ATE273993T1 - Verfahren zur kupplung in lösung zwischen einem peptid und einer lipophilen verbindung, und verwendungen davon - Google Patents
Verfahren zur kupplung in lösung zwischen einem peptid und einer lipophilen verbindung, und verwendungen davonInfo
- Publication number
- ATE273993T1 ATE273993T1 AT01967454T AT01967454T ATE273993T1 AT E273993 T1 ATE273993 T1 AT E273993T1 AT 01967454 T AT01967454 T AT 01967454T AT 01967454 T AT01967454 T AT 01967454T AT E273993 T1 ATE273993 T1 AT E273993T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide
- lipophilic
- lipophilic compound
- solution coupling
- lipopeptides
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 230000008878 coupling Effects 0.000 title abstract 2
- 238000010168 coupling process Methods 0.000 title abstract 2
- 238000005859 coupling reaction Methods 0.000 title abstract 2
- 150000002634 lipophilic molecules Chemical class 0.000 title 1
- 239000013598 vector Substances 0.000 abstract 3
- 108010028921 Lipopeptides Proteins 0.000 abstract 2
- 108090000189 Neuropeptides Proteins 0.000 abstract 1
- 102000003797 Neuropeptides Human genes 0.000 abstract 1
- 230000004888 barrier function Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0011451A FR2813794B1 (fr) | 2000-09-08 | 2000-09-08 | Procede de couplage, en solution, entre un peptide et un vecteur lipophile et ses applications |
| PCT/FR2001/002787 WO2002020558A2 (fr) | 2000-09-08 | 2001-09-07 | Procede de couplage, en solution, entre un peptide et un vecteur lipophile et ses applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE273993T1 true ATE273993T1 (de) | 2004-09-15 |
Family
ID=8854092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01967454T ATE273993T1 (de) | 2000-09-08 | 2001-09-07 | Verfahren zur kupplung in lösung zwischen einem peptid und einer lipophilen verbindung, und verwendungen davon |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7390875B2 (de) |
| EP (1) | EP1315739B1 (de) |
| JP (1) | JP5072164B2 (de) |
| AT (1) | ATE273993T1 (de) |
| AU (2) | AU8783201A (de) |
| CA (1) | CA2421791C (de) |
| DE (1) | DE60105037T2 (de) |
| FR (1) | FR2813794B1 (de) |
| WO (1) | WO2002020558A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6966113B2 (en) | 2001-07-23 | 2005-11-22 | Repetto Llc | Utility knife |
| FR2837104B1 (fr) * | 2002-03-14 | 2004-08-06 | Dev Des Antigenes Combinatoire | Utilisation de melange de lipopeptides pour la fabrication de vaccins |
| US7919653B2 (en) | 2002-07-30 | 2011-04-05 | Reverse Proteomics Research Institute Co., Ltd. | Method of inhibiting nonspecific interaction between molecules on solid phase support |
| WO2005046729A2 (en) * | 2003-11-12 | 2005-05-26 | Txcell | Use of lipopeptides for activating t lymphocytes through the skin |
| JP2012509272A (ja) * | 2008-11-17 | 2012-04-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | 核酸送達系のための放出性カチオン脂質 |
| US8968740B2 (en) | 2009-11-13 | 2015-03-03 | Dana-Farber Cancer Institute, Inc. | Compositions, kits, and methods for the diagnosis, prognosis, monitoring, treatment and modulation of post-transplant lymphoproliferative disorders and hypoxia associated angiogenesis disorders using galectin-1 |
| EP2343081A1 (de) * | 2009-12-31 | 2011-07-13 | Rijksuniversiteit Groningen | Interferon-Analoga |
| CN104837860A (zh) * | 2012-09-07 | 2015-08-12 | 新加坡科技研究局 | 肽及其用途 |
| WO2015081290A1 (en) | 2013-11-27 | 2015-06-04 | Inis Biotech Llc | Methods for modulating angiogenesis of cancers refractory to anti-vegf treatment |
| ES2928207T5 (en) * | 2018-04-10 | 2026-02-16 | Sanofi Aventis Deutschland | Lixisenatide synthesis with capping |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4687783A (en) * | 1983-03-01 | 1987-08-18 | Hoerrmann Wilhelm | Fatty aldehydes and acids in the treatment of neurological and dermatological diseases |
| FR2797632B1 (fr) * | 1999-08-19 | 2003-01-24 | Dutel Sa | Fonctionnalisation d'un peptide par un groupement alpha- hydrazinoacetique |
-
2000
- 2000-09-08 FR FR0011451A patent/FR2813794B1/fr not_active Expired - Fee Related
-
2001
- 2001-09-07 AU AU8783201A patent/AU8783201A/xx active Pending
- 2001-09-07 DE DE60105037T patent/DE60105037T2/de not_active Expired - Lifetime
- 2001-09-07 US US10/380,094 patent/US7390875B2/en not_active Expired - Fee Related
- 2001-09-07 WO PCT/FR2001/002787 patent/WO2002020558A2/fr not_active Ceased
- 2001-09-07 EP EP01967454A patent/EP1315739B1/de not_active Expired - Lifetime
- 2001-09-07 AU AU2001287832A patent/AU2001287832B2/en not_active Ceased
- 2001-09-07 JP JP2002525178A patent/JP5072164B2/ja not_active Expired - Fee Related
- 2001-09-07 CA CA2421791A patent/CA2421791C/fr not_active Expired - Fee Related
- 2001-09-07 AT AT01967454T patent/ATE273993T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001287832C1 (en) | 2002-03-22 |
| AU2001287832B2 (en) | 2007-05-24 |
| EP1315739B1 (de) | 2004-08-18 |
| JP5072164B2 (ja) | 2012-11-14 |
| EP1315739A2 (de) | 2003-06-04 |
| CA2421791C (fr) | 2011-11-15 |
| WO2002020558A2 (fr) | 2002-03-14 |
| CA2421791A1 (fr) | 2002-03-14 |
| WO2002020558A3 (fr) | 2003-01-09 |
| DE60105037D1 (de) | 2004-09-23 |
| FR2813794A1 (fr) | 2002-03-15 |
| FR2813794B1 (fr) | 2003-01-24 |
| US20040092015A1 (en) | 2004-05-13 |
| AU8783201A (en) | 2002-03-22 |
| US7390875B2 (en) | 2008-06-24 |
| JP2004510709A (ja) | 2004-04-08 |
| DE60105037T2 (de) | 2005-06-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60105037D1 (de) | Verfahren zur kupplung in lösung zwischen einem peptid und einer lipophilen verbindung, und verwendungen davon | |
| WO2005049091A3 (en) | Antibody-targeted nanoparticulate active agent delivery | |
| WO2005055945A3 (en) | Mucoadhesive drug delivery devices and methods of making and using thereof | |
| WO2003059251A3 (en) | Antibody targeting compounds | |
| EP1490483A4 (de) | In-vivo-einbau von nicht in der natur vorkommenden aminosäuren | |
| CY1106682T1 (el) | Ενωση λακταμης | |
| WO2002062844A3 (en) | Long lasting growth hormone releasing factor derivatives | |
| MXPA03007942A (es) | Preparaciones de insulina exentas de zinc y con bajo contenido de zinc, que tienen una estabilidad mejorada. | |
| WO2003011878A3 (en) | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity | |
| ATE383375T1 (de) | Wti-modifiziertes peptid | |
| WO2002028408A3 (en) | Compositions and methods for the transport of biologically active agents across cellular barriers | |
| WO2004113493A3 (en) | Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site | |
| WO2001047959A3 (en) | Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof | |
| WO2004019861A3 (en) | Stable ph optimized formulation of a modified antibody | |
| AU2002217010A1 (en) | Peptides, the production and use thereof for binding immunoglobulins | |
| MXPA03007904A (es) | Composiciones pesticidas que contienen acido oxalico. | |
| WO2020220044A3 (en) | Self-assembling protein nanocage decorated with antibodies (sapna) and parts thereof | |
| WO2003007689A3 (en) | Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids | |
| EP0987552A3 (de) | Diarylsulphonylharnstoff-Bindungsproteine | |
| WO2005007675A3 (en) | TRIAZOLE ϵ-AMINO ACIDS | |
| PT1259363E (pt) | Corpo formado por material inicialmente pastoso curado e incluindo um percurso electricamente condutor e um metodo de fabrico de um tal corpo | |
| WO2002062304A3 (de) | Kosmetische und/oder pharmazeutische mittel acylierte aminosäure und proteinkondensat enthaltend. | |
| WO2001058470A3 (en) | Methods for enhancing the bioavailability of a drug | |
| WO2003026700A3 (fr) | Compositions pour la vectorisation d'anticorps a travers la barriere hematoencephalique et leur utilisation pour le diagnostic ou le traitement des maladies du systeme nerveux central | |
| SG142165A1 (en) | Biologically active peptides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |