ATE303176T1 - Rückkopplungsmechanismus zur stimulation tiefliegender gehirnbereiche - Google Patents

Rückkopplungsmechanismus zur stimulation tiefliegender gehirnbereiche

Info

Publication number
ATE303176T1
ATE303176T1 AT00939701T AT00939701T ATE303176T1 AT E303176 T1 ATE303176 T1 AT E303176T1 AT 00939701 T AT00939701 T AT 00939701T AT 00939701 T AT00939701 T AT 00939701T AT E303176 T1 ATE303176 T1 AT E303176T1
Authority
AT
Austria
Prior art keywords
patient
feedback mechanism
deep brain
brain areas
electrical stimulation
Prior art date
Application number
AT00939701T
Other languages
English (en)
Inventor
Nicholas D Schiff
Keith Purpura
Steven Kalik
Original Assignee
Cornell Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Res Foundation Inc filed Critical Cornell Res Foundation Inc
Application granted granted Critical
Publication of ATE303176T1 publication Critical patent/ATE303176T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071Pain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • A61B5/113Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb occurring during breathing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4041Evaluating nerves condition
    • A61B5/4052Evaluating nerves condition efferent nerves, i.e. nerves that relay impulses from the central nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/486Biofeedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Massaging Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Finger-Pressure Massage (AREA)
AT00939701T 1999-06-11 2000-06-09 Rückkopplungsmechanismus zur stimulation tiefliegender gehirnbereiche ATE303176T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33093599A 1999-06-11 1999-06-11
PCT/US2000/015798 WO2000076580A1 (en) 1999-06-11 2000-06-09 Feedback mechanism for deep brain stimulation

Publications (1)

Publication Number Publication Date
ATE303176T1 true ATE303176T1 (de) 2005-09-15

Family

ID=23291931

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05075990T ATE550988T1 (de) 1999-06-11 2000-06-09 Rückkopplungsmechanismus für die tiefenhirnstimulation
AT00939701T ATE303176T1 (de) 1999-06-11 2000-06-09 Rückkopplungsmechanismus zur stimulation tiefliegender gehirnbereiche

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05075990T ATE550988T1 (de) 1999-06-11 2000-06-09 Rückkopplungsmechanismus für die tiefenhirnstimulation

Country Status (6)

Country Link
EP (2) EP1559369B1 (de)
AT (2) ATE550988T1 (de)
AU (1) AU5475000A (de)
CA (1) CA2376533A1 (de)
DE (1) DE60022352T2 (de)
WO (1) WO2000076580A1 (de)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7640062B2 (en) 2000-05-08 2009-12-29 Brainsgate Ltd. Methods and systems for management of alzheimer's disease
US7120489B2 (en) 2000-05-08 2006-10-10 Brainsgate, Ltd. Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the BBB and cerebral blood flow
US7636597B2 (en) 2002-11-14 2009-12-22 Brainsgate, Ltd. Surgical tools and techniques for stimulation
US7684859B2 (en) 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
US7561919B2 (en) 2002-11-14 2009-07-14 Brainsgate Ltd. SPG stimulation via the greater palatine canal
US7107104B2 (en) 2003-05-30 2006-09-12 Medtronic, Inc. Implantable cortical neural lead and method
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US8055347B2 (en) * 2005-08-19 2011-11-08 Brainsgate Ltd. Stimulation for treating brain events and other conditions
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US7346382B2 (en) 2004-07-07 2008-03-18 The Cleveland Clinic Foundation Brain stimulation models, systems, devices, and methods
RU2285549C2 (ru) * 2004-11-22 2006-10-20 Александр Александрович Карасев Электронейроадаптивный стимулятор и выходной каскад электронейроадаптивного стимулятора
US8112154B2 (en) 2005-04-13 2012-02-07 The Cleveland Clinic Foundation Systems and methods for neuromodulation using pre-recorded waveforms
US9339650B2 (en) 2005-04-13 2016-05-17 The Cleveland Clinic Foundation Systems and methods for neuromodulation using pre-recorded waveforms
US8923977B2 (en) 2006-12-21 2014-12-30 Sapiens Steering Brain Stimulation B.V. Biomimetic neurostimulation device
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
US9220889B2 (en) 2008-02-11 2015-12-29 Intelect Medical, Inc. Directional electrode devices with locating features
US8019440B2 (en) 2008-02-12 2011-09-13 Intelect Medical, Inc. Directional lead assembly
US9272153B2 (en) 2008-05-15 2016-03-01 Boston Scientific Neuromodulation Corporation VOA generation system and method using a fiber specific analysis
JP5734295B2 (ja) 2009-08-27 2015-06-17 ザ クリーブランド クリニック ファウンデーション 組織活性の部位を推定するためのシステムおよび方法
WO2011068997A1 (en) 2009-12-02 2011-06-09 The Cleveland Clinic Foundation Reversing cognitive-motor impairments in patients having a neuro-degenerative disease using a computational modeling approach to deep brain stimulation programming
DE102010016461B4 (de) * 2010-04-15 2013-03-21 Forschungszentrum Jülich GmbH Vorrichtung zur Behandlung von Erkrankungen des Gehirns und/oder Rückenmarks mittels Neurofeedback
WO2011159688A2 (en) 2010-06-14 2011-12-22 Boston Scientific Neuromodulation Corporation Programming interface for spinal cord neuromodulation
US8565886B2 (en) 2010-11-10 2013-10-22 Medtronic, Inc. Arousal state modulation with electrical stimulation
JP2014518516A (ja) 2011-03-29 2014-07-31 ボストン サイエンティフィック ニューロモデュレイション コーポレイション アトラス位置合わせのためのシステムおよび方法
US9592389B2 (en) 2011-05-27 2017-03-14 Boston Scientific Neuromodulation Corporation Visualization of relevant stimulation leadwire electrodes relative to selected stimulation information
AU2012294364A1 (en) 2011-08-09 2014-03-20 Boston Scientific Neuromodulation Corporation Remote control for blind clinical trials of electrical stimulation
MX363322B (es) 2012-02-28 2019-03-20 Maria Soza Ana Metodos, aparatos y sistemas para el diagnostico y tratamiento de trastornos del estado de animo.
WO2013130421A1 (en) 2012-02-29 2013-09-06 The Cleveland Clinic Foundation System and method for neuromodulation using composite patterns of stimulation or waveforms
WO2014025624A1 (en) 2012-08-04 2014-02-13 Boston Scientific Neuromodulation Corporation Techniques and methods for storing and transferring registration, atlas, and lead information between medical devices
WO2014036079A2 (en) 2012-08-28 2014-03-06 Boston Scientific Neuromodulation Corporation Parameter visualization, selection, and annotation interface
US9792412B2 (en) 2012-11-01 2017-10-17 Boston Scientific Neuromodulation Corporation Systems and methods for VOA model generation and use
US10814131B2 (en) 2012-11-26 2020-10-27 Thync Global, Inc. Apparatuses and methods for neuromodulation
US10537703B2 (en) 2012-11-26 2020-01-21 Thync Global, Inc. Systems and methods for transdermal electrical stimulation to improve sleep
CN204147427U (zh) 2012-11-26 2015-02-11 塞恩克公司 可穿戴的皮肤电刺激设备
US9440070B2 (en) 2012-11-26 2016-09-13 Thyne Global, Inc. Wearable transdermal electrical stimulation devices and methods of using them
ES2696707T3 (es) 2013-06-29 2019-01-17 Cerevast Medical Inc Dispositivos de estimulación eléctrica transcutánea y métodos para modificar o inducir el estado cognitivo
US10293161B2 (en) 2013-06-29 2019-05-21 Thync Global, Inc. Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state
EP2878335B1 (de) 2013-11-10 2018-01-03 Brainsgate Ltd. Implantat und implantationssystem für nervenstimulator
CN106573138A (zh) 2014-02-27 2017-04-19 赛威医疗公司 用于神经刺激的用户控制的方法和装置
WO2015179281A2 (en) 2014-05-17 2015-11-26 Thync, Inc. Methods and apparatuses for the application of ensemble waveforms using transdermal neurostimulation
KR20170063440A (ko) 2014-05-25 2017-06-08 하이인 에쿼티 인베스트먼트 펀드 엘.피. 웨어러블 경피 신경자극기들
US9333334B2 (en) 2014-05-25 2016-05-10 Thync, Inc. Methods for attaching and wearing a neurostimulator
US9959388B2 (en) 2014-07-24 2018-05-01 Boston Scientific Neuromodulation Corporation Systems, devices, and methods for providing electrical stimulation therapy feedback
US10272247B2 (en) 2014-07-30 2019-04-30 Boston Scientific Neuromodulation Corporation Systems and methods for stimulation-related volume analysis, creation, and sharing with integrated surgical planning and stimulation programming
US10265528B2 (en) 2014-07-30 2019-04-23 Boston Scientific Neuromodulation Corporation Systems and methods for electrical stimulation-related patient population volume analysis and use
EP3204112A1 (de) 2014-10-07 2017-08-16 Boston Scientific Neuromodulation Corporation Systeme, vorrichtungen und verfahren zur elektrischen stimulation mittels rückkopplung zur einstellung von stimulationsparametern
US11534608B2 (en) 2015-01-04 2022-12-27 Ist, Llc Methods and apparatuses for transdermal stimulation of the outer ear
WO2016109851A1 (en) 2015-01-04 2016-07-07 Thync, Inc. Methods and apparatuses for transdermal stimulation of the outer ear
US10258788B2 (en) 2015-01-05 2019-04-16 Thync Global, Inc. Electrodes having surface exclusions
US10271907B2 (en) 2015-05-13 2019-04-30 Brainsgate Ltd. Implant and delivery system for neural stimulator
US10780283B2 (en) 2015-05-26 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
EP3268082B1 (de) 2015-05-26 2019-04-17 Boston Scientific Neuromodulation Corporation Systeme und verfahren zur analyse von elektrischer stimulation und auswahl oder manipulation von aktivierungsvolumina
EP3302682A1 (de) 2015-05-29 2018-04-11 Cerevast Medical Inc. Verfahren und vorrichtung zur transdermalen elektrischen stimulation
WO2016196635A2 (en) 2015-06-01 2016-12-08 Cerevast Medical Inc. Apparatuses and methods for neuromodulation
WO2017003946A1 (en) 2015-06-29 2017-01-05 Boston Scientific Neuromodulation Corporation Systems and methods for selecting stimulation parameters based on stimulation target region, effects, or side effects
WO2017003947A1 (en) 2015-06-29 2017-01-05 Boston Scientific Neuromodulation Corporation Systems and methods for selecting stimulation parameters by targeting and steering
US10071249B2 (en) 2015-10-09 2018-09-11 Boston Scientific Neuromodulation Corporation System and methods for clinical effects mapping for directional stimulation leads
WO2017106878A1 (en) 2015-12-18 2017-06-22 Thync Global, Inc. Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state
US9956405B2 (en) 2015-12-18 2018-05-01 Thyne Global, Inc. Transdermal electrical stimulation at the neck to induce neuromodulation
US10786674B2 (en) * 2016-03-08 2020-09-29 Medtronic, Inc. Medical therapy target definition
US10716942B2 (en) 2016-04-25 2020-07-21 Boston Scientific Neuromodulation Corporation System and methods for directional steering of electrical stimulation
US10646708B2 (en) 2016-05-20 2020-05-12 Thync Global, Inc. Transdermal electrical stimulation at the neck
CN109416937A (zh) 2016-06-24 2019-03-01 波士顿科学神经调制公司 用于临床效果的视觉分析的系统和方法
WO2018044881A1 (en) 2016-09-02 2018-03-08 Boston Scientific Neuromodulation Corporation Systems and methods for visualizing and directing stimulation of neural elements
US10780282B2 (en) 2016-09-20 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for steering electrical stimulation of patient tissue and determining stimulation parameters
CN109803719B (zh) 2016-10-14 2023-05-26 波士顿科学神经调制公司 用于闭环确定电模拟系统的刺激参数设置的系统和方法
ES2871008T3 (es) 2017-01-03 2021-10-28 Boston Scient Neuromodulation Corp Sistemas y procedimientos para seleccionar parámetros de estimulación compatibles con IRM
EP3519043B1 (de) 2017-01-10 2020-08-12 Boston Scientific Neuromodulation Corporation Systeme und verfahren zum erstellen von stimulationsprogrammen basierend auf benutzerdefinierten bereichen oder volumen
US10625082B2 (en) 2017-03-15 2020-04-21 Boston Scientific Neuromodulation Corporation Visualization of deep brain stimulation efficacy
WO2018187090A1 (en) 2017-04-03 2018-10-11 Boston Scientific Neuromodulation Corporation Systems and methods for estimating a volume of activation using a compressed database of threshold values
US10716505B2 (en) 2017-07-14 2020-07-21 Boston Scientific Neuromodulation Corporation Systems and methods for estimating clinical effects of electrical stimulation
WO2019036180A1 (en) 2017-08-15 2019-02-21 Boston Scientific Neuromodulation Corporation SYSTEMS AND METHODS FOR CONTROLLING ELECTRICAL STIMULATION USING MULTIPLE STIMULATION FIELDS
EP3784337B1 (de) 2018-04-24 2023-06-28 Thync Global, Inc. Vereinfachte und voreingestellte neuromodulatoren
US11298553B2 (en) 2018-04-27 2022-04-12 Boston Scientific Neuromodulation Corporation Multi-mode electrical stimulation systems and methods of making and using
EP3784332B1 (de) 2018-04-27 2023-04-26 Boston Scientific Neuromodulation Corporation Systeme zur visualisierung und programmierung der elektrischen stimulation
US12465718B2 (en) 2019-01-18 2025-11-11 Ist, Llc Methods and devices for modulation of integrated neural networks to influence composite sensory processes
WO2021067370A1 (en) 2019-09-30 2021-04-08 Thync Global, Inc. Neuromodulator apparatuses comprising led driver integrated circuits
WO2022232036A1 (en) 2021-04-27 2022-11-03 Boston Scientific Neuromodulation Corporation Systems and methods for automated programming of electrical stimulation
EP4313269B1 (de) 2021-06-15 2026-04-15 Boston Scientific Neuromodulation Corporation Verfahren und systeme zur schätzung der nervenaktivierung durch stimulation unter verwendung eines stimulationssystems
WO2023107457A2 (en) 2021-12-09 2023-06-15 Boston Scientific Neuromodulation Corparation Methods and systems for monitoring or assessing movement disorders or other physiological parameters using a stimulation system
WO2023107449A2 (en) 2021-12-10 2023-06-15 Boston Scientific Neuromodulation Corporation Systems and methods for generating and using response maps for electrical stimulation
WO2023167872A1 (en) 2022-03-02 2023-09-07 Boston Scientific Neuromodulation Corporation Systems and methods for monitoring stimulation drift in an electrical stimulation system
EP4669417A1 (de) * 2023-02-24 2025-12-31 Sony Group Corporation Elektronische vorrichtung und verfahren

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1390732A (en) * 1973-01-11 1975-04-16 Neuro Systems Inc Electrotherapy machines
JP3493196B2 (ja) * 1992-06-24 2004-02-03 サイベロニクス,インク. 神経刺激による神経精神障害の治療
DE69611031T2 (de) * 1996-03-19 2001-05-17 Balance International Inc., Boulder Verfahren und Vorrichtung für Gleichgewicht-Prothese
US5716377A (en) * 1996-04-25 1998-02-10 Medtronic, Inc. Method of treating movement disorders by brain stimulation
US6104956A (en) * 1996-05-31 2000-08-15 Board Of Trustees Of Southern Illinois University Methods of treating traumatic brain injury by vagus nerve stimulation
US5938688A (en) 1997-10-22 1999-08-17 Cornell Research Foundation, Inc. Deep brain stimulation method

Also Published As

Publication number Publication date
EP1559369B1 (de) 2012-03-28
EP1191972A1 (de) 2002-04-03
EP1191972B1 (de) 2005-08-31
EP1559369A1 (de) 2005-08-03
WO2000076580A1 (en) 2000-12-21
DE60022352D1 (de) 2005-10-06
AU5475000A (en) 2001-01-02
DE60022352T2 (de) 2006-06-14
ATE550988T1 (de) 2012-04-15
CA2376533A1 (en) 2000-12-21

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