ATE289507T1 - Rar-antagonisten zur verhütung für männer - Google Patents
Rar-antagonisten zur verhütung für männerInfo
- Publication number
- ATE289507T1 ATE289507T1 AT99948451T AT99948451T ATE289507T1 AT E289507 T1 ATE289507 T1 AT E289507T1 AT 99948451 T AT99948451 T AT 99948451T AT 99948451 T AT99948451 T AT 99948451T AT E289507 T1 ATE289507 T1 AT E289507T1
- Authority
- AT
- Austria
- Prior art keywords
- contraception
- men
- rar antagonists
- methods
- rar
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000021595 spermatogenesis Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10350798P | 1998-10-08 | 1998-10-08 | |
| PCT/US1999/022222 WO2000019990A2 (en) | 1998-10-08 | 1999-09-24 | Rar antagonists as male anti-fertility agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE289507T1 true ATE289507T1 (de) | 2005-03-15 |
Family
ID=22295572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99948451T ATE289507T1 (de) | 1998-10-08 | 1999-09-24 | Rar-antagonisten zur verhütung für männer |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1119350B1 (de) |
| JP (1) | JP2002526405A (de) |
| AT (1) | ATE289507T1 (de) |
| AU (1) | AU757448B2 (de) |
| CA (1) | CA2346687A1 (de) |
| DE (1) | DE69923854T2 (de) |
| WO (1) | WO2000019990A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020193403A1 (en) * | 2001-05-03 | 2002-12-19 | Allergan Sales, Inc. | Methods of treating hyperlipidemia |
| WO2008137081A1 (en) * | 2007-05-02 | 2008-11-13 | The Trustees Of Columbia University In The City Of New York | Substituted ( 5, 6 ) -dihydronaphraalenyl compounds as reversible male contraceptives |
| US7858666B2 (en) | 2007-06-08 | 2010-12-28 | Mannkind Corporation | IRE-1α inhibitors |
| CN107176945B (zh) * | 2016-03-11 | 2021-06-08 | 中国科学院上海有机化学研究所 | 一种视黄酸类化合物、其制备方法、中间体及应用 |
| EP4077300A1 (de) * | 2019-12-19 | 2022-10-26 | Orphagen Pharmaceuticals, Inc. | Rar-alpha-verbindungen für entzündliche erkrankungen und männliche kontrazeption |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2138000A1 (en) * | 1994-01-03 | 1995-07-04 | John E. Starrett, Jr. | Retinoid-like compounds |
| US5776699A (en) * | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
| US5958954A (en) * | 1995-09-01 | 1999-09-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US5877207A (en) * | 1996-03-11 | 1999-03-02 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US5728846A (en) * | 1996-12-12 | 1998-03-17 | Allergan | Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives |
| US5919970A (en) * | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
-
1999
- 1999-09-24 CA CA002346687A patent/CA2346687A1/en not_active Abandoned
- 1999-09-24 WO PCT/US1999/022222 patent/WO2000019990A2/en active IP Right Grant
- 1999-09-24 AU AU61623/99A patent/AU757448B2/en not_active Ceased
- 1999-09-24 DE DE69923854T patent/DE69923854T2/de not_active Expired - Fee Related
- 1999-09-24 EP EP99948451A patent/EP1119350B1/de not_active Expired - Lifetime
- 1999-09-24 JP JP2000573351A patent/JP2002526405A/ja active Pending
- 1999-09-24 AT AT99948451T patent/ATE289507T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1119350A2 (de) | 2001-08-01 |
| EP1119350B1 (de) | 2005-02-23 |
| WO2000019990A3 (en) | 2000-07-20 |
| DE69923854D1 (de) | 2005-03-31 |
| DE69923854T2 (de) | 2006-01-12 |
| JP2002526405A (ja) | 2002-08-20 |
| AU6162399A (en) | 2000-04-26 |
| AU757448B2 (en) | 2003-02-20 |
| WO2000019990A2 (en) | 2000-04-13 |
| CA2346687A1 (en) | 2000-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |