ATE355291T1 - A2a adenosinrezeptorantagonisten - Google Patents
A2a adenosinrezeptorantagonistenInfo
- Publication number
- ATE355291T1 ATE355291T1 AT02805189T AT02805189T ATE355291T1 AT E355291 T1 ATE355291 T1 AT E355291T1 AT 02805189 T AT02805189 T AT 02805189T AT 02805189 T AT02805189 T AT 02805189T AT E355291 T1 ATE355291 T1 AT E355291T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- sup
- receptor antagonists
- adenosine receptor
- sub
- Prior art date
Links
- 229940121359 adenosine receptor antagonist Drugs 0.000 title abstract 2
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 title abstract 2
- 101150051188 Adora2a gene Proteins 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34245501P | 2001-12-18 | 2001-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE355291T1 true ATE355291T1 (de) | 2006-03-15 |
Family
ID=23341901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02805189T ATE355291T1 (de) | 2001-12-18 | 2002-12-18 | A2a adenosinrezeptorantagonisten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7189730B2 (de) |
| EP (1) | EP1456209B1 (de) |
| AT (1) | ATE355291T1 (de) |
| AU (1) | AU2002357295A1 (de) |
| DE (1) | DE60218525T2 (de) |
| ES (1) | ES2279903T3 (de) |
| WO (1) | WO2003051882A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7157465B2 (en) * | 2001-04-17 | 2007-01-02 | Dainippon Simitomo Pharma Co., Ltd. | Adenine derivatives |
| KR100883292B1 (ko) * | 2001-06-29 | 2009-02-11 | 씨브이 쎄러퓨틱스, 인코포레이티드 | Ａ２ｂ 아데노신 수용체 길항제로서의 퓨린 유도체 |
| NL1023355C2 (nl) * | 2003-05-07 | 2004-11-09 | Oce Tech Bv | Hot melt inkt omvattend een mengsel van kleurstoffen. |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| WO2009034386A1 (en) * | 2007-09-13 | 2009-03-19 | Astrazeneca Ab | Derivatives of adenine and 8-aza-adenine and uses thereof-796 |
| KR20110042153A (ko) * | 2008-05-30 | 2011-04-25 | 제넨테크, 인크. | 퓨린 ｐｉ３ｋ 억제 화합물 및 사용 방법 |
| AU2010242394B2 (en) * | 2009-04-28 | 2014-05-15 | Zenyaku Kogyo Kabushikikaisha | Purine derivative and antitumor agent using same |
| MX2012000113A (es) | 2009-06-30 | 2012-02-29 | Forest Lab Holdings Ltd | Compuestos alcoxi-carbonil-amino-alquinil-adenosina y derivados de los mismos como agonistas a2ar. |
| WO2017188287A1 (ja) * | 2016-04-26 | 2017-11-02 | 大日本住友製薬株式会社 | 置換プリン誘導体 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9125001D0 (en) * | 1991-11-25 | 1992-01-22 | Ici Plc | Heterocyclic compounds |
| US5866702A (en) | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| US6329381B1 (en) * | 1997-11-28 | 2001-12-11 | Sumitomo Pharmaceuticals Company, Limited | Heterocyclic compounds |
| ES2246829T3 (es) | 1999-02-01 | 2006-03-01 | Cv Therapeutics Inc | Inhibidores purinicos de cinasa 2 y de ikb-alfa dependientes de ciclina. |
| WO2001002400A1 (en) * | 1999-07-02 | 2001-01-11 | Eisai Co., Ltd. | Fused imidazole compounds and remedies for diabetes mellitus |
| CA2396276A1 (en) | 2000-01-07 | 2001-07-12 | Universitaire Instelling Antwerpen | Purine derivatives, process for their preparation and use thereof |
| US7157465B2 (en) * | 2001-04-17 | 2007-01-02 | Dainippon Simitomo Pharma Co., Ltd. | Adenine derivatives |
| KR100883292B1 (ko) * | 2001-06-29 | 2009-02-11 | 씨브이 쎄러퓨틱스, 인코포레이티드 | Ａ２ｂ 아데노신 수용체 길항제로서의 퓨린 유도체 |
| ITRM20010465A1 (it) * | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam |
-
2002
- 2002-12-18 ES ES02805189T patent/ES2279903T3/es not_active Expired - Lifetime
- 2002-12-18 AU AU2002357295A patent/AU2002357295A1/en not_active Abandoned
- 2002-12-18 DE DE60218525T patent/DE60218525T2/de not_active Expired - Lifetime
- 2002-12-18 WO PCT/US2002/040361 patent/WO2003051882A1/en not_active Ceased
- 2002-12-18 US US10/322,985 patent/US7189730B2/en not_active Expired - Fee Related
- 2002-12-18 EP EP02805189A patent/EP1456209B1/de not_active Expired - Lifetime
- 2002-12-18 AT AT02805189T patent/ATE355291T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1456209B1 (de) | 2007-02-28 |
| WO2003051882A1 (en) | 2003-06-26 |
| DE60218525D1 (de) | 2007-04-12 |
| US20030149060A1 (en) | 2003-08-07 |
| AU2002357295A1 (en) | 2003-06-30 |
| EP1456209A1 (de) | 2004-09-15 |
| US7189730B2 (en) | 2007-03-13 |
| ES2279903T3 (es) | 2007-09-01 |
| DE60218525T2 (de) | 2007-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |