ATE223483T1 - TRANSGENIC FISH WITH TISSUE-SPECIFIC EXPRESSION - Google Patents
TRANSGENIC FISH WITH TISSUE-SPECIFIC EXPRESSIONInfo
- Publication number
- ATE223483T1 ATE223483T1 AT98930088T AT98930088T ATE223483T1 AT E223483 T1 ATE223483 T1 AT E223483T1 AT 98930088 T AT98930088 T AT 98930088T AT 98930088 T AT98930088 T AT 98930088T AT E223483 T1 ATE223483 T1 AT E223483T1
- Authority
- AT
- Austria
- Prior art keywords
- transgenic fish
- fish
- tissue
- specific
- specific expression
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title abstract 5
- 241000251468 Actinopterygii Species 0.000 abstract 5
- 108700019146 Transgenes Proteins 0.000 abstract 3
- 230000018109 developmental process Effects 0.000 abstract 2
- 238000012423 maintenance Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Animal Husbandry (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Multicomponent Fibers (AREA)
Abstract
Disclosed are transgenic fish, and a method of making transgenic fish, which express transgenes in stable and predictable tissue- or developmentally-specific patterns. The transgenic fish contain transgene constructs with homologous expression sequences. Also disclosed are methods of using such transgenic fish. Such expression of transgenes allow the study of developmental processes, the relationship of cell lineages, the assessment of the effect of specific genes and compounds on the development or maintenance of specific tissues or cell lineages, and the maintenance of lines of fish bearing mutant genes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/871,755 US6380458B1 (en) | 1997-06-09 | 1997-06-09 | Cell-lineage specific expression in transgenic zebrafish |
PCT/US1998/011808 WO1998056902A2 (en) | 1997-06-09 | 1998-06-09 | Transgenic fish with tissue-specific expression |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE223483T1 true ATE223483T1 (en) | 2002-09-15 |
Family
ID=25358056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98930088T ATE223483T1 (en) | 1997-06-09 | 1998-06-09 | TRANSGENIC FISH WITH TISSUE-SPECIFIC EXPRESSION |
Country Status (11)
Country | Link |
---|---|
US (3) | US6380458B1 (en) |
EP (2) | EP0986640B1 (en) |
JP (1) | JP2002504821A (en) |
AT (1) | ATE223483T1 (en) |
AU (1) | AU754993B2 (en) |
CA (1) | CA2293722A1 (en) |
DE (1) | DE69807687T2 (en) |
DK (1) | DK0986640T3 (en) |
ES (1) | ES2179512T3 (en) |
PT (1) | PT986640E (en) |
WO (1) | WO1998056902A2 (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6380458B1 (en) * | 1997-06-09 | 2002-04-30 | Medical College Of Georgia Research Institute, Inc. | Cell-lineage specific expression in transgenic zebrafish |
ATE512233T1 (en) * | 1998-02-23 | 2011-06-15 | Phylonix Pharmaceuticals Inc | SCREENING METHOD FOR AGENTS ACTIVITY USING TELEOSTS |
US6656449B1 (en) * | 1998-02-23 | 2003-12-02 | Phylonix Pharmaceuticals, Inc. | Methods of screening agents for activity using teleosts |
US7951989B2 (en) * | 1998-02-23 | 2011-05-31 | Phylonix Pharmaceuticals, Inc. | Methods of screening agents for activity using teleosts |
WO2000049150A1 (en) * | 1999-02-18 | 2000-08-24 | National University Of Singapore | Chimeric gene constructs for generation of fluorescent transgenic ornamental fish |
SG82624A1 (en) * | 1999-02-18 | 2001-08-21 | Univ Singapore | Chimeric gene constructs for generation of fluorescent transgenic ornamental fish |
AU2001249297B2 (en) * | 2000-03-17 | 2006-11-23 | Anticancer, Inc. | Whole-body optical imaging of gene expression and uses thereof |
JP3354918B2 (en) * | 2000-06-08 | 2002-12-09 | 佑子 若松 | Transparent medaka |
WO2002034040A2 (en) * | 2000-10-23 | 2002-05-02 | Mermaid Pharmaceuticals Gmbh | Method for generating transgenic fish embryos using an episomal vector system |
WO2002081680A1 (en) * | 2001-04-05 | 2002-10-17 | Institute Of Molecular Agrobiology | Method for producing transgenic teleost fish |
JP2005502330A (en) * | 2001-07-17 | 2005-01-27 | ザ ジェネラル ホスピタル コーポレーション | Gastrointestinal diseases and conditions and methods for diagnosis and treatment of cancer |
US7615676B2 (en) * | 2001-11-30 | 2009-11-10 | U.S. Department Of Veterans Affairs | Transgenic screen and method for screening modulators of brain-derived neurotrophic factor (BDNF) production |
US7491810B2 (en) * | 2001-11-30 | 2009-02-17 | U.S. Department Of Veterans Affairs | Transgenic screen and method for screening modulators of brain-derived neurotrophic factor (BDNF) production |
GB2382579B (en) * | 2001-11-30 | 2003-11-12 | Daniolabs Ltd | Disease models, assays, methods and means |
EP1511376A4 (en) * | 2002-02-28 | 2007-08-29 | Zygogen Llc | Transgenic zebrafish models for thrombosis |
US7332647B2 (en) * | 2002-06-11 | 2008-02-19 | The Regents Of The University Of California | Fish produced by nuclear transfer from cultured cells |
US20040133114A1 (en) * | 2002-11-20 | 2004-07-08 | Macrae Calum A. | Zebrafish Assay |
US7465848B2 (en) * | 2002-11-20 | 2008-12-16 | The General Hospital Corporation | Zebrafish assay |
GB0228093D0 (en) * | 2002-12-02 | 2003-01-08 | Daniolabs Ltd | Disease models and uses thereof |
US20040194156A1 (en) * | 2002-12-27 | 2004-09-30 | Califa Llc | Transgenic aquatic invertebrates as a bioreactor for production of recombinant polypeptides |
US20050034677A1 (en) * | 2003-07-25 | 2005-02-17 | Alan Blake | Aquarium for transgenic fluorescent fish |
US6929095B2 (en) * | 2003-10-02 | 2005-08-16 | Carl H. Brygger | Roll-up stablizer |
GB0325284D0 (en) * | 2003-10-29 | 2003-12-03 | Forinnova As | Methods of identifying active genes |
US20060018833A1 (en) * | 2004-04-07 | 2006-01-26 | Randall Murphy | Method and system for screening compounds for muscular and/or neurological activity in animals |
CA2596267A1 (en) * | 2005-01-27 | 2006-08-03 | Zygogen, Llc | Zebrafish models for alzheimer's disease |
US8236937B2 (en) * | 2005-12-22 | 2012-08-07 | Indanio Bioscience Inc. | Methods and compositions for the detection and isolation of ligands |
US7663019B2 (en) * | 2006-05-24 | 2010-02-16 | North Carolina State University | Transgenic snakes and methods of making |
US8727554B2 (en) | 2007-06-25 | 2014-05-20 | Yorktown Technologies, L.P. | Aquarium with adjustable lighting |
US20090006219A1 (en) * | 2007-06-29 | 2009-01-01 | Alan Blake | Method for distribution of an aquarium kit |
US9968077B2 (en) | 2014-11-07 | 2018-05-15 | Glofish Llc | Blue transgenic fluorescent ornamental fish |
US20200113159A1 (en) * | 2017-03-30 | 2020-04-16 | GloFish, LLC | Transgenic rainbow shark |
EP3755144A4 (en) * | 2018-02-21 | 2021-12-01 | Nemametrix Inc. | Transgenic animal phenotyping platform and uses thereof |
EP3782465B1 (en) | 2019-08-23 | 2023-08-30 | Universität Potsdam | Transgenic zebrafish model for stroke |
CN114568343B (en) * | 2022-03-11 | 2023-04-07 | 成都合拓创展生物科技有限公司 | Headwear for preparing eye disease model and application thereof |
CN114931128B (en) * | 2022-06-30 | 2024-08-06 | 上海海洋大学 | Preparation method and application of hoxaa gene cluster deleted zebra fish mutant |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE203269T1 (en) | 1991-03-15 | 2001-08-15 | Hsc Res Dev Ltd Partnership | GENERATING FOR THE PRODUCTION OF TRANSGENIC FISH |
CA2126138C (en) | 1994-06-17 | 2001-08-21 | Robert H. Devlin | Transgenic fish and vectors therefor |
WO1996003034A1 (en) | 1994-07-27 | 1996-02-08 | Massachusetts Institute Of Technology | Method for retroviral vector insertion in fish |
EP0769021A2 (en) | 1995-04-06 | 1997-04-23 | Dalhousie University | Transgenic fish in the treatment of diabetes |
US6380458B1 (en) * | 1997-06-09 | 2002-04-30 | Medical College Of Georgia Research Institute, Inc. | Cell-lineage specific expression in transgenic zebrafish |
-
1997
- 1997-06-09 US US08/871,755 patent/US6380458B1/en not_active Expired - Lifetime
-
1998
- 1998-06-09 DE DE69807687T patent/DE69807687T2/en not_active Expired - Fee Related
- 1998-06-09 DK DK98930088T patent/DK0986640T3/en active
- 1998-06-09 JP JP50302899A patent/JP2002504821A/en active Pending
- 1998-06-09 AT AT98930088T patent/ATE223483T1/en not_active IP Right Cessation
- 1998-06-09 WO PCT/US1998/011808 patent/WO1998056902A2/en active IP Right Grant
- 1998-06-09 CA CA002293722A patent/CA2293722A1/en not_active Abandoned
- 1998-06-09 ES ES98930088T patent/ES2179512T3/en not_active Expired - Lifetime
- 1998-06-09 EP EP98930088A patent/EP0986640B1/en not_active Revoked
- 1998-06-09 PT PT98930088T patent/PT986640E/en unknown
- 1998-06-09 EP EP02000711A patent/EP1240824A1/en not_active Withdrawn
- 1998-06-09 AU AU79558/98A patent/AU754993B2/en not_active Ceased
-
2002
- 2002-04-30 US US10/136,734 patent/US20020178461A1/en not_active Abandoned
-
2009
- 2009-01-16 US US12/355,700 patent/US20100212038A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0986640B1 (en) | 2002-09-04 |
AU7955898A (en) | 1998-12-30 |
AU754993B2 (en) | 2002-11-28 |
WO1998056902A2 (en) | 1998-12-17 |
DK0986640T3 (en) | 2003-01-06 |
EP1240824A1 (en) | 2002-09-18 |
PT986640E (en) | 2002-12-31 |
DE69807687D1 (en) | 2002-10-10 |
US20100212038A1 (en) | 2010-08-19 |
JP2002504821A (en) | 2002-02-12 |
WO1998056902A3 (en) | 1999-03-04 |
EP0986640A2 (en) | 2000-03-22 |
DE69807687T2 (en) | 2003-01-02 |
CA2293722A1 (en) | 1998-12-17 |
US6380458B1 (en) | 2002-04-30 |
US20020178461A1 (en) | 2002-11-28 |
ES2179512T3 (en) | 2003-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee | ||
RZN | Patent revoked |