ATE320439T1 - Anti-(retro)virale konjugate von sacchariden und acetamidino- oder guanidinoverbindungen - Google Patents

Anti-(retro)virale konjugate von sacchariden und acetamidino- oder guanidinoverbindungen

Info

Publication number
ATE320439T1
ATE320439T1 AT99961263T AT99961263T ATE320439T1 AT E320439 T1 ATE320439 T1 AT E320439T1 AT 99961263 T AT99961263 T AT 99961263T AT 99961263 T AT99961263 T AT 99961263T AT E320439 T1 ATE320439 T1 AT E320439T1
Authority
AT
Austria
Prior art keywords
saccharide
aids
acetamidino
residue
conjugates
Prior art date
Application number
AT99961263T
Other languages
English (en)
Inventor
Aviva Lapidot
Alexander Litovchick
Artem Evdokimov
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE320439T1 publication Critical patent/ATE320439T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT99961263T 1998-12-28 1999-12-28 Anti-(retro)virale konjugate von sacchariden und acetamidino- oder guanidinoverbindungen ATE320439T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL12777398A IL127773A0 (en) 1998-12-28 1998-12-28 Saccharide conjugates and pharmaceutical compositions comprising them

Publications (1)

Publication Number Publication Date
ATE320439T1 true ATE320439T1 (de) 2006-04-15

Family

ID=11072308

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99961263T ATE320439T1 (de) 1998-12-28 1999-12-28 Anti-(retro)virale konjugate von sacchariden und acetamidino- oder guanidinoverbindungen

Country Status (9)

Country Link
US (1) US6642365B1 (de)
EP (1) EP1140958B1 (de)
JP (1) JP2003525859A (de)
AT (1) ATE320439T1 (de)
AU (1) AU1795600A (de)
DE (1) DE69930412T2 (de)
HK (1) HK1042904A1 (de)
IL (2) IL127773A0 (de)
WO (1) WO2000039139A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2829136B1 (fr) * 2001-08-29 2006-11-17 Aventis Pharma Sa Derives lipidiques d'aminoglycosides
AU2002359679B2 (en) * 2001-12-11 2009-01-08 Cellgate, Inc. Guanidinium transport reagents and conjugates
US20050085432A1 (en) * 2001-12-26 2005-04-21 Aviva Lapidot Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections
AU2002951247A0 (en) * 2002-09-06 2002-09-19 Alchemia Limited Compounds that interact with kinases
US7514404B2 (en) 2003-12-15 2009-04-07 University Of Medicine & Dentistry Of New Jersey PNA-neamine conjugates and methods for producing and using the same
CA2481491A1 (en) 2004-09-14 2006-03-14 Le Groupe Lysac Inc. Amidinated or guanidinated polysaccharides, their use as absorbents and a process for producing same
JP5256043B2 (ja) 2005-12-02 2013-08-07 アイシス ファーマシューティカルズ， インコーポレーテッド 複数の置換基を有する抗菌４，５−置換アミノグリコシドアナログ
FR2930942B1 (fr) * 2008-05-07 2011-03-04 Centre Nat Rech Scient Nouvelles utilisations de derives de d-mannopyranose activateurs de l'angiogenese
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
MX2012004036A (es) 2009-10-09 2012-06-27 Achaogen Inc Analogos de aminoglicosidos antibacterianos.
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
TW201304784A (zh) 2010-11-17 2013-02-01 Achaogen Inc 抗菌性胺基糖苷類似物
WO2018150196A1 (en) * 2017-02-17 2018-08-23 Oxford University Innovation Limited Cell penetrating peptides modified by glycosylation
EP3883943A4 (de) * 2018-11-22 2023-01-04 Technion Research & Development Foundation Limited Modifizierte aminoglycosidverbindungen und ihre verwendungen zur deaktivierung von bakteriellen ribosomen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0312222B1 (de) * 1987-10-14 1992-08-05 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Behandlung von Viruskrankheiten
WO1995000177A1 (en) * 1993-06-17 1995-01-05 Dextran Products Limited Pharmaceutical preparation and a method for inhibiting the replication of various viruses
US5593835A (en) * 1995-05-12 1997-01-14 President And Fellows Of Harvard College Methods and kits for RNA binding compounds

Also Published As

Publication number Publication date
IL127773A0 (en) 1999-10-28
IL143995A (en) 2006-12-31
JP2003525859A (ja) 2003-09-02
US6642365B1 (en) 2003-11-04
AU1795600A (en) 2000-07-31
HK1042904A1 (zh) 2002-08-30
WO2000039139A1 (en) 2000-07-06
EP1140958B1 (de) 2006-03-15
EP1140958A1 (de) 2001-10-10
DE69930412T2 (de) 2006-08-24
DE69930412D1 (de) 2006-05-11

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