ATE291588T1 - Endothel-spezifischer expression unter einfluss von epcr kontrollelementen - Google Patents

Endothel-spezifischer expression unter einfluss von epcr kontrollelementen

Info

Publication number
ATE291588T1
ATE291588T1 AT97948205T AT97948205T ATE291588T1 AT E291588 T1 ATE291588 T1 AT E291588T1 AT 97948205 T AT97948205 T AT 97948205T AT 97948205 T AT97948205 T AT 97948205T AT E291588 T1 ATE291588 T1 AT E291588T1
Authority
AT
Austria
Prior art keywords
seq
endothelial cells
epcr
promoter
nucleotides
Prior art date
Application number
AT97948205T
Other languages
English (en)
Inventor
Charles T Esmon
Jian-Ming Gu
Original Assignee
Oklahoma Med Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found filed Critical Oklahoma Med Res Found
Application granted granted Critical
Publication of ATE291588T1 publication Critical patent/ATE291588T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AT97948205T 1996-11-08 1997-11-07 Endothel-spezifischer expression unter einfluss von epcr kontrollelementen ATE291588T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3071896P 1996-11-08 1996-11-08
US5453397P 1997-08-04 1997-08-04
PCT/US1997/020364 WO1998020041A1 (en) 1996-11-08 1997-11-07 Endothelium specific expression regulated by epcr control elements

Publications (1)

Publication Number Publication Date
ATE291588T1 true ATE291588T1 (de) 2005-04-15

Family

ID=26706383

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97948205T ATE291588T1 (de) 1996-11-08 1997-11-07 Endothel-spezifischer expression unter einfluss von epcr kontrollelementen

Country Status (8)

Country Link
US (1) US6200751B1 (de)
EP (1) EP0937104B1 (de)
JP (1) JP2001503273A (de)
AT (1) ATE291588T1 (de)
AU (1) AU719629B2 (de)
CA (1) CA2270160A1 (de)
DE (1) DE69732847T2 (de)
WO (1) WO1998020041A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5695993A (en) 1994-08-12 1997-12-09 Oklahoma Medical Research Foundation Cloning and regulation of an endothelial cell protein C/activated protein C receptor
KR20010085313A (ko) * 1998-07-28 2001-09-07 나우톤 질 케이. 유전자조작된 세포와 조직
US6953568B1 (en) * 1998-08-25 2005-10-11 Oklahoma Medical Research Foundation Targeting of molecules to large vessel endothelium using EPCR
IL142680A0 (en) * 1998-10-19 2002-03-10 Powderject Vaccines Inc Minimal promoters and uses thereof
US8071740B2 (en) 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US20070286845A1 (en) * 2000-11-17 2007-12-13 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US8039261B2 (en) * 2000-11-17 2011-10-18 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
AU2003222427B8 (en) 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
US20100282634A1 (en) * 2000-11-17 2010-11-11 Dror Harats Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
EP2277887A3 (de) * 2001-10-19 2011-02-16 Vascular Biogenics Ltd. Polynukleotidkonstrukte, pharmazeutische Zusammensetzungen und Verfahren zur gezielten Abwärtsregulation der Angiogenese und Therapie gegen Krebs
US20070142272A1 (en) * 2003-01-24 2007-06-21 Zlokovic Berislav V Neuroprotective activity of activated protein c independent of its anticoagulant activity
WO2006014839A2 (en) * 2004-07-23 2006-02-09 The University Of Rochester Activated protein c inhibits undesirable effects of plasminogen activator in the brain
EP2951306A4 (de) 2013-01-30 2016-07-27 Univ Nebraska Zusammensetzungen und verfahren zur behandlung von komplikationen in zusammenhang mit diabetes
CN109897108B (zh) * 2019-03-11 2021-04-02 上海恒赛生物科技有限公司 抗人内皮蛋白c受体的羊驼单域抗体及应用
CN114457003A (zh) 2020-11-10 2022-05-10 维思尔治疗有限公司 预调节血管细胞用于转导的方法、转导方法和保存转导的细胞的方法

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Publication number Priority date Publication date Assignee Title
US3625214A (en) 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US4244946A (en) 1979-06-11 1981-01-13 The Salk Institute For Biological Studies Water-soluble peptides affecting gonadal function
US4305872A (en) 1979-10-19 1981-12-15 Kenneth Wingrove Polypeptide derivatives
US4316891A (en) 1980-06-14 1982-02-23 The Salk Institute For Biological Studies Extended N-terminal somatostatin
US4792525A (en) 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4906474A (en) 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4629784A (en) 1983-08-16 1986-12-16 The University Of Georgia Research Foundation, Inc. Synthesis of cyclopropane amino acids
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
IL79289A (en) 1985-07-05 1992-01-15 Whitehead Biomedical Inst Introduction and expression of foreign genetic material into keratinocytes using a recombinant retrovirus
US4789734A (en) 1985-08-06 1988-12-06 La Jolla Cancer Research Foundation Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
NL8720442A (nl) 1986-08-18 1989-04-03 Clinical Technologies Ass Afgeefsystemen voor farmacologische agentia.
US5009889A (en) 1987-12-31 1991-04-23 Oklahoma Medical Research Foundation Treatment of dysfunctional vascular endothelium using activated protein C
US5298422A (en) 1991-11-06 1994-03-29 Baylor College Of Medicine Myogenic vector systems
US5466596A (en) 1992-08-25 1995-11-14 Mount Sinai Hospital Corporation Tissue specific transcriptional regulatory element
US5695993A (en) * 1994-08-12 1997-12-09 Oklahoma Medical Research Foundation Cloning and regulation of an endothelial cell protein C/activated protein C receptor

Also Published As

Publication number Publication date
DE69732847D1 (de) 2005-04-28
JP2001503273A (ja) 2001-03-13
US6200751B1 (en) 2001-03-13
EP0937104B1 (de) 2005-03-23
CA2270160A1 (en) 1998-05-14
WO1998020041A1 (en) 1998-05-14
DE69732847T2 (de) 2006-04-13
AU719629B2 (en) 2000-05-11
EP0937104A1 (de) 1999-08-25
AU5431798A (en) 1998-05-29

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