ATE31537T1 - Peptidderivate mit polyzyklischer stickstoffstruktur, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen. - Google Patents
Peptidderivate mit polyzyklischer stickstoffstruktur, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.Info
- Publication number
- ATE31537T1 ATE31537T1 AT86400010T AT86400010T ATE31537T1 AT E31537 T1 ATE31537 T1 AT E31537T1 AT 86400010 T AT86400010 T AT 86400010T AT 86400010 T AT86400010 T AT 86400010T AT E31537 T1 ATE31537 T1 AT E31537T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- peptide derivatives
- optionally substituted
- Prior art date
Links
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- SLBZCKMOHSBDJK-UHFFFAOYSA-N [amino-[amino-(hydroxymethylsulfanyl)-sulfanylmethyl]sulfinyl-sulfanylmethyl]sulfanylmethanol Chemical compound OCSC(S)(N)S(=O)C(N)(S)SCO SLBZCKMOHSBDJK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8500140A FR2575753B1 (fr) | 1985-01-07 | 1985-01-07 | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP86400010A EP0190058B1 (fr) | 1985-01-07 | 1986-01-06 | Nouveaux dérivés peptidiques à structure polycyclique azotée, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE31537T1 true ATE31537T1 (de) | 1988-01-15 |
Family
ID=9315046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86400010T ATE31537T1 (de) | 1985-01-07 | 1986-01-06 | Peptidderivate mit polyzyklischer stickstoffstruktur, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen. |
Country Status (15)
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2610934B1 (fr) * | 1987-02-13 | 1989-05-05 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2616663B1 (fr) * | 1987-06-16 | 1989-08-18 | Adir | Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| US5648333A (en) * | 1988-11-24 | 1997-07-15 | Hoechst Aktiengesellschaft | Peptides having bradykinin antagonist action |
| IE63490B1 (en) * | 1988-11-24 | 1995-05-03 | Hoechst Ag | Peptides having bradykinin antagonist action |
| FR2649110B1 (fr) * | 1989-06-29 | 1994-10-21 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5028593A (en) * | 1989-08-15 | 1991-07-02 | Board Of Regents, The University Of Texas System | Tuftsin analogs |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| EP0454302A3 (en) * | 1990-03-30 | 1992-10-14 | Banyu Pharmaceutical Co., Ltd. | Tuftsin derivatives |
| FR2663336B1 (fr) * | 1990-06-18 | 1992-09-04 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5391705A (en) * | 1991-03-15 | 1995-02-21 | Merrell Dow Pharmaceuticals Inc. | Polyfluorinated tripeptide thrombin inhibitors |
| US6177405B1 (en) * | 1992-07-22 | 2001-01-23 | Kenji Nishioka | Cyclic analogs of tuftsin |
| US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
| AU708620B2 (en) * | 1995-03-29 | 1999-08-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6069232A (en) * | 1995-10-02 | 2000-05-30 | Hoechst Marion Roussel, Inc. | Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors |
| US5739354A (en) * | 1996-03-26 | 1998-04-14 | Hoechst Marion Roussel, Inc. | Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide |
| JP4080541B2 (ja) | 1996-10-18 | 2008-04-23 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼ、特にｃ型肝炎ウイルスｎｓ３プロテアーゼの阻害因子 |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| CA2449504A1 (en) | 2001-07-11 | 2003-01-23 | Vertex Pharmaceuticals Incorporated | Bridged bicyclic serine protease inhibitors |
| MXPA04005557A (es) * | 2002-03-01 | 2005-05-17 | Warner Lambert Co | Metodo para tratar la osteoartritis. |
| TWI359147B (en) | 2003-09-05 | 2012-03-01 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv n |
| US8076352B2 (en) * | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| BRPI0508814B8 (pt) * | 2004-03-15 | 2021-05-25 | Ptc Therapeutics Inc | derivados de carbolina, bem como uso dos mesmos e composição farmacêutica |
| US8076353B2 (en) * | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| US7767689B2 (en) * | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| EP1740173A4 (en) * | 2004-03-23 | 2009-05-27 | Genentech Inc | AZABICYCLOOCTAN IAP INHIBITORS |
| EP2065368A1 (en) | 2004-04-07 | 2009-06-03 | Novartis Ag | Inhibitors of IAP |
| WO2006014361A1 (en) * | 2004-07-02 | 2006-02-09 | Genentech, Inc. | Inhibitors of iap |
| WO2006069063A1 (en) * | 2004-12-20 | 2006-06-29 | Genentech, Inc. | Pyrrolidine inhibitors of iap |
| MX2008001528A (es) * | 2005-08-02 | 2008-04-04 | Vertex Pharma | Inhibidores de serina proteasas. |
| US7964624B1 (en) * | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| US8247557B2 (en) * | 2005-12-19 | 2012-08-21 | Genentech, Inc. | IAP inhibitors |
| JP5436864B2 (ja) | 2006-02-27 | 2014-03-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｖｘ−９５０を含む共結晶体およびそれを含む医薬組成物 |
| WO2007109080A2 (en) * | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
| PE20110220A1 (es) | 2006-08-02 | 2011-04-11 | Novartis Ag | DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS |
| MX2009002893A (es) | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
| RU2466131C2 (ru) * | 2006-12-19 | 2012-11-10 | Дженентек, Инк. | Имидазопиридиновые ингибиторы iap |
| EP2134717A2 (en) * | 2007-02-27 | 2009-12-23 | Vertex Pharmceuticals Incorporated | Inhibitors of serine proteases |
| PT2114924E (pt) * | 2007-02-27 | 2012-04-03 | Vertex Pharma | Co-cristais e composições farmacêuticas que compreendem os mesmos |
| PE20090211A1 (es) * | 2007-04-30 | 2009-04-02 | Genentech Inc | Inhibidores de las iap |
| EP2185546B1 (en) * | 2007-08-30 | 2011-10-26 | Vertex Pharmceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| NZ586650A (en) * | 2008-01-11 | 2012-11-30 | Genentech Inc | Inhibitors of iap |
| NZ590550A (en) | 2008-08-02 | 2013-05-31 | Genentech Inc | Inhibitors of Apoptosis (IAP) for treating cancer |
| NZ590500A (en) * | 2008-08-16 | 2012-06-29 | Genentech Inc | Azaindole inhibitors of iap |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| BR112014016548A8 (pt) | 2012-01-06 | 2017-07-04 | Board Of Regents Of The Univ Of Oklahoma | tensoativos baseados em sulfóxido |
| US9284294B2 (en) | 2012-02-09 | 2016-03-15 | Novus International, Inc. | Functionalized polymer compositions |
| EP2871973B1 (en) | 2012-07-12 | 2018-10-03 | Novus International Inc. | Matrix and layer compositions for protection of bioactives |
| CN108291055B (zh) | 2015-11-12 | 2021-07-06 | 诺华丝国际股份有限公司 | 作为溶剂的含硫化合物 |
| US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5647895B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1973-06-08 | 1981-11-12 | ||
| US4353823A (en) * | 1981-09-01 | 1982-10-12 | Chipens Gunar I | Synthetic analog of tuftisin |
-
1985
- 1985-01-07 FR FR8500140A patent/FR2575753B1/fr not_active Expired
-
1986
- 1986-01-06 CA CA000499067A patent/CA1270596A/fr not_active Expired - Lifetime
- 1986-01-06 EP EP86400010A patent/EP0190058B1/fr not_active Expired
- 1986-01-06 NZ NZ214722A patent/NZ214722A/xx unknown
- 1986-01-06 AT AT86400010T patent/ATE31537T1/de not_active IP Right Cessation
- 1986-01-06 IE IE2186A patent/IE58273B1/en not_active IP Right Cessation
- 1986-01-06 AU AU51854/86A patent/AU578781B2/en not_active Ceased
- 1986-01-06 PT PT81793A patent/PT81793B/pt not_active IP Right Cessation
- 1986-01-06 DE DE8686400010T patent/DE3660010D1/de not_active Expired
- 1986-01-06 JP JP61000483A patent/JPS61161298A/ja active Granted
- 1986-01-07 ES ES550716A patent/ES8707552A1/es not_active Expired
- 1986-01-07 OA OA58759A patent/OA08182A/xx unknown
- 1986-01-07 ZA ZA86105A patent/ZA86105B/xx unknown
- 1986-01-07 GR GR860023A patent/GR860023B/el unknown
- 1986-11-20 US US06/933,093 patent/US4720484A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT81793B (pt) | 1988-05-27 |
| DE3660010D1 (en) | 1988-02-04 |
| EP0190058B1 (fr) | 1987-12-23 |
| ES550716A0 (es) | 1987-08-01 |
| IE860021L (en) | 1986-07-07 |
| ZA86105B (en) | 1986-10-29 |
| GR860023B (en) | 1986-05-06 |
| EP0190058A1 (fr) | 1986-08-06 |
| AU578781B2 (en) | 1988-11-03 |
| NZ214722A (en) | 1988-09-29 |
| AU5185486A (en) | 1986-07-10 |
| JPS61161298A (ja) | 1986-07-21 |
| FR2575753A1 (fr) | 1986-07-11 |
| US4720484A (en) | 1988-01-19 |
| OA08182A (fr) | 1987-10-30 |
| IE58273B1 (en) | 1993-08-25 |
| FR2575753B1 (fr) | 1987-02-20 |
| PT81793A (fr) | 1986-02-01 |
| JPH0229080B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-06-27 |
| ES8707552A1 (es) | 1987-08-01 |
| CA1270596A (fr) | 1990-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |