ATE384800T1 - Multifunktionelle protease-inhibitoren und deren verwendung zur behandlung von krankheiten - Google Patents

Multifunktionelle protease-inhibitoren und deren verwendung zur behandlung von krankheiten

Info

Publication number
ATE384800T1
ATE384800T1 AT01988344T AT01988344T ATE384800T1 AT E384800 T1 ATE384800 T1 AT E384800T1 AT 01988344 T AT01988344 T AT 01988344T AT 01988344 T AT01988344 T AT 01988344T AT E384800 T1 ATE384800 T1 AT E384800T1
Authority
AT
Austria
Prior art keywords
fusion proteins
treatment
protease
protease inhibitors
diseases
Prior art date
Application number
AT01988344T
Other languages
English (en)
Inventor
Philip Barr
Helen Gibson
Philip Pemberton
Original Assignee
Arriva Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arriva Pharmaceuticals Inc filed Critical Arriva Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE384800T1 publication Critical patent/ATE384800T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
AT01988344T 2000-12-18 2001-12-18 Multifunktionelle protease-inhibitoren und deren verwendung zur behandlung von krankheiten ATE384800T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25669900P 2000-12-18 2000-12-18
US33196601P 2001-11-20 2001-11-20

Publications (1)

Publication Number Publication Date
ATE384800T1 true ATE384800T1 (de) 2008-02-15

Family

ID=26945535

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01988344T ATE384800T1 (de) 2000-12-18 2001-12-18 Multifunktionelle protease-inhibitoren und deren verwendung zur behandlung von krankheiten

Country Status (7)

Country Link
EP (1) EP1366175B1 (de)
JP (2) JP4426179B2 (de)
AT (1) ATE384800T1 (de)
AU (2) AU2002241661B2 (de)
CA (1) CA2430973A1 (de)
DE (1) DE60132632T2 (de)
WO (1) WO2002050287A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2508762A1 (en) * 2002-12-06 2004-06-24 Arriva Pharmaceuticals, Inc. Methods and compositions for treatment of otitis media
WO2004089987A1 (en) * 2003-04-08 2004-10-21 Genova Ltd. Secreted polypeptide species associated with cardiovascular disorders
EP1660661A2 (de) 2003-08-08 2006-05-31 Arriva Pharmaceuticals, Inc. Verfahren zur proteinproduktion in hefe
SE0302559D0 (sv) 2003-09-25 2003-09-25 Astrazeneca Ab Method
AU2005221151A1 (en) 2004-03-09 2005-09-22 Arriva Pharmaceuticals, Inc. Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor
JP2007037434A (ja) * 2005-08-02 2007-02-15 Yamaguchi Univ 膵β細胞特異的に発現される人工タンパク質、該タンパク質をコードしたレポーター遺伝子及び膵β細胞量の計測方法
JP2009532369A (ja) * 2006-03-30 2009-09-10 リサーチ ファウンデーション オブ シティ ユニバーシティ オブ ニューヨーク 分泌性白血球プロテアーゼインヒビターによる神経再生の刺激
US8802627B2 (en) 2008-10-09 2014-08-12 Oriental Yeast Co., Ltd. Fusion protein composed of matrix metalloproteinase-2 inhibitor peptide derived from amyloid-B precursor protein and tissue inhibitor of metalloproteinase-2
EP2616487B1 (de) * 2010-09-14 2015-03-25 F.Hoffmann-La Roche Ag Serpin-finger-fusionspolypeptid
AU2012275287B2 (en) 2011-06-28 2017-10-05 Inhibrx, Inc. Serpin fusion polypeptides and methods of use thereof
US10400029B2 (en) 2011-06-28 2019-09-03 Inhibrx, Lp Serpin fusion polypeptides and methods of use thereof
SG10201610913PA (en) 2011-12-30 2017-02-27 Grifols Sa Alpha1-proteinase inhibitor for delaying the onset or progression of pulmonary exacerbations
JP6436401B2 (ja) * 2013-04-30 2018-12-12 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク 弾性繊維損傷マーカーの解析
US20160235813A1 (en) * 2013-09-18 2016-08-18 James Cook University Anti-inflammatory proteins and methods of use
CN105745223A (zh) 2013-09-18 2016-07-06 詹姆斯库克大学 修饰的抗炎蛋白及使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900400A (en) * 1984-12-06 1999-05-04 Amgen Inc. Serine protease inhibitor analogs
DE3709255A1 (de) * 1987-03-20 1988-09-29 Hoechst Ag Hybridserpine und dafuer kodierende dna
US5633227A (en) * 1994-09-12 1997-05-27 Miles, Inc. Secretory leukocyte protease inhibitor as an inhibitor of tryptase
EP0981606A2 (de) * 1997-05-12 2000-03-01 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Verfahren und vektor zur hemmung der zell-migration
EP1231936A2 (de) * 1999-10-27 2002-08-21 K-Quay Enterprises, LLC Verfahren und zusammensetzungen für behandlung von keratokonus mit proteaseinhibitoren

Also Published As

Publication number Publication date
AU4166102A (en) 2002-07-01
AU2002241661B2 (en) 2007-05-31
JP4426179B2 (ja) 2010-03-03
CA2430973A1 (en) 2002-06-27
EP1366175B1 (de) 2008-01-23
EP1366175A2 (de) 2003-12-03
JP2009297031A (ja) 2009-12-24
JP2004537970A (ja) 2004-12-24
WO2002050287A3 (en) 2003-09-18
DE60132632D1 (de) 2008-03-13
DE60132632T2 (de) 2009-01-22
WO2002050287A2 (en) 2002-06-27

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