ATE264618T1 - Behandlung von durch vielfach ungesättigten lipid-metaboliten vermittelten lungenerkrankungen und tests für epoxidhydrolase-inhibitoren - Google Patents

Behandlung von durch vielfach ungesättigten lipid-metaboliten vermittelten lungenerkrankungen und tests für epoxidhydrolase-inhibitoren

Info

Publication number
ATE264618T1
ATE264618T1 AT97938335T AT97938335T ATE264618T1 AT E264618 T1 ATE264618 T1 AT E264618T1 AT 97938335 T AT97938335 T AT 97938335T AT 97938335 T AT97938335 T AT 97938335T AT E264618 T1 ATE264618 T1 AT E264618T1
Authority
AT
Austria
Prior art keywords
testing
treatment
lung disease
disease mediated
hydrolase inhibitors
Prior art date
Application number
AT97938335T
Other languages
English (en)
Inventor
Bruce D Hammock
Mehran F Moghaddam
Jeffrey M Cheek
Babak Borhan
James Fergusson
David F Grant
Jessica F Greene
Kazu Matoba
Jiang Zheng
Marlene F Sisemore
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE264618T1 publication Critical patent/ATE264618T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT97938335T 1996-08-13 1997-08-13 Behandlung von durch vielfach ungesättigten lipid-metaboliten vermittelten lungenerkrankungen und tests für epoxidhydrolase-inhibitoren ATE264618T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2339796P 1996-08-13 1996-08-13
US08/909,523 US5955496A (en) 1996-08-13 1997-08-12 Dihydroxy-oxy-eicosadienoates
PCT/US1997/014385 WO1998006261A1 (en) 1996-08-13 1997-08-13 Methods of treating pulmonary diseases mediated by polyunsaturated lipid metabolites and assays for epoxide hydrolase inhibitors

Publications (1)

Publication Number Publication Date
ATE264618T1 true ATE264618T1 (de) 2004-05-15

Family

ID=26697082

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97938335T ATE264618T1 (de) 1996-08-13 1997-08-13 Behandlung von durch vielfach ungesättigten lipid-metaboliten vermittelten lungenerkrankungen und tests für epoxidhydrolase-inhibitoren

Country Status (8)

Country Link
US (1) US5955496A (de)
EP (1) EP0926951B1 (de)
AT (1) ATE264618T1 (de)
AU (1) AU4069297A (de)
CA (1) CA2262525C (de)
DE (1) DE69728776T2 (de)
ES (1) ES2221064T3 (de)
WO (1) WO1998006261A1 (de)

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US6150415A (en) * 1996-08-13 2000-11-21 The Regents Of The University Of California Epoxide hydrolase complexes and methods therewith
US8815951B2 (en) * 1996-08-13 2014-08-26 The Regents Of The University Of California Inhibitors of epoxide hydrolases for the treatment of inflammation
US6693130B2 (en) * 1999-02-18 2004-02-17 Regents Of The University Of California Inhibitors of epoxide hydrolases for the treatment of hypertension
US6531506B1 (en) * 1996-08-13 2003-03-11 Regents Of The University Of California Inhibitors of epoxide hydrolases for the treatment of hypertension
US6174695B1 (en) * 1997-08-12 2001-01-16 The Regents Of The University Of California Epoxide hydrolase inhibitor methods
DE19847778A1 (de) * 1998-10-16 2000-04-20 Basf Ag Verfahren zur Herstellung von substituierten Dibenzoylmethanverbindungen
WO2000023060A2 (en) * 1998-10-20 2000-04-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method of treating immunological disorders mediated by t-lymphocytes
US6916843B1 (en) * 1999-08-11 2005-07-12 The United States Of America As Represented By The Department Of Health And Human Services Anti-inflammatory actions of cytochrome P450 expoxygenase-derived eicosanoids
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
US6794158B2 (en) * 2001-04-09 2004-09-21 Boehringer Ingelheim Pharmaceuticals, Inc. Fluorescence polarization assay
US6943001B2 (en) * 2001-08-03 2005-09-13 Diversa Corporation Epoxide hydrolases, nucleic acids encoding them and methods for making and using them
WO2003012126A2 (en) * 2001-08-03 2003-02-13 Diversa Corporation Epoxide hydrolases, nucleic acids encoding them and methods for making and using them
US20030139469A1 (en) * 2002-01-23 2003-07-24 The Regents Of The University Of California Use of inhibitors of soluble epoxide hydrolase to inhibit vascular smooth muscle cell proliferation
EP1608319A4 (de) 2003-04-03 2007-02-28 Univ California Verbesserte hemmer für lösliche epoxidhydrolase
JP2007532484A (ja) 2004-03-16 2007-11-15 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 可溶性エポキシド加水分解酵素の阻害剤およびエポキシエイコサノイドを用いて腎症を緩和する方法
US20050222252A1 (en) * 2004-03-31 2005-10-06 The Regents Of The University Of California Use of cis-Epoxyeicosantrienoic acids and inhibitors of soluble epoxide hydrolase to reduce pulmonary infiltration by neutrophils
CA2584342C (en) 2004-10-20 2013-04-30 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase
US7893106B2 (en) * 2004-11-19 2011-02-22 Martek Biosciences, Corporation Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same
US7884131B2 (en) * 2004-11-19 2011-02-08 Martek Biosciences, Corporation Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
US20090318394A1 (en) * 2004-11-19 2009-12-24 Julie Nauroth Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same
US20060293292A1 (en) * 2005-05-06 2006-12-28 Boehringer Ingelheim International Gmbh METHODS OF USING ACYL HYDRAZONES AS sEH INHIBITORS
US20060276515A1 (en) * 2005-05-06 2006-12-07 Cywin Charles L Soluble Epoxide Hydrolase Inhibitors and Methods of Using Same
WO2006133257A2 (en) * 2005-06-06 2006-12-14 The Regents Of The University Of California Use of cis-epoxyeicosatrienoic acids and inhibitors of soluble epoxide hydrolase to reduce cardiomyopathy
CA2619768A1 (en) * 2005-08-19 2007-02-22 The Regents Of The University Of California Use of seh inhibitors as analgesics
CA2622754A1 (en) * 2005-10-07 2007-04-19 Boehringer Ingelheim International Gmbh N-substituted pyridinone or pyrimidinone compounds useful as soluble epoxide hydrolase inhibitors
WO2007090162A2 (en) * 2006-01-31 2007-08-09 Martek Biosciences Corporation OXYLIPINS FROM STEARIDONIC ACID AND γ-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME
EP2124928A4 (de) * 2006-12-15 2011-01-05 Univ California Verwendung von cis-epoxyeicosatriensäuren und hemmern von löslicher epoxid-hydrolase zur behandlung von erkrankungen, die durch pbr, cb2 und nk hervorgerufen werden
EP2091542A1 (de) * 2006-12-18 2009-08-26 F. Hoffmann-Roche AG Neuartige verwendung von hemmern der löslichen epoxid-hydrolase
CN101663031A (zh) * 2007-02-20 2010-03-03 马泰克生物科学公司 来自长链多不饱和脂肪酸的氧脂素及其制备方法和使用方法
EP2178534A4 (de) * 2007-07-17 2011-03-30 Merck Sharp & Dohme Lösliche epoxidhydrolasehemmer, zusammensetzungen mit solchen verbindungen und behandlungsverfahren damit
WO2009086281A1 (en) * 2007-12-21 2009-07-09 Martek Biosciences Corporation Method for preparation of oxylipins
EP2135516B1 (de) * 2008-06-13 2012-08-15 Symrise AG Neo-Menthylderivate als Geschmacksstoffe
WO2010096722A1 (en) 2009-02-20 2010-08-26 Takeda Pharmaceutical Company Limited 3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors
US10383835B2 (en) 2012-03-14 2019-08-20 The Regents Of The University Of California Treatment of inflammatory disorders in non-human mammals
US20160008342A1 (en) 2014-06-16 2016-01-14 The Regents Of The University Of California Methods of improving cell-based therapy
US10813894B2 (en) 2015-02-20 2020-10-27 The Regents Of The University Of California Methods of inhibiting pain
EP3463470A1 (de) 2016-05-25 2019-04-10 Johann Wolfgang Goethe-Universität Frankfurt am Main Behandlung und diagnose von nichtproliferativer diabetischer retinopathie
WO2020074549A1 (en) 2018-10-10 2020-04-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and topical pharmaceutical compositions for the treatment of skin microvascular dysfunction

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US4088779A (en) * 1973-05-18 1978-05-09 Ciba-Geigy Corporation 9-Oxaprostaglandins
EP0360246B1 (de) * 1988-09-21 1994-03-30 G.D. Searle & Co. 3-Oxiranbenzoesäuren und Derivate
US5488033A (en) * 1989-07-28 1996-01-30 The Regents Of The University Of California Treatment to reduce edema
JP2635212B2 (ja) * 1990-04-30 1997-07-30 アイシス・ファーマシューティカルス・インコーポレーテッド アラキドン酸代謝のオリゴヌクレオチド変調
US5455271A (en) * 1992-06-18 1995-10-03 The Scripps Research Institute Tight-binding inhibitors of leukotriene A4 hydrolase
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5445956A (en) * 1993-08-13 1995-08-29 The Regents Of The University Of California Recombinant soluble epoxide hydrolase
US5503990A (en) * 1994-11-09 1996-04-02 Kurth; Gerhard D. Preparation of health food supplement product
US5504111A (en) * 1994-12-30 1996-04-02 Medichem Research, Inc. Use of 2,3 alkylcarbonyloxybenzoic acid in treating adult respiratory distress syndrome

Also Published As

Publication number Publication date
EP0926951A4 (de) 2001-08-08
ES2221064T3 (es) 2004-12-16
EP0926951B1 (de) 2004-04-21
WO1998006261A1 (en) 1998-02-19
CA2262525C (en) 2011-05-03
DE69728776D1 (de) 2004-05-27
DE69728776T2 (de) 2005-05-25
US5955496A (en) 1999-09-21
CA2262525A1 (en) 1998-02-19
AU4069297A (en) 1998-03-06
EP0926951A1 (de) 1999-07-07

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