ATE260665T1 - Derivate des erythromycins, des clarithromycins, des roxithromycins oder des azithromycin mit antibiotischer und mucolytischer wirkung - Google Patents
Derivate des erythromycins, des clarithromycins, des roxithromycins oder des azithromycin mit antibiotischer und mucolytischer wirkungInfo
- Publication number
- ATE260665T1 ATE260665T1 AT99947823T AT99947823T ATE260665T1 AT E260665 T1 ATE260665 T1 AT E260665T1 AT 99947823 T AT99947823 T AT 99947823T AT 99947823 T AT99947823 T AT 99947823T AT E260665 T1 ATE260665 T1 AT E260665T1
- Authority
- AT
- Austria
- Prior art keywords
- antibiotic
- mucolytic
- roxithromycin
- clarithromycin
- azithromycin
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 4
- 230000000510 mucolytic effect Effects 0.000 title abstract 4
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 3
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 title abstract 2
- 229960004099 azithromycin Drugs 0.000 title abstract 2
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 2
- 229960002626 clarithromycin Drugs 0.000 title abstract 2
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 title abstract 2
- 229960005224 roxithromycin Drugs 0.000 title abstract 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
- YTGJWQPHMWSCST-UHFFFAOYSA-N Tiopronin Chemical compound CC(S)C(=O)NCC(O)=O YTGJWQPHMWSCST-UHFFFAOYSA-N 0.000 abstract 1
- 108010058907 Tiopronin Proteins 0.000 abstract 1
- 229960004308 acetylcysteine Drugs 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- ZNEWHQLOPFWXOF-UHFFFAOYSA-N coenzyme M Chemical compound OS(=O)(=O)CCS ZNEWHQLOPFWXOF-UHFFFAOYSA-N 0.000 abstract 1
- 229960004100 dirithromycin Drugs 0.000 abstract 1
- WLOHNSSYAXHWNR-NXPDYKKBSA-N dirithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H]2O[C@H](COCCOC)N[C@H]([C@@H]2C)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 WLOHNSSYAXHWNR-NXPDYKKBSA-N 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229960001913 mecysteine Drugs 0.000 abstract 1
- 229960004635 mesna Drugs 0.000 abstract 1
- MCYHPZGUONZRGO-VKHMYHEASA-N methyl L-cysteinate Chemical compound COC(=O)[C@@H](N)CS MCYHPZGUONZRGO-VKHMYHEASA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
- 229960004402 tiopronin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE980869 | 1998-10-20 | ||
| IE981062 | 1998-12-17 | ||
| PCT/IE1999/000106 WO2000023081A1 (en) | 1998-10-20 | 1999-10-15 | Derivatives of erythromycin, clarithromycin, roxithromycin or azithromycin with antibiotic and mucolytic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE260665T1 true ATE260665T1 (de) | 2004-03-15 |
Family
ID=26320218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99947823T ATE260665T1 (de) | 1998-10-20 | 1999-10-15 | Derivate des erythromycins, des clarithromycins, des roxithromycins oder des azithromycin mit antibiotischer und mucolytischer wirkung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6599885B2 (de) |
| EP (1) | EP1121134B1 (de) |
| AT (1) | ATE260665T1 (de) |
| AU (1) | AU760884B2 (de) |
| CA (1) | CA2346870A1 (de) |
| DE (1) | DE69915327T2 (de) |
| WO (1) | WO2000023081A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0109544A (pt) * | 2000-03-28 | 2003-06-10 | Biochemie Gmbh | Partìculas granuladas com sabor ocultado |
| CA2614412A1 (en) * | 2005-07-07 | 2007-01-18 | Elan Pharma International, Limited | Nanoparticulate clarithromycin formulations |
| US20100022652A1 (en) * | 2008-07-28 | 2010-01-28 | Tyco Healthcare Group Lp | Antimicrobial and Anticoagulant Compositions and Methods |
| JP2013514346A (ja) * | 2009-12-18 | 2013-04-25 | ノース−ウエスト ユニヴァーシティ | アモルファス非晶質ガラス形態のアジスロマイシンを含む組成物 |
| CN104177457A (zh) * | 2013-05-23 | 2014-12-03 | 长春海悦药业有限公司 | 一种阿奇霉素药物原料及其制剂和用途 |
| WO2019010447A1 (en) | 2017-07-07 | 2019-01-10 | Epicentrx, Inc. | COMPOSITIONS FOR PARENTERAL ADMINISTRATION OF THERAPEUTIC AGENTS |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2824443A1 (de) | 1978-06-03 | 1979-12-13 | Basf Ag | Lagerstabile und fliessfaehige silikatsuspensionen |
| IT1134458B (it) * | 1980-11-26 | 1986-08-13 | Real Sas Di Alberto Reiner | Derivato della n-acetil-cisteina ad attivita' terapeutica,procedimento per la sua preparazione e relative composizioni farmaceutiche |
| IT1134457B (it) * | 1980-11-26 | 1986-08-13 | Real Sas Di Alberto Reiner | Derivato dell'alfa-mercapto propionilglicina ad attivita' terapeutica,procedimento per la sua preparazione e relative composizioni farmaceutiche |
| FR2519988B1 (fr) * | 1982-01-20 | 1985-06-14 | Refarmed Sa | Derives thioliques de l'erythromycine a activite therapeutique, procede de preparation et produits pharmaceutiques dans lesquels ils apparaissent |
| FR2502627A1 (fr) | 1981-02-02 | 1982-10-01 | Refarmed Sa | Derives thioliques de l'erythromycine a activite therapeutique, procede de preparation et produits pharmaceutiques dans lesquels ils apparaissent |
| IT1189285B (it) * | 1982-05-28 | 1988-02-04 | Nuovo Consor Sanitar Nazionale | Sali dell'antibiotico eritromicina e del suo estere propionico con acidi ad attivita' terapeutica coadiuvante |
| AU4399396A (en) * | 1994-12-19 | 1996-07-10 | Russinsky Limited | Compounds |
| CA2255124A1 (en) * | 1996-08-07 | 1998-02-12 | Helmut Schickaneder | A process for the production of pharmaceuticals |
-
1999
- 1999-10-15 CA CA002346870A patent/CA2346870A1/en not_active Abandoned
- 1999-10-15 AU AU61185/99A patent/AU760884B2/en not_active Ceased
- 1999-10-15 AT AT99947823T patent/ATE260665T1/de not_active IP Right Cessation
- 1999-10-15 EP EP99947823A patent/EP1121134B1/de not_active Expired - Lifetime
- 1999-10-15 DE DE69915327T patent/DE69915327T2/de not_active Expired - Fee Related
- 1999-10-15 WO PCT/IE1999/000106 patent/WO2000023081A1/en not_active Ceased
-
2001
- 2001-04-19 US US09/837,416 patent/US6599885B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69915327D1 (de) | 2004-04-08 |
| EP1121134B1 (de) | 2004-03-03 |
| EP1121134A1 (de) | 2001-08-08 |
| AU760884B2 (en) | 2003-05-22 |
| AU6118599A (en) | 2000-05-08 |
| CA2346870A1 (en) | 2000-04-27 |
| WO2000023081A1 (en) | 2000-04-27 |
| US6599885B2 (en) | 2003-07-29 |
| US20010031736A1 (en) | 2001-10-18 |
| DE69915327T2 (de) | 2005-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |