ATE344322T1 - Verwendung von ribozymen zur bestimmung der funktion von genen - Google Patents
Verwendung von ribozymen zur bestimmung der funktion von genenInfo
- Publication number
- ATE344322T1 ATE344322T1 AT99907019T AT99907019T ATE344322T1 AT E344322 T1 ATE344322 T1 AT E344322T1 AT 99907019 T AT99907019 T AT 99907019T AT 99907019 T AT99907019 T AT 99907019T AT E344322 T1 ATE344322 T1 AT E344322T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- target nucleic
- phenotype
- expression
- function
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2399298A | 1998-02-13 | 1998-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE344322T1 true ATE344322T1 (de) | 2006-11-15 |
Family
ID=21818282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99907019T ATE344322T1 (de) | 1998-02-13 | 1999-02-12 | Verwendung von ribozymen zur bestimmung der funktion von genen |
Country Status (7)
Country | Link |
---|---|
US (2) | US6803194B1 (de) |
EP (1) | EP1053317B1 (de) |
AT (1) | ATE344322T1 (de) |
AU (1) | AU2678999A (de) |
CA (1) | CA2319112C (de) |
DE (1) | DE69933856D1 (de) |
WO (1) | WO1999041371A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
JP4118327B2 (ja) | 1994-08-20 | 2008-07-16 | ゲンダック・リミテッド | Dna認識のための結合タンパク質におけるまたはそれに関連する改良 |
GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
JP4309051B2 (ja) | 1998-03-02 | 2009-08-05 | マサチューセッツ インスティテュート オブ テクノロジー | 改善したリンカーを有するポリジンクフィンガータンパク質 |
US6977154B1 (en) | 1998-03-17 | 2005-12-20 | Gendaq Limited | Nucleic acid binding proteins |
US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
US7070934B2 (en) | 1999-01-12 | 2006-07-04 | Sangamo Biosciences, Inc. | Ligand-controlled regulation of endogenous gene expression |
US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US7030215B2 (en) | 1999-03-24 | 2006-04-18 | Sangamo Biosciences, Inc. | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
US20030104526A1 (en) | 1999-03-24 | 2003-06-05 | Qiang Liu | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
US6794136B1 (en) | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
ATE309536T1 (de) * | 1999-12-06 | 2005-11-15 | Sangamo Biosciences Inc | Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen |
AU2693501A (en) | 2000-01-24 | 2001-07-31 | Gendaq Ltd | Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules |
US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
AU2884102A (en) | 2000-12-07 | 2002-06-18 | Sangamo Biosciences Inc | Regulation of angiogenesis with zinc finger proteins |
CA2435394C (en) | 2001-01-22 | 2018-01-09 | Sangamo Biosciences, Inc. | Modified zinc finger binding proteins |
CA2434881A1 (en) * | 2001-02-02 | 2002-08-15 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Method for identifying functional nucleic acids |
US7262054B2 (en) | 2002-01-22 | 2007-08-28 | Sangamo Biosciences, Inc. | Zinc finger proteins for DNA binding and gene regulation in plants |
GB0202543D0 (en) * | 2002-02-04 | 2002-03-20 | Isis Innovation | Model systems |
US9943847B2 (en) | 2002-04-17 | 2018-04-17 | Cytonome/St, Llc | Microfluidic system including a bubble valve for regulating fluid flow through a microchannel |
US7157274B2 (en) * | 2002-06-24 | 2007-01-02 | Cytonome, Inc. | Method and apparatus for sorting particles |
US6976590B2 (en) | 2002-06-24 | 2005-12-20 | Cytonome, Inc. | Method and apparatus for sorting particles |
US6808075B2 (en) | 2002-04-17 | 2004-10-26 | Cytonome, Inc. | Method and apparatus for sorting particles |
US20070065808A1 (en) * | 2002-04-17 | 2007-03-22 | Cytonome, Inc. | Method and apparatus for sorting particles |
SI1536827T1 (sl) | 2002-08-14 | 2009-06-30 | Silence Therapeutics Ag | Uporaba protein-kinaze n beta |
US7361635B2 (en) | 2002-08-29 | 2008-04-22 | Sangamo Biosciences, Inc. | Simultaneous modulation of multiple genes |
US20050026172A1 (en) * | 2003-02-11 | 2005-02-03 | Immusol, Inc. | siRNA libraries optimized for predetermined protein families |
FR2852021B1 (fr) * | 2003-03-04 | 2007-12-07 | Methodes et outils pour le criblage d'arn actifs in cellulo | |
US7510856B2 (en) * | 2003-03-25 | 2009-03-31 | Hyman Edward D | Method for plasmid preparation by conversion of open circular plasmid to supercoiled plasmid |
US20050084938A1 (en) * | 2003-03-25 | 2005-04-21 | Hyman Edward D. | Method for plasmid preparation by conversion of open circular plasmid to supercoiled plasmid |
US9260693B2 (en) | 2004-12-03 | 2016-02-16 | Cytonome/St, Llc | Actuation of parallel microfluidic arrays |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
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US94324A (en) * | 1869-08-31 | Samuel lawrence | ||
US5504200A (en) | 1983-04-15 | 1996-04-02 | Mycogen Plant Science, Inc. | Plant gene expression |
US5272065A (en) | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
US5190931A (en) | 1983-10-20 | 1993-03-02 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
GB8626879D0 (en) | 1986-11-11 | 1986-12-10 | Ici Plc | Dna |
US5037746A (en) | 1986-12-03 | 1991-08-06 | University Patents, Inc. | RNA ribozyme polymerases, and methods |
US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
US5866701A (en) | 1988-09-20 | 1999-02-02 | The Board Of Regents For Northern Illinois University Of Dekalb | HIV targeted hairpin ribozymes |
US5217879A (en) | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
US5364678A (en) * | 1989-10-17 | 1994-11-15 | Malden Mills Industries, Inc. | Windproof and water resistant composite fabric with barrier layer |
US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
US5180818A (en) | 1990-03-21 | 1993-01-19 | The University Of Colorado Foundation, Inc. | Site specific cleavage of single-stranded dna |
JPH06502988A (ja) | 1990-07-26 | 1994-04-07 | ファウンデーション・フォー・リサーチ・アンド・テクノロジー ― ヘラス(エフオー.アール.ティー.エイチ.)インスティテュート・オブ・モレキュラー・バイオロジー・アンド・バイオテクノロジー | ポータブルリボザイムカセット、それを含有するdna配列、これらdna配列によりコードされるリボザイム、およびこれらリボザイムを含有する組成物 |
EP0550592B1 (de) | 1990-09-24 | 1997-01-15 | BRENT, Roger | Überprüfungsteste |
US5217889A (en) | 1990-10-19 | 1993-06-08 | Roninson Igor B | Methods and applications for efficient genetic suppressor elements |
US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
WO1994020618A1 (en) | 1993-03-09 | 1994-09-15 | Board Of Trustees Of The University Of Illinois | Genetic suppressor elements associated with sensitivity to chemotherapeutic drugs |
US5496698A (en) * | 1992-08-26 | 1996-03-05 | Ribozyme Pharmaceuticals, Inc. | Method of isolating ribozyme targets |
ES2176233T3 (es) | 1992-12-04 | 2002-12-01 | Univ Yale | Deteccion diagnostica amplificada con ribozimas. |
CA2163129A1 (en) | 1993-05-17 | 1994-11-24 | Flossie Wong-Staal | Ribozyme gene therapy for hiv infection and aids |
FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
US6133028A (en) | 1993-05-28 | 2000-10-17 | Transgene S.A. | Defective adenoviruses and corresponding complementation lines |
US5834256A (en) | 1993-06-11 | 1998-11-10 | Cell Genesys, Inc. | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells |
US5589362A (en) | 1993-06-14 | 1996-12-31 | Basf Aktiengesellschaft | Tetracycline regulated transcriptional modulators with altered DNA binding specificities |
US6514745B1 (en) * | 1993-07-19 | 2003-02-04 | The Regents Of The University Of California | Oncoprotein protein kinase |
US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
US5667969A (en) | 1993-11-12 | 1997-09-16 | University Research Corporation | Alteration of sequence of a deleterious target molecule by ribozyme catalyzed trans-splicing |
FR2712603B1 (fr) | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
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DE4424762C1 (de) * | 1994-07-04 | 1995-07-27 | Max Planck Gesellschaft | Ribozym-Bibliothek, ihre Herstellung und ihre Verwendung |
US6130092A (en) | 1994-07-04 | 2000-10-10 | Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. | Ribozyme gene library and method for making |
EP0707071B1 (de) | 1994-08-16 | 2003-07-30 | Crucell Holland B.V. | Von Adenovirus abgeleitete rekombinante Vektoren, für Gentherapie |
FR2723697B1 (fr) | 1994-08-17 | 1996-09-20 | Rhone Poulenc Rorer Sa | Methode de traitement de la restenose par la therapie genique |
US5599706A (en) | 1994-09-23 | 1997-02-04 | Stinchcomb; Dan T. | Ribozymes targeted to apo(a) mRNA |
DE69610310T2 (de) * | 1995-06-02 | 2001-03-15 | M & E Biotech As Horsholm | Verfahren zur identifikation von biologisch aktiven peptiden und nukleinsäuren |
ES2333425T5 (es) | 1995-06-15 | 2012-08-28 | Crucell Holland B.V. | Sistemas de empaquetado para adenovirus recombinante humano destinados a terapia génica |
US5679523A (en) | 1995-11-16 | 1997-10-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method for concurrent disruption of expression of multiple alleles of mammalian genes |
JP2001509661A (ja) | 1996-01-23 | 2001-07-24 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | トランス支配性細胞内作用因子ペプチドおよびrna分子のスクリーニング方法 |
US6255071B1 (en) | 1996-09-20 | 2001-07-03 | Cold Spring Harbor Laboratory | Mammalian viral vectors and their uses |
US6025192A (en) | 1996-09-20 | 2000-02-15 | Cold Spring Harbor Laboratory | Modified retroviral vectors |
GB2319773B (en) | 1996-11-30 | 2000-08-23 | Aea Technology Plc | Antisense vector |
CA2278734A1 (en) | 1997-01-23 | 1998-07-30 | Immusol Incorporated | Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries |
CA2288640A1 (en) * | 1997-05-09 | 1998-11-12 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids: synthesis, selection and use |
US6183959B1 (en) * | 1997-07-03 | 2001-02-06 | Ribozyme Pharmaceuticals, Inc. | Method for target site selection and discovery |
US6391311B1 (en) | 1998-03-17 | 2002-05-21 | Genentech, Inc. | Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1 |
AU758353B2 (en) | 1998-03-17 | 2003-03-20 | Genentech Inc. | Polypeptides homologous to VEGF and BMP1 |
US7091046B2 (en) | 2000-12-11 | 2006-08-15 | Hk Pharmaceuticals, Inc. | Multiplexed protein expression and activity assay |
-
1999
- 1999-02-12 DE DE69933856T patent/DE69933856D1/de not_active Expired - Lifetime
- 1999-02-12 WO PCT/US1999/003166 patent/WO1999041371A1/en active IP Right Grant
- 1999-02-12 AU AU26789/99A patent/AU2678999A/en not_active Abandoned
- 1999-02-12 EP EP99907019A patent/EP1053317B1/de not_active Expired - Lifetime
- 1999-02-12 AT AT99907019T patent/ATE344322T1/de not_active IP Right Cessation
- 1999-02-12 US US09/601,970 patent/US6803194B1/en not_active Expired - Fee Related
- 1999-02-12 CA CA002319112A patent/CA2319112C/en not_active Expired - Fee Related
-
2002
- 2002-09-16 US US10/244,715 patent/US20030087288A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1053317A1 (de) | 2000-11-22 |
CA2319112C (en) | 2003-10-28 |
DE69933856D1 (de) | 2006-12-14 |
EP1053317B1 (de) | 2006-11-02 |
CA2319112A1 (en) | 1999-08-19 |
WO1999041371A1 (en) | 1999-08-19 |
US6803194B1 (en) | 2004-10-12 |
AU2678999A (en) | 1999-08-30 |
US20030087288A1 (en) | 2003-05-08 |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |