 01973890 T AT01973890 T AT 01973890T AT E399795 T1 ATE399795 T1 AT E399795T1
Authority
AT
Austria
Prior art keywords
dextran
producing improved
hemoglobin conjugates
hemoglobin
conjugates
Prior art date
Application number
AT01973890T
Other languages
English (en)
Inventor
Jeffrey Wong
Sheung Pun Tsai
Original Assignee
Dextro Sang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dextro Sang Corp filed Critical Dextro Sang Corp
Application granted granted Critical
Publication of ATE399795T1 publication Critical patent/ATE399795T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
AT01973890T 2000-09-19 2001-09-19 Verfahren zur herstellung verbesserter dextran- hemoglobin konjugate ATE399795T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002319966A CA2319966A1 (en) 2000-09-19 2000-09-19 Improved dextran-hemoglobin conjugate as potential blood substitute

Publications (1)

Publication Number Publication Date
ATE399795T1 true ATE399795T1 (de) 2008-07-15

Family

ID=4167162

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01973890T ATE399795T1 (de) 2000-09-19 2001-09-19 Verfahren zur herstellung verbesserter dextran- hemoglobin konjugate

Country Status (10)

Country Link
US (2) US20030073820A1 (de)
EP (1) EP1339749B1 (de)
JP (1) JP2004509168A (de)
CN (2) CN1668643A (de)
AT (1) ATE399795T1 (de)
AU (1) AU2001293554A1 (de)
CA (1) CA2319966A1 (de)
DE (1) DE60134661D1 (de)
WO (1) WO2002024751A1 (de)
ZA (1) ZA200305580B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110251265A1 (en) * 2010-04-02 2011-10-13 Alberta Innovates - Technology Futures Polyamine-containing polymers and methods of synthesis and use
EP2967411B1 (de) 2013-03-14 2021-03-10 Gyrus Acmi Inc. Chirurgische positionierungsschaltung
EP3092213B1 (de) 2013-12-27 2019-10-23 Virginia Commonwealth University Allosterische hämoglobin-modifikatoren mit stickoxidfreisetzendem teil
US10859563B2 (en) 2015-12-01 2020-12-08 General Electric Company Erythrocyte aggregation and leukocyte isolation
CN106620663B (zh) * 2017-02-05 2020-05-19 中国医学科学院生物医学工程研究所 糖-血红蛋白纳米粒子的制备方法及用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1055932A (en) * 1975-10-22 1979-06-05 Hematech Inc. Blood substitute based on hemoglobin
GB8328917D0 (en) * 1983-10-28 1983-11-30 Fisons Plc Blood substitute
FR2600894B1 (fr) * 1986-07-02 1989-01-13 Centre Nat Rech Scient Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
FR2630329B1 (fr) * 1988-04-20 1991-07-05 Merieux Inst Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
CA2233725A1 (en) * 1998-03-31 1999-09-30 Hemosol Inc. Hemoglobin-hydroxyethyl starch complexes

Also Published As

Publication number Publication date
CN101569749A (zh) 2009-11-04
WO2002024751A1 (en) 2002-03-28
US20030073820A1 (en) 2003-04-17
CN1668643A (zh) 2005-09-14
CN101569749B (zh) 2011-07-13
DE60134661D1 (de) 2008-08-14
US7307150B2 (en) 2007-12-11
JP2004509168A (ja) 2004-03-25
EP1339749A1 (de) 2003-09-03
CA2319966A1 (en) 2002-03-19
AU2001293554A1 (en) 2002-04-02
US20050113289A1 (en) 2005-05-26
EP1339749B1 (de) 2008-07-02
ZA200305580B (en) 2004-07-19

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