ATE336582T1 - Polyketid-synthasen mit veränderter spezifität, ihre herstellung und verwendung - Google Patents

Polyketid-synthasen mit veränderter spezifität, ihre herstellung und verwendung

Info

Publication number
ATE336582T1
ATE336582T1 AT01956683T AT01956683T ATE336582T1 AT E336582 T1 ATE336582 T1 AT E336582T1 AT 01956683 T AT01956683 T AT 01956683T AT 01956683 T AT01956683 T AT 01956683T AT E336582 T1 ATE336582 T1 AT E336582T1
Authority
AT
Austria
Prior art keywords
preparation
polyketide synthases
altered specificity
alterations
specificity
Prior art date
Application number
AT01956683T
Other languages
English (en)
Inventor
Hrvoje Petkovic
Steven Gary Kendrew
Peter Francis Leadlay
Grange Road Pinehurst
Original Assignee
Biotica Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotica Tech Ltd filed Critical Biotica Tech Ltd
Application granted granted Critical
Publication of ATE336582T1 publication Critical patent/ATE336582T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT01956683T 2000-08-14 2001-08-14 Polyketid-synthasen mit veränderter spezifität, ihre herstellung und verwendung ATE336582T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0019986.9A GB0019986D0 (en) 2000-08-14 2000-08-14 Polyketides and their synthesis

Publications (1)

Publication Number Publication Date
ATE336582T1 true ATE336582T1 (de) 2006-09-15

Family

ID=9897580

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01956683T ATE336582T1 (de) 2000-08-14 2001-08-14 Polyketid-synthasen mit veränderter spezifität, ihre herstellung und verwendung

Country Status (10)

Country Link
US (1) US7595175B2 (de)
EP (1) EP1309695B1 (de)
JP (1) JP4933017B2 (de)
AT (1) ATE336582T1 (de)
AU (2) AU7860401A (de)
CA (1) CA2419538A1 (de)
DE (1) DE60122345T2 (de)
ES (1) ES2271057T3 (de)
GB (1) GB0019986D0 (de)
WO (1) WO2002014482A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170725A1 (en) 1993-09-20 2003-09-11 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
KR101016561B1 (ko) 2002-02-19 2011-02-22 다우 아그로사이언시즈 엘엘씨 신규한 스피노신 생산 폴리케타이드 신타제
WO2004007709A2 (en) 2002-07-16 2004-01-22 Biotica Technology Limited Production of polyketides
GB0327721D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Polyketides and their synthesis
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
EP2658855A2 (de) * 2010-12-31 2013-11-06 Acies Bio d.o.o. Neue polyketidverbindungen und verfahren zu ihrer herstellung
US11781128B2 (en) 2016-07-29 2023-10-10 Isomerase Therapeutics Limited Methods for producing hybrid polyketide synthase genes and polyketides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2341640A1 (en) 1998-07-02 2000-01-13 Chaitan Khosla Methods for making polyketides using altered pks
AU2002323061A1 (en) 2001-08-07 2003-02-24 Kosan Biosciences, Inc. Alteration of acyltransferase domain substrate specificity

Also Published As

Publication number Publication date
WO2002014482A3 (en) 2002-07-18
US20040023342A1 (en) 2004-02-05
JP2004506423A (ja) 2004-03-04
WO2002014482A2 (en) 2002-02-21
US7595175B2 (en) 2009-09-29
DE60122345T2 (de) 2007-08-30
AU7860401A (en) 2002-02-25
DE60122345D1 (de) 2006-09-28
AU2001278604B2 (en) 2005-10-06
JP4933017B2 (ja) 2012-05-16
GB0019986D0 (en) 2000-10-04
EP1309695A2 (de) 2003-05-14
ES2271057T3 (es) 2007-04-16
EP1309695B1 (de) 2006-08-16
CA2419538A1 (en) 2002-02-21

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