WO2004066183A3 - Microrna - Google Patents

Microrna Download PDF

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Publication number
WO2004066183A3
WO2004066183A3 PCT/IB2004/000620 IB2004000620W WO2004066183A3 WO 2004066183 A3 WO2004066183 A3 WO 2004066183A3 IB 2004000620 W IB2004000620 W IB 2004000620W WO 2004066183 A3 WO2004066183 A3 WO 2004066183A3
Authority
WO
WIPO (PCT)
Prior art keywords
microrna
molecules
mirna
targets
novel
Prior art date
Application number
PCT/IB2004/000620
Other languages
French (fr)
Other versions
WO2004066183A2 (en
Inventor
Stephen Cohen
Julius Brennecke
Robert B Russell
Alexander Stark
Original Assignee
European Molecular Biology Lab Embl
Stephen Cohen
Julius Brennecke
Robert B Russell
Alexander Stark
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0301459.4A external-priority patent/GB0301459D0/en
Priority claimed from GBGB0317991.8A external-priority patent/GB0317991D0/en
Application filed by European Molecular Biology Lab Embl, Stephen Cohen, Julius Brennecke, Robert B Russell, Alexander Stark filed Critical European Molecular Biology Lab Embl
Publication of WO2004066183A2 publication Critical patent/WO2004066183A2/en
Publication of WO2004066183A3 publication Critical patent/WO2004066183A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/10—Nucleic acid folding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/10—Production naturally occurring
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Abstract

The invention relates to computational methods of identifying novel microRNA (miRNA) molecules and novel targets for miRNA molecules and the microRNA molecules and targets identified by such methods.
PCT/IB2004/000620 2003-01-22 2004-01-22 Microrna WO2004066183A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0301459.4 2003-01-22
GBGB0301459.4A GB0301459D0 (en) 2003-01-22 2003-01-22 Microrna
GB0317991.8 2003-07-31
GBGB0317991.8A GB0317991D0 (en) 2003-07-31 2003-07-31 Microrna

Publications (2)

Publication Number Publication Date
WO2004066183A2 WO2004066183A2 (en) 2004-08-05
WO2004066183A3 true WO2004066183A3 (en) 2004-12-02

Family

ID=32773969

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/000620 WO2004066183A2 (en) 2003-01-22 2004-01-22 Microrna

Country Status (1)

Country Link
WO (1) WO2004066183A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946177B2 (en) 2004-11-12 2015-02-03 Mima Therapeutics, Inc Methods and compositions involving miRNA and miRNA inhibitor molecules

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2361984A1 (en) 2003-10-09 2011-08-31 E. I. du Pont de Nemours and Company Gene silencing by using modified micro-RNA molecules
EP2322650A1 (en) 2004-05-14 2011-05-18 Rosetta Genomics Ltd MicroRNAs and uses thereof
US7795419B2 (en) 2004-05-26 2010-09-14 Rosetta Genomics Ltd. Viral and viral associated miRNAs and uses thereof
EP2290071B1 (en) 2004-05-28 2014-12-31 Asuragen, Inc. Methods and compositions involving microRNA
BRPI0516874A (en) 2004-10-12 2008-09-23 Univ Rockefeller microornas
JP5956709B2 (en) 2005-05-27 2016-07-27 オスペダーレ サン ラファエレ エス．アール．エル Gene vector
CN101268194A (en) 2005-09-20 2008-09-17 巴斯福植物科学有限公司 Methods for controlling gene expression using ta-siRNA
US8014956B2 (en) 2005-12-30 2011-09-06 Industrial Technology Research Institute MicroRNA precursors
US8361714B2 (en) 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
DK2364362T3 (en) 2008-11-12 2016-01-25 Ospedale San Raffaele Srl Gene vector FOR INDUCTION OF IMMUNE TOLERANCE transgene
WO2012041959A1 (en) 2010-09-30 2012-04-05 University Of Zurich Treatment of b-cell lymphoma with microrna
WO2012106586A1 (en) 2011-02-03 2012-08-09 Mirna Therapeutics, Inc. Synthetic mimics of mir-124
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
WO2013189047A1 (en) * 2012-06-20 2013-12-27 南京大学 Plant microrna identification and application thereof
KR20160131072A (en) 2014-03-12 2016-11-15 더 유니버시티 오브 시드니 Rna production in higher plants
US20180010136A1 (en) * 2014-05-30 2018-01-11 John Francis Hunt, III Methods for Altering Polypeptide Expression
CN109859798B (en) * 2019-01-21 2023-06-23 桂林电子科技大学 Prediction method for interaction of sRNA and target mRNA in bacteria
CN117116361B (en) * 2023-10-25 2024-01-26 江西师范大学 12sRNA secondary structure visualization method based on fixed frame

Citations (2)

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WO2003065281A1 (en) * 2002-01-29 2003-08-07 Health Research, Inc. Statistical algorithms for folding and target accessibility prediction and design of nucleic acids
WO2004009779A2 (en) * 2002-07-19 2004-01-29 University Of South Carolina Compositions and methods for the modulation of gene expression in plants

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003065281A1 (en) * 2002-01-29 2003-08-07 Health Research, Inc. Statistical algorithms for folding and target accessibility prediction and design of nucleic acids
WO2004009779A2 (en) * 2002-07-19 2004-01-29 University Of South Carolina Compositions and methods for the modulation of gene expression in plants

Non-Patent Citations (18)

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Title
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BRENNECKE JULIUS ET AL: "bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila.", CELL. UNITED STATES 4 APR 2003, vol. 113, no. 1, 4 April 2003 (2003-04-04), pages 25 - 36, XP001181836, ISSN: 0092-8674 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946177B2 (en) 2004-11-12 2015-02-03 Mima Therapeutics, Inc Methods and compositions involving miRNA and miRNA inhibitor molecules

Also Published As

Publication number Publication date
WO2004066183A2 (en) 2004-08-05

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