WO2007003397A3 - Method and nucleic acids for the improved treatment of cancers - Google Patents

Method and nucleic acids for the improved treatment of cancers Download PDF

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Publication number
WO2007003397A3
WO2007003397A3 PCT/EP2006/006458 EP2006006458W WO2007003397A3 WO 2007003397 A3 WO2007003397 A3 WO 2007003397A3 EP 2006006458 W EP2006006458 W EP 2006006458W WO 2007003397 A3 WO2007003397 A3 WO 2007003397A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
cancers
improved treatment
determining
lhx3
Prior art date
Application number
PCT/EP2006/006458
Other languages
French (fr)
Other versions
WO2007003397A2 (en
Inventor
Dimo Dietrich
Original Assignee
Epigenomics Ag
Dimo Dietrich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag, Dimo Dietrich filed Critical Epigenomics Ag
Publication of WO2007003397A2 publication Critical patent/WO2007003397A2/en
Publication of WO2007003397A3 publication Critical patent/WO2007003397A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Abstract

The present invention provides methods and nucleic acids for determining the prognosis and predicting treatment response of subjects with cancer. The expression of LHX3 or PITX3 is determined by determining the methylation status of one or more CpG positions within said genes.
PCT/EP2006/006458 2005-07-01 2006-07-03 Method and nucleic acids for the improved treatment of cancers WO2007003397A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP05090201.4 2005-07-01
EP05090202 2005-07-01
EP05090202.2 2005-07-01
EP05090201 2005-07-01
EP06090050 2006-04-07
EP06090050.3 2006-04-07
EP06090081 2006-05-18
EP06090081.8 2006-05-18

Publications (2)

Publication Number Publication Date
WO2007003397A2 WO2007003397A2 (en) 2007-01-11
WO2007003397A3 true WO2007003397A3 (en) 2007-05-18

Family

ID=37024195

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/006458 WO2007003397A2 (en) 2005-07-01 2006-07-03 Method and nucleic acids for the improved treatment of cancers

Country Status (1)

Country Link
WO (1) WO2007003397A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383803B2 (en) * 2008-08-11 2013-02-26 The University Of British Columbia PITX3 expression promoters
WO2011040532A1 (en) * 2009-10-02 2011-04-07 学校法人 久留米大学 Method for predicting therapeutic effect of immunotherapy on cancer patient and/or prognosis after immunotherapy, and gene set and kit to be used therein
CN102749448B (en) * 2012-07-27 2014-07-02 复旦大学附属中山医院 Kit for evaluating chemotherapy effect of lung adenocarcinoma
CN106990245B (en) * 2017-04-05 2018-07-31 东南大学 Detect application of the reagent of PITX1 expression quantity in preparing gastric cancer prognosis evaluation reagent kit

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077373A2 (en) * 2000-04-06 2001-10-18 Epigenomics Ag Detection of variations in the dna methylation profile
WO2002000927A2 (en) * 2000-06-30 2002-01-03 Epigenomics Ag Diagnosis of diseases associated with development by means of assessing their methylation status
WO2002040716A2 (en) * 2000-11-16 2002-05-23 Cemines, Llc Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes
US20040242510A1 (en) * 2001-10-05 2004-12-02 Markowitz Sanford D. Methods and compositions for detecting colon cancers
WO2005059172A2 (en) * 2003-12-11 2005-06-30 Epigenomics Ag Method and nucleic acids for the improved treatment of breast cell proliferative disorders

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077373A2 (en) * 2000-04-06 2001-10-18 Epigenomics Ag Detection of variations in the dna methylation profile
WO2002000927A2 (en) * 2000-06-30 2002-01-03 Epigenomics Ag Diagnosis of diseases associated with development by means of assessing their methylation status
WO2002040716A2 (en) * 2000-11-16 2002-05-23 Cemines, Llc Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes
US20040242510A1 (en) * 2001-10-05 2004-12-02 Markowitz Sanford D. Methods and compositions for detecting colon cancers
WO2005059172A2 (en) * 2003-12-11 2005-06-30 Epigenomics Ag Method and nucleic acids for the improved treatment of breast cell proliferative disorders

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ASATIANI EKATHERINE ET AL: "Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer.", CANCER RESEARCH. 15 FEB 2005, vol. 65, no. 4, 15 February 2005 (2005-02-15), pages 1164 - 1173, XP002403472, ISSN: 0008-5472 *
DATABASE NCBI NUCLEOTIDE 1 February 2002 (2002-02-01), XP002403740, Database accession no. AX344748 *
YAN P S ET AL: "CpG island arrays: an application toward deciphering epigenetic signatures of breast cancer", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 6, no. 4, April 2000 (2000-04-01), pages 1432 - 1438, XP002245955, ISSN: 1078-0432 *

Also Published As

Publication number Publication date
WO2007003397A2 (en) 2007-01-11

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