ATE233251T1 - Mmp-hemmende thiadiazolylamide - Google Patents
Mmp-hemmende thiadiazolylamideInfo
- Publication number
- ATE233251T1 ATE233251T1 AT97931009T AT97931009T ATE233251T1 AT E233251 T1 ATE233251 T1 AT E233251T1 AT 97931009 T AT97931009 T AT 97931009T AT 97931009 T AT97931009 T AT 97931009T AT E233251 T1 ATE233251 T1 AT E233251T1
- Authority
- AT
- Austria
- Prior art keywords
- ulceration
- present
- thiadiazolylamides
- mmp
- inhibiting
- Prior art date
Links
- 208000025865 Ulcer Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000036269 ulceration Effects 0.000 abstract 2
- 206010053555 Arthritis bacterial Diseases 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 208000004575 Infectious Arthritis Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 206010064996 Ulcerative keratitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 208000007565 gingivitis Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 201000001223 septic arthritis Diseases 0.000 abstract 1
- 108091007196 stromelysin Proteins 0.000 abstract 1
- -1 thiadiazole amide Chemical class 0.000 abstract 1
- 230000008354 tissue degradation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2018896P | 1996-06-21 | 1996-06-21 | |
| PCT/US1997/009204 WO1997048688A1 (en) | 1996-06-21 | 1997-06-18 | Thiadiazole amide mmp inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE233251T1 true ATE233251T1 (de) | 2003-03-15 |
Family
ID=21797214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97931009T ATE233251T1 (de) | 1996-06-21 | 1997-06-18 | Mmp-hemmende thiadiazolylamide |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5830869A (de) |
| EP (1) | EP1021424B1 (de) |
| JP (1) | JP2000514787A (de) |
| AT (1) | ATE233251T1 (de) |
| AU (1) | AU3474797A (de) |
| DE (1) | DE69719385T2 (de) |
| DK (1) | DK1021424T3 (de) |
| ES (1) | ES2193385T3 (de) |
| PT (1) | PT1021424E (de) |
| WO (1) | WO1997048688A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9702088D0 (en) | 1997-01-31 | 1997-03-19 | Pharmacia & Upjohn Spa | Matrix metalloproteinase inhibitors |
| NZ529903A (en) * | 2001-06-04 | 2005-09-30 | Axys Pharm Inc | Novel substituted 1,3-propadiamides as cathepsin inhibitors |
| JP4825375B2 (ja) * | 2001-08-28 | 2011-11-30 | 株式会社 資生堂 | ジチアゾール化合物及びマトリックスメタロプロテアーゼ活性阻害剤、皮膚外用剤 |
| CA2477423A1 (en) * | 2002-03-01 | 2003-09-12 | Merck & Co., Inc. | Aminoalkylphosphonates and related compounds as edg receptor agonists |
| AU2003300076C1 (en) | 2002-12-30 | 2010-03-04 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| EP1658072A4 (de) * | 2003-08-21 | 2009-03-25 | Pfizer Prod Inc | Verbindungen zur behandlung von neurodegenerativen erkrankungen |
| CN117417272A (zh) * | 2023-10-19 | 2024-01-19 | 上海海皋科技有限公司 | 一种Boc-D-异亮氨酸的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63142351A (ja) * | 1986-12-04 | 1988-06-14 | Fuji Photo Film Co Ltd | 直接ポジカラ−画像形成方法 |
| IT1224860B (it) * | 1988-07-29 | 1990-10-24 | Istituto Chimico Internazional | Composti correlati all'acetozolammi de con attivita' inibitrice dell'anidrasi carbonica, utili in particolare nel trattamento del glaucoma |
| AU641157B2 (en) * | 1989-05-02 | 1993-09-16 | G. Michael Blackburn | 2-imino-thiadiazoline-5-sulphonamides and their use in the treatment of glaucoma |
| AU4267293A (en) * | 1992-05-01 | 1993-11-29 | British Biotech Pharmaceuticals Limited | Use of MMP inhibitors |
| US5318964A (en) * | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
| AU7270794A (en) * | 1993-08-02 | 1995-02-28 | Celltech Limited | Succinamide derivatives, processes for their preparation and their use as gelatinase and collagenase inhibitors |
| GB9320660D0 (en) * | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
| US5403952A (en) * | 1993-10-08 | 1995-04-04 | Merck & Co., Inc. | Substituted cyclic derivatives as novel antidegenerative agents |
| ES2144819T3 (es) * | 1994-01-20 | 2000-06-16 | British Biotech Pharm | L-terc-leucina-2-piridilamida. |
| US5677282A (en) * | 1995-06-07 | 1997-10-14 | Proscript, Inc. | Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase |
| TW448172B (en) * | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| WO1997040031A1 (en) * | 1996-04-23 | 1997-10-30 | Pharmacia & Upjohn Company | Thiadiazolyl(thio)ureas useful as matrix metalloprotease inhibitors |
-
1997
- 1997-06-18 DK DK97931009T patent/DK1021424T3/da active
- 1997-06-18 JP JP10503000A patent/JP2000514787A/ja not_active Withdrawn
- 1997-06-18 US US08/878,266 patent/US5830869A/en not_active Expired - Fee Related
- 1997-06-18 WO PCT/US1997/009204 patent/WO1997048688A1/en active IP Right Grant
- 1997-06-18 AT AT97931009T patent/ATE233251T1/de not_active IP Right Cessation
- 1997-06-18 ES ES97931009T patent/ES2193385T3/es not_active Expired - Lifetime
- 1997-06-18 AU AU34747/97A patent/AU3474797A/en not_active Abandoned
- 1997-06-18 PT PT97931009T patent/PT1021424E/pt unknown
- 1997-06-18 EP EP97931009A patent/EP1021424B1/de not_active Expired - Lifetime
- 1997-06-18 DE DE69719385T patent/DE69719385T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU3474797A (en) | 1998-01-07 |
| EP1021424B1 (de) | 2003-02-26 |
| DE69719385T2 (de) | 2003-12-18 |
| DE69719385D1 (de) | 2003-04-03 |
| US5830869A (en) | 1998-11-03 |
| ES2193385T3 (es) | 2003-11-01 |
| WO1997048688A1 (en) | 1997-12-24 |
| EP1021424A1 (de) | 2000-07-26 |
| DK1021424T3 (da) | 2003-06-02 |
| PT1021424E (pt) | 2003-06-30 |
| JP2000514787A (ja) | 2000-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1021424 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |