ATE354676T1 - Invivo selektionsverfahren zur bestimmung von inhibierenden rna molekülen - Google Patents
Invivo selektionsverfahren zur bestimmung von inhibierenden rna molekülenInfo
- Publication number
- ATE354676T1 ATE354676T1 AT00935391T AT00935391T ATE354676T1 AT E354676 T1 ATE354676 T1 AT E354676T1 AT 00935391 T AT00935391 T AT 00935391T AT 00935391 T AT00935391 T AT 00935391T AT E354676 T1 ATE354676 T1 AT E354676T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleotide sequence
- binding
- invivo
- rna molecules
- sequences
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000010187 selection method Methods 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 7
- 125000003729 nucleotide group Chemical group 0.000 abstract 7
- 108091026890 Coding region Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 2
- 108020004999 messenger RNA Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000007017 scission Effects 0.000 abstract 2
- 238000013518 transcription Methods 0.000 abstract 2
- 230000035897 transcription Effects 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9912965.2A GB9912965D0 (en) | 1999-06-03 | 1999-06-03 | In vivo selection method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE354676T1 true ATE354676T1 (de) | 2007-03-15 |
Family
ID=10854706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00935391T ATE354676T1 (de) | 1999-06-03 | 2000-06-02 | Invivo selektionsverfahren zur bestimmung von inhibierenden rna molekülen |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20020147169A1 (de) |
| EP (1) | EP1180167B1 (de) |
| JP (1) | JP2003501070A (de) |
| KR (1) | KR20020008178A (de) |
| CN (1) | CN1353769A (de) |
| AT (1) | ATE354676T1 (de) |
| AU (1) | AU762957B2 (de) |
| CA (1) | CA2374664A1 (de) |
| DE (1) | DE60033517T2 (de) |
| GB (2) | GB9912965D0 (de) |
| WO (1) | WO2000075370A1 (de) |
| ZA (1) | ZA200108397B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001289079A1 (en) * | 2000-09-13 | 2002-03-26 | Praecis Pharmaceuticals Incorporated | Pharmaceutical compositions for sustained drug delivery |
| AU9456201A (en) * | 2000-09-15 | 2002-03-26 | Merck & Co Inc | Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications |
| EP1504108B1 (de) | 2002-02-01 | 2013-04-17 | Oxford Biomedica (UK) Limited | Lentiviraler Vektor |
| JP2007535579A (ja) * | 2004-04-29 | 2007-12-06 | イェール ユニバーシティ | 炎症性疾患およびウイルス関連性呼吸器疾患を処置するためのヌクレアーゼ耐性外部ガイド配列 |
| WO2012151503A2 (en) * | 2011-05-04 | 2012-11-08 | The Broad Institute, Inc. | Multiplexed genetic reporter assays and compositions |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624824A (en) * | 1989-03-24 | 1997-04-29 | Yale University | Targeted cleavage of RNA using eukaryotic ribonuclease P and external guide sequence |
| WO1992001806A1 (en) * | 1990-07-16 | 1992-02-06 | The Public Health Research Institute Of The City Of New York, Inc. | Selection of ribozymes that efficiently cleave target rna |
| US6569432B1 (en) * | 1995-02-24 | 2003-05-27 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
| US5869248A (en) * | 1994-03-07 | 1999-02-09 | Yale University | Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences |
| AUPM516994A0 (en) * | 1994-04-20 | 1994-05-12 | Gene Shears Pty. Limited | An in vivo gene expression system |
| EP0770143A4 (de) * | 1994-06-15 | 1999-09-01 | Univ Columbia | Methode zur identifizierung von tumorsuppressorgenen |
| DE4424761C1 (de) * | 1994-07-04 | 1995-06-08 | Max Planck Gesellschaft | Expressionskassette für die Antisense- und die Ribozym-Expression |
| DE4424762C1 (de) * | 1994-07-04 | 1995-07-27 | Max Planck Gesellschaft | Ribozym-Bibliothek, ihre Herstellung und ihre Verwendung |
| US6130092A (en) * | 1994-07-04 | 2000-10-10 | Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. | Ribozyme gene library and method for making |
| CN100390290C (zh) * | 1995-11-13 | 2008-05-28 | 宝生物工程株式会社 | 用逆转录病毒将基因转入靶细胞的方法 |
| WO1998006440A2 (en) * | 1996-08-16 | 1998-02-19 | Innovir Laboratories, Inc. | Phenotypic conversion of cells mediated by external guide sequences |
| CA2283740C (en) * | 1997-03-14 | 2006-06-27 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
| CA2310510C (en) * | 1997-11-21 | 2007-04-17 | Yale University | Method for identifying and inhibiting functional nucleic acid molecules in cells |
| US6586180B1 (en) * | 1998-03-28 | 2003-07-01 | University Of Utah | Directed antisense libraries |
| US6156515A (en) * | 1999-02-09 | 2000-12-05 | Urocor, Inc. | Prostate-specific gene for diagnosis, prognosis and management of prostate cancer |
| GB9906177D0 (en) * | 1999-03-17 | 1999-05-12 | Oxford Biomedica Ltd | Anti-viral vectors |
| US20020002278A1 (en) * | 1999-11-05 | 2002-01-03 | Timothy W. Nilsen | Random intracellular method for obtaining optimally active nucleic acid molecules |
-
1999
- 1999-06-03 GB GBGB9912965.2A patent/GB9912965D0/en not_active Ceased
-
2000
- 2000-06-02 DE DE60033517T patent/DE60033517T2/de not_active Expired - Fee Related
- 2000-06-02 JP JP2001501649A patent/JP2003501070A/ja active Pending
- 2000-06-02 CN CN00808367A patent/CN1353769A/zh active Pending
- 2000-06-02 AT AT00935391T patent/ATE354676T1/de not_active IP Right Cessation
- 2000-06-02 GB GB0124449A patent/GB2364775A/en not_active Withdrawn
- 2000-06-02 WO PCT/GB2000/002136 patent/WO2000075370A1/en active IP Right Grant
- 2000-06-02 AU AU50935/00A patent/AU762957B2/en not_active Ceased
- 2000-06-02 KR KR1020017014193A patent/KR20020008178A/ko not_active Application Discontinuation
- 2000-06-02 CA CA002374664A patent/CA2374664A1/en not_active Abandoned
- 2000-06-02 EP EP00935391A patent/EP1180167B1/de not_active Expired - Lifetime
-
2001
- 2001-10-12 ZA ZA200108397A patent/ZA200108397B/xx unknown
- 2001-11-29 US US09/999,183 patent/US20020147169A1/en not_active Abandoned
-
2005
- 2005-04-28 US US11/116,779 patent/US20050221491A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU762957B2 (en) | 2003-07-10 |
| DE60033517D1 (de) | 2007-04-05 |
| EP1180167B1 (de) | 2007-02-21 |
| CA2374664A1 (en) | 2000-12-14 |
| GB0124449D0 (en) | 2001-12-05 |
| GB2364775A (en) | 2002-02-06 |
| EP1180167A1 (de) | 2002-02-20 |
| AU5093500A (en) | 2000-12-28 |
| US20050221491A1 (en) | 2005-10-06 |
| JP2003501070A (ja) | 2003-01-14 |
| CN1353769A (zh) | 2002-06-12 |
| US20020147169A1 (en) | 2002-10-10 |
| WO2000075370A1 (en) | 2000-12-14 |
| DE60033517T2 (de) | 2007-10-25 |
| KR20020008178A (ko) | 2002-01-29 |
| GB9912965D0 (en) | 1999-08-04 |
| ZA200108397B (en) | 2002-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lockard et al. | Mapping tRNA structure in solution using double-strand-specific ribonuclease V 1 from cobra venom | |
| Bram et al. | The ribonuclease III site flanking 23S sequences in the 30S ribosomal precursor RNA of E. coli | |
| Rhodes et al. | An underlying repeat in some transcriptional control sequences corresponding to half a double helical turn of DNA | |
| Higuchi et al. | DNA sequences from the quagga, an extinct member of the horse family | |
| Borgatti et al. | Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites | |
| Forbes et al. | Differential expression of multiple U1 small nuclear RNAs in oocytes and embryos of Xenopus laevis | |
| Barbacci et al. | The Structural Basis for the Specificity of Epidermal Growth Factor and Heregulin Binding (∗) | |
| BR0316435A (pt) | Produtos genéticos expressos diferencialmente em tumores e uso dos mesmos | |
| Nah et al. | Type II collagen mRNA containing an alternatively spliced exon predominates in the chick limb prior to chondrogenesis. | |
| Young | Transcription termination in the Escherichia coli ribosomal RNA operon rrnC. | |
| WO2004015062A3 (en) | Methods and compositions relating to gene silencing | |
| PT917571E (pt) | Gene relacionado com agouti | |
| Mackie | Nucleotide sequence of the gene for ribosomal protein S20 and its flanking regions. | |
| WO2000009734A3 (en) | Methods and compositions for use in spliceosome mediated rna trans-splicing | |
| ATE354676T1 (de) | Invivo selektionsverfahren zur bestimmung von inhibierenden rna molekülen | |
| Dahlberg et al. | Sequence of the promoter-operator proximal region of the major leftward RNA of bacteriophage lambda | |
| Legagneux et al. | Identification of RNA-binding proteins specific to Xenopus Eg maternal mRNAs: association with the portion of Eg2 mRNA that promotes deadenylation in embryos | |
| Wachter et al. | The leader sequence from the 5′-terminus to the A-protein initiation codon in MS2-virus RNA | |
| Łozinski et al. | Effect of the sequence-dependent structure of the 17 bp AT spacer on the strength of consensus-like E. coli promoters in vivo | |
| Brownlee et al. | The nucleotide sequence of the 5S RNA of chicken embryo fibroblasts | |
| Fang et al. | Native mRNA antisense-accessible sites library for the selection of antisense oligonucleotides, PNAs, and siRNAs | |
| DE60025011D1 (de) | Dna polymerase lambda und ihre verwendungen | |
| Ehresmann et al. | A topographical study of the 5′-region of 16 S RNA of Escherichia coli in the presence and absence of protein S4 | |
| BR9815277A (pt) | Fragmento de ácido nucléico isolado, gene quimérico, célula hospedeira transformada, homólogo de soja, método para alterar o nìvel de expressão de um homólogo do ativador de transcrição pvalf de phaseolus vulgaris em uma célula vegetal, método de obtenção de um fragmento de ácido nucléico e produto | |
| Pai et al. | Sequence and structural requirements for optimal guide RNA-directed insertional editing within Leishmania tarentolae |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |