ATE335512T1 - Verminderungsregulation der genexpression durch kolorektale verabreichung von synthetischen oligonukleotiden - Google Patents

Verminderungsregulation der genexpression durch kolorektale verabreichung von synthetischen oligonukleotiden

Info

Publication number
ATE335512T1
ATE335512T1 AT98911615T AT98911615T ATE335512T1 AT E335512 T1 ATE335512 T1 AT E335512T1 AT 98911615 T AT98911615 T AT 98911615T AT 98911615 T AT98911615 T AT 98911615T AT E335512 T1 ATE335512 T1 AT E335512T1
Authority
AT
Austria
Prior art keywords
gene expression
synthetic oligonucleotides
administration
reduced regulation
colorectal
Prior art date
Application number
AT98911615T
Other languages
English (en)
Inventor
Ruiwen Zhang
Sudhir Agrawal
Original Assignee
Idera Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idera Pharmaceuticals Inc filed Critical Idera Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE335512T1 publication Critical patent/ATE335512T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
AT98911615T 1997-03-12 1998-03-12 Verminderungsregulation der genexpression durch kolorektale verabreichung von synthetischen oligonukleotiden ATE335512T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4073897P 1997-03-12 1997-03-12
US84641797A 1997-04-30 1997-04-30

Publications (1)

Publication Number Publication Date
ATE335512T1 true ATE335512T1 (de) 2006-09-15

Family

ID=26717368

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98911615T ATE335512T1 (de) 1997-03-12 1998-03-12 Verminderungsregulation der genexpression durch kolorektale verabreichung von synthetischen oligonukleotiden

Country Status (7)

Country Link
EP (1) EP1007098B1 (de)
JP (1) JP2001527536A (de)
AT (1) ATE335512T1 (de)
AU (1) AU6553398A (de)
CA (1) CA2283684C (de)
DE (1) DE69835525T2 (de)
WO (1) WO1998040058A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1007657B1 (de) 1997-08-19 2006-02-08 Idera Pharmaceuticals, Inc. Hiv-spezifische oligonukleotide und verfahren zu deren verwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0677056T3 (da) * 1993-01-25 1996-08-05 Hybridon Inc Oligonukleotid-alkylphosphonater og -alkylphosphonothioater
US6348449B1 (en) * 1993-09-21 2002-02-19 The Trustees Of The University Of Pennsylvania Methods of inducing mucosal immunity
US5591721A (en) * 1994-10-25 1997-01-07 Hybridon, Inc. Method of down-regulating gene expression
JPH11510164A (ja) * 1995-07-26 1999-09-07 マキシム ファーマシューティカルズ ポリヌクレオチドの粘膜送達

Also Published As

Publication number Publication date
JP2001527536A (ja) 2001-12-25
AU6553398A (en) 1998-09-29
DE69835525D1 (de) 2006-09-21
EP1007098A2 (de) 2000-06-14
WO1998040058A3 (en) 1998-11-19
DE69835525T2 (de) 2007-03-08
CA2283684A1 (en) 1998-09-17
CA2283684C (en) 2010-06-08
WO1998040058A2 (en) 1998-09-17
EP1007098B1 (de) 2006-08-09

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