ATE371027T1 - Expressions- und sekretionsvektor für menschliches interferon alpha und verfahren zur herstellung von interferon alpha durch anwendung desselben - Google Patents
Expressions- und sekretionsvektor für menschliches interferon alpha und verfahren zur herstellung von interferon alpha durch anwendung desselbenInfo
- Publication number
- ATE371027T1 ATE371027T1 AT01949005T AT01949005T ATE371027T1 AT E371027 T1 ATE371027 T1 AT E371027T1 AT 01949005 T AT01949005 T AT 01949005T AT 01949005 T AT01949005 T AT 01949005T AT E371027 T1 ATE371027 T1 AT E371027T1
- Authority
- AT
- Austria
- Prior art keywords
- interferon alpha
- human interferon
- hifnalpha
- same
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020000002434A KR100360594B1 (ko) | 2000-01-19 | 2000-01-19 | 인간 인터페론 알파의 발현 분비벡터 및 이를 이용한인터페론 알파의 생산 방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE371027T1 true ATE371027T1 (de) | 2007-09-15 |
Family
ID=19639684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01949005T ATE371027T1 (de) | 2000-01-19 | 2001-01-19 | Expressions- und sekretionsvektor für menschliches interferon alpha und verfahren zur herstellung von interferon alpha durch anwendung desselben |
Country Status (14)
Country | Link |
---|---|
US (1) | US7052867B2 (de) |
EP (1) | EP1250439B1 (de) |
JP (1) | JP3751883B2 (de) |
KR (1) | KR100360594B1 (de) |
CN (1) | CN100436581C (de) |
AT (1) | ATE371027T1 (de) |
AU (1) | AU762053B2 (de) |
BR (1) | BRPI0107708A8 (de) |
CA (1) | CA2397527C (de) |
DE (1) | DE60130100T2 (de) |
ES (1) | ES2290156T3 (de) |
NZ (1) | NZ520076A (de) |
RU (1) | RU2230116C2 (de) |
WO (1) | WO2001057217A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602004004796T2 (de) * | 2003-08-13 | 2007-12-06 | Sandoz Ag | Expressionsvektoren, transformierte wirtszellen und fermentationsverfahren zur herstellung rekombinanter polypeptide |
WO2005017174A2 (en) * | 2003-08-13 | 2005-02-24 | Sandoz Ag | Process for the purification of recombinant polypeptides |
GB0319601D0 (en) * | 2003-08-20 | 2003-09-24 | Sandoz Ag | Production process |
ATE522548T1 (de) | 2003-11-13 | 2011-09-15 | Hanmi Holdings Co Ltd | Verfahren zur massenproduktion der konstanten region von immunglobulin |
US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
EP2195338B1 (de) * | 2007-10-01 | 2013-12-25 | Pharmaessentia Corp. | N-terminal modifiziertes interferon-alpha |
FR2964434B1 (fr) | 2010-09-07 | 2012-08-24 | Walden Associates Ltd S A | Amortisseur a haut pouvoir dissipatif et pratiquement sans huile |
RU2622077C2 (ru) | 2011-09-05 | 2017-06-09 | Ханми Сайенс Ко., Лтд. | Фармацевтическая композиция для лечения рака, содержащая конъюгат интерферона-альфа |
US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3586386T2 (de) | 1984-10-05 | 1993-01-14 | Genentech Inc | Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung. |
JPS63230089A (ja) | 1987-03-18 | 1988-09-26 | Takeda Chem Ind Ltd | 分泌発現による蛋白質の製造法 |
EP0626448A3 (de) * | 1993-05-26 | 1998-01-14 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Verfahren zur Herstellung und Reinigung von alpha-Interferon |
US5470719A (en) * | 1994-03-18 | 1995-11-28 | Meng; Shi-Yuan | Modified OmpA signal sequence for enhanced secretion of polypeptides |
KR100316347B1 (ko) * | 1998-09-15 | 2002-08-27 | 한미약품(주) | 대장균엔테로톡신ⅱ신호펩티드의변형체와인체성장호르몬의융합단백질을발현하는재조합미생물및그를이용한인체성장호르몬의제조방법 |
-
2000
- 2000-01-19 KR KR1020000002434A patent/KR100360594B1/ko active IP Right Grant
-
2001
- 2001-01-19 CN CNB018038603A patent/CN100436581C/zh not_active Expired - Fee Related
- 2001-01-19 CA CA2397527A patent/CA2397527C/en not_active Expired - Lifetime
- 2001-01-19 NZ NZ520076A patent/NZ520076A/en not_active IP Right Cessation
- 2001-01-19 AU AU28909/01A patent/AU762053B2/en not_active Ceased
- 2001-01-19 EP EP01949005A patent/EP1250439B1/de not_active Expired - Lifetime
- 2001-01-19 DE DE60130100T patent/DE60130100T2/de not_active Expired - Lifetime
- 2001-01-19 RU RU2002122088/13A patent/RU2230116C2/ru not_active IP Right Cessation
- 2001-01-19 JP JP2001558031A patent/JP3751883B2/ja not_active Expired - Fee Related
- 2001-01-19 US US10/182,040 patent/US7052867B2/en not_active Expired - Lifetime
- 2001-01-19 BR BRPI0107708A patent/BRPI0107708A8/pt not_active Application Discontinuation
- 2001-01-19 AT AT01949005T patent/ATE371027T1/de not_active IP Right Cessation
- 2001-01-19 WO PCT/KR2001/000097 patent/WO2001057217A1/en active IP Right Grant
- 2001-01-19 ES ES01949005T patent/ES2290156T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2003521925A (ja) | 2003-07-22 |
DE60130100T2 (de) | 2008-05-15 |
AU762053B2 (en) | 2003-06-19 |
EP1250439A4 (de) | 2004-04-07 |
US20040151695A1 (en) | 2004-08-05 |
CN100436581C (zh) | 2008-11-26 |
WO2001057217A1 (en) | 2001-08-09 |
CA2397527A1 (en) | 2001-08-09 |
KR100360594B1 (ko) | 2002-11-13 |
JP3751883B2 (ja) | 2006-03-01 |
AU2890901A (en) | 2001-08-14 |
EP1250439A1 (de) | 2002-10-23 |
RU2230116C2 (ru) | 2004-06-10 |
BR0107708A (pt) | 2002-11-19 |
CA2397527C (en) | 2010-10-19 |
EP1250439B1 (de) | 2007-08-22 |
US7052867B2 (en) | 2006-05-30 |
BRPI0107708A8 (pt) | 2016-06-07 |
CN1418251A (zh) | 2003-05-14 |
WO2001057217A9 (en) | 2002-12-27 |
DE60130100D1 (de) | 2007-10-04 |
ES2290156T3 (es) | 2008-02-16 |
NZ520076A (en) | 2003-07-25 |
KR20010073658A (ko) | 2001-08-01 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |