ATE288754T1 - Neue salze und kristalline formen von (2r)-anti-5-3-(4-(10,11-difluoromethanodibenzos ber-5- yl)piperazin-1-yl)-2-hydroxypropoxy quinolin - Google Patents
Neue salze und kristalline formen von (2r)-anti-5-3-(4-(10,11-difluoromethanodibenzos ber-5- yl)piperazin-1-yl)-2-hydroxypropoxy quinolinInfo
- Publication number
- ATE288754T1 ATE288754T1 AT02723495T AT02723495T ATE288754T1 AT E288754 T1 ATE288754 T1 AT E288754T1 AT 02723495 T AT02723495 T AT 02723495T AT 02723495 T AT02723495 T AT 02723495T AT E288754 T1 ATE288754 T1 AT E288754T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxypropoxy
- quinoline
- difluoromethanodibenzos
- ber
- piperazine
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28655601P | 2001-04-25 | 2001-04-25 | |
| US31881501P | 2001-09-13 | 2001-09-13 | |
| PCT/US2002/008256 WO2002087581A1 (en) | 2001-04-25 | 2002-04-12 | Novel salt and crystalline forms of (2r)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy}quinoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288754T1 true ATE288754T1 (de) | 2005-02-15 |
Family
ID=26963904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02723495T ATE288754T1 (de) | 2001-04-25 | 2002-04-12 | Neue salze und kristalline formen von (2r)-anti-5-3-(4-(10,11-difluoromethanodibenzos ber-5- yl)piperazin-1-yl)-2-hydroxypropoxy quinolin |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7282585B2 (de) |
| EP (1) | EP1387683B1 (de) |
| JP (1) | JP2004527552A (de) |
| AT (1) | ATE288754T1 (de) |
| CA (1) | CA2442608A1 (de) |
| DE (1) | DE60202944T2 (de) |
| ES (1) | ES2236506T3 (de) |
| PT (1) | PT1387683E (de) |
| WO (1) | WO2002087581A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0806434D0 (en) | 2008-04-09 | 2008-05-14 | Zephyros Inc | Improvements in or relating to structural adhesives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643909A (en) | 1993-04-19 | 1997-07-01 | Syntex (U.S.A.) Inc. | 10,11-Methanodibenzosuberane derivatives |
| ATE277922T1 (de) * | 1999-06-03 | 2004-10-15 | Lilly Co Eli | Verfahren zur herstellung von 10, 11methanodibenzosuberanderivaten |
| TWI267511B (en) * | 1999-06-03 | 2006-12-01 | Lilly Co Eli | Process for preparing 10,11-methanobenzosuberane derivatives |
-
2002
- 2002-04-12 PT PT02723495T patent/PT1387683E/pt unknown
- 2002-04-12 AT AT02723495T patent/ATE288754T1/de not_active IP Right Cessation
- 2002-04-12 WO PCT/US2002/008256 patent/WO2002087581A1/en not_active Ceased
- 2002-04-12 CA CA002442608A patent/CA2442608A1/en not_active Abandoned
- 2002-04-12 US US10/471,443 patent/US7282585B2/en not_active Expired - Fee Related
- 2002-04-12 JP JP2002584926A patent/JP2004527552A/ja active Pending
- 2002-04-12 DE DE60202944T patent/DE60202944T2/de not_active Expired - Fee Related
- 2002-04-12 ES ES02723495T patent/ES2236506T3/es not_active Expired - Lifetime
- 2002-04-12 EP EP02723495A patent/EP1387683B1/de not_active Expired - Lifetime
-
2007
- 2007-05-24 US US11/753,526 patent/US7582762B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1387683B1 (de) | 2005-02-09 |
| US20070244124A1 (en) | 2007-10-18 |
| US7582762B2 (en) | 2009-09-01 |
| JP2004527552A (ja) | 2004-09-09 |
| US7282585B2 (en) | 2007-10-16 |
| EP1387683A1 (de) | 2004-02-11 |
| WO2002087581A1 (en) | 2002-11-07 |
| ES2236506T3 (es) | 2005-07-16 |
| DE60202944T2 (de) | 2006-03-23 |
| DE60202944D1 (de) | 2005-03-17 |
| CA2442608A1 (en) | 2002-11-07 |
| US20040097519A1 (en) | 2004-05-20 |
| PT1387683E (pt) | 2005-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1387683 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |