ATE366309T1 - Caspasen-aktivatoren - Google Patents

Caspasen-aktivatoren

Info

Publication number
ATE366309T1
ATE366309T1 AT01900896T AT01900896T ATE366309T1 AT E366309 T1 ATE366309 T1 AT E366309T1 AT 01900896 T AT01900896 T AT 01900896T AT 01900896 T AT01900896 T AT 01900896T AT E366309 T1 ATE366309 T1 AT E366309T1
Authority
AT
Austria
Prior art keywords
activators
caspases
sequences
polypeptide
diagnostic
Prior art date
Application number
AT01900896T
Other languages
English (en)
Inventor
Xiaodong Wang
Chunying Du
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE366309T1 publication Critical patent/ATE366309T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT01900896T 2000-01-06 2001-01-05 Caspasen-aktivatoren ATE366309T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/479,309 US6110691A (en) 2000-01-06 2000-01-06 Activators of caspases

Publications (1)

Publication Number Publication Date
ATE366309T1 true ATE366309T1 (de) 2007-07-15

Family

ID=23903477

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01900896T ATE366309T1 (de) 2000-01-06 2001-01-05 Caspasen-aktivatoren

Country Status (9)

Country Link
US (2) US6110691A (de)
EP (1) EP1244787B1 (de)
JP (1) JP3851819B2 (de)
AT (1) ATE366309T1 (de)
AU (1) AU2630701A (de)
CA (1) CA2395344C (de)
DE (1) DE60129202T2 (de)
ES (1) ES2288924T3 (de)
WO (1) WO2001049719A2 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166475B2 (en) * 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
WO2001016373A2 (en) * 1999-08-27 2001-03-08 Mitokor Assaying of mitochondrial intermembrane space protein translocation
US7163801B2 (en) * 1999-09-01 2007-01-16 The Burnham Institute Methods for determining the prognosis for cancer patients using tucan
US6608026B1 (en) 2000-08-23 2003-08-19 Board Of Regents, The University Of Texas System Apoptotic compounds
US20020132786A1 (en) * 2000-08-24 2002-09-19 Alnemri Emad S. IAP binding peptide or polypeptide and methods of using the same
WO2002096930A2 (en) * 2001-05-31 2002-12-05 The Trustees Of Princeton University Iap binding peptides and assays for identifying compounds that bind iap
US6992063B2 (en) * 2000-09-29 2006-01-31 The Trustees Of Princeton University Compositions and method for regulating apoptosis
AU2002244247B2 (en) 2001-03-01 2007-12-13 Harbor Biosciences, Inc. Use of certain steroids for treatment of blood cell deficiencies
ATE366938T1 (de) * 2001-05-07 2007-08-15 Burnham Inst Verfahren zur bestimmung der prognose von krebspatienten mittels tucan
US7361310B1 (en) * 2001-11-30 2008-04-22 Northwestern University Direct write nanolithographic deposition of nucleic acids from nanoscopic tips
EP1354952A1 (de) * 2002-04-17 2003-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-Peptide zur Verwendung als therapeutische Mittel gegen Krebs und Autoimmunerkrankungen
WO2003086470A2 (en) * 2002-04-17 2003-10-23 Deutsches Krebsforschungszentrum Smac-peptides as therapeutics against cancer and autoimmune diseases
EP1354953A1 (de) * 2002-04-17 2003-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-Peptide zur Verwendung als therapeutische Mittel gegen Krebs und Autoimmunerkrankungen
WO2004066958A2 (en) * 2003-01-30 2004-08-12 The Trustees Of Princeton University Caspase-9:bir3 domain of xiap complexes and methods of use
US20050233411A9 (en) * 2003-02-07 2005-10-20 Chunying Du Compositions and methods for cleaving IAP
US20080199439A1 (en) * 2003-02-12 2008-08-21 Mclendon George L IAP-binding cargo molecules and peptidomimetics for use in diagnostic and therapeutic methods
FR2857098B1 (fr) * 2003-07-04 2006-05-05 Inst Nat Sante Rech Med Procede de mise en evidence d'un evenement moleculaire dans une cellule grace a des proteines marqueurs fluorescentes.
ES2475207T3 (es) 2004-07-15 2014-07-10 Tetralogic Pharmaceuticals Corporation Compuestos de unión a IAP
US20060019335A1 (en) * 2004-07-20 2006-01-26 Chunying Du Compositions and methods to promote c-IAP autodegradation
WO2006034454A1 (en) * 2004-09-23 2006-03-30 The Trustees Of The University Of Princeton Bcl-2 family member and bh-3 only proteins for use in development of peptidomimetics
AU2006216450C1 (en) 2005-02-25 2013-01-10 Medivir Ab Dimeric IAP inhibitors
JP4954983B2 (ja) * 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
WO2008134474A2 (en) 2007-04-27 2008-11-06 The Board Of Trustees Of The University Of Illinois Compositions and methods including cell death inducers and procaspase activation
US20070049602A1 (en) 2005-05-26 2007-03-01 The Board Of Trustees Of The University Of Illinois Selective Apoptotic Induction in Cancer Cells Including Activation of Procaspase-3
AU2006279929A1 (en) * 2005-08-09 2007-02-22 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
US20100256046A1 (en) * 2009-04-03 2010-10-07 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
CA2564872C (en) 2005-10-25 2010-12-21 Aegera Therapeutics Inc. Iap bir domain binding compounds
TWI543988B (zh) * 2006-03-16 2016-08-01 科學製藥股份有限公司 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物
WO2007131366A1 (en) * 2006-05-16 2007-11-22 Aegera Therapeutics Inc. Iap bir domain binding compounds
WO2008014236A1 (en) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
WO2008014238A2 (en) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
BRPI0715195A2 (pt) * 2006-07-24 2013-06-11 Tetralogic Pharm Corp composto, mÉtodos para induzir e para estimular a apoptose em uma cÉlula, para intensificar a apoptose de cÉlulas patogÊnicas in vivo em um indivÍduo, e para tratar uma doenÇa, e, composiÇço farmacÊutica
US8143426B2 (en) * 2006-07-24 2012-03-27 Tetralogic Pharmaceuticals Corporation IAP inhibitors
WO2008014240A2 (en) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
WO2008144925A1 (en) * 2007-05-30 2008-12-04 Aegera Therapeutics Inc. Iap bir domain binding compounds
WO2009136290A1 (en) * 2008-05-05 2009-11-12 Aegera Therapeutics, Inc. Functionalized pyrrolidines and use thereof as iap inhibitors
CA2728933A1 (en) * 2008-06-27 2009-12-30 Aegera Therapeutics Inc. Bridged secondary amines and use thereof as iap bir domain binding compounds
EP2393794B1 (de) 2009-02-09 2017-03-22 The Board of Trustees of the University of Illionis Entwicklung, synthese und bewertung von procaspaseaktivierenden verbindungen als personalisierte antikrebsmittel
US8283372B2 (en) * 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
AU2011214057B2 (en) 2010-02-12 2016-11-17 Pharmascience Inc. IAP BIR domain binding compounds
US8916705B2 (en) 2011-10-14 2014-12-23 The Board of Trustees of The University of Illilnois Procaspase-activating compounds and compositions
AU2013225682B2 (en) 2012-03-02 2016-04-14 The Board Of Trustees Of The University Of Illinois Potent anticancer activity via dual compound activation
EP3290035B1 (de) 2012-03-06 2019-05-15 The Board of Trustees of the University of Illinois Procaspase kombinationstherapie zur behandlung von krebs
CN104507479B (zh) 2012-03-06 2017-08-18 伊利诺伊大学评议会 通过联合治疗的半胱天冬酶‑3酶原激活
RU2578545C1 (ru) * 2015-01-12 2016-03-27 Федеральное государственное бюджетное научное учреждение "Восточно-Сибирский институт медико-экологических исследований" Способ оценки токсического действия наночастиц серебра, инкапсулированных в полимерную матрицу арабиногалактана, на ткань головного мозга лабораторных животных в отдаленном периоде воздействия
RU2621122C1 (ru) * 2016-04-25 2017-05-31 Федеральное государственное бюджетное научное учреждение "Восточно-Сибирский институт медико-экологических исследований" Способ оценки процесса апоптоза в ткани головного мозга лабораторных животных
CN111491927A (zh) 2017-11-17 2020-08-04 伊利诺伊大学董事会 通过降解双mek信号传导的癌症疗法
JP2022504184A (ja) 2018-10-05 2022-01-13 ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ ブドウ膜黒色腫の治療のための併用療法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1003856A1 (de) * 1997-06-05 2000-05-31 Board of Regents, The University of Texas System Apaf-1, menschluches ced-4 homolog, ein aktivator von caspase-3
AU3395900A (en) * 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides

Also Published As

Publication number Publication date
CA2395344C (en) 2012-05-22
JP2003518943A (ja) 2003-06-17
US6110691A (en) 2000-08-29
EP1244787A2 (de) 2002-10-02
WO2001049719A3 (en) 2002-02-07
CA2395344A1 (en) 2001-07-12
JP3851819B2 (ja) 2006-11-29
ES2288924T3 (es) 2008-02-01
DE60129202D1 (de) 2007-08-16
AU2630701A (en) 2001-07-16
EP1244787B1 (de) 2007-07-04
US6534267B1 (en) 2003-03-18
DE60129202T2 (de) 2008-03-06
WO2001049719A2 (en) 2001-07-12

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