ATE221898T1 - COMPLEX DIRECTED MONOCLONAL ANTIBODIES AGAINST THROMBIN AND THROMBIN INHIBITORS - Google Patents

COMPLEX DIRECTED MONOCLONAL ANTIBODIES AGAINST THROMBIN AND THROMBIN INHIBITORS

Info

Publication number
ATE221898T1
ATE221898T1 AT91810748T AT91810748T ATE221898T1 AT E221898 T1 ATE221898 T1 AT E221898T1 AT 91810748 T AT91810748 T AT 91810748T AT 91810748 T AT91810748 T AT 91810748T AT E221898 T1 ATE221898 T1 AT E221898T1
Authority
AT
Austria
Prior art keywords
thrombin
monoclonal antibodies
derivatives
antibodies against
complex
Prior art date
Application number
AT91810748T
Other languages
German (de)
Inventor
Jean-Marc Dr Schlaeppi
Original Assignee
Novartis Erfind Verwalt Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh
Application granted granted Critical
Publication of ATE221898T1 publication Critical patent/ATE221898T1/en

Links

Abstract

The present invention relates to a process for the preparation of monoclonal antibodies which are directed against the thrombin/hirudin complex and derivatives thereof and of cell lines of hybridomas which secrete said monoclonal antibodies. The invention is also related to the use of monoclonal antibodies and/or derivatives thereof for the determination of the thrombin/hirudin complexes as well as test kits containing said monoclonal antibodies and/or derivatives thereof. More concretely, the present invention essentially relates to a process for the preparation of a monoclonal antibody which is directed against the thrombin/hirudin complex, and of a derivative thereof which maintains the specificity of the antibodies from which they are derived, which consists in the cells of a hybridoma cell line which secretes said antibody being propagated in vitro or in vivo and, when necessary, the monoclonal antibody obtained being isolated and/or converted into a derivative thereof.
AT91810748T 1990-10-02 1991-09-24 COMPLEX DIRECTED MONOCLONAL ANTIBODIES AGAINST THROMBIN AND THROMBIN INHIBITORS ATE221898T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909021370A GB9021370D0 (en) 1990-10-02 1990-10-02 Monoclonal antibodies directed against complexes formed by thrombin and thrombin inhibitors

Publications (1)

Publication Number Publication Date
ATE221898T1 true ATE221898T1 (en) 2002-08-15

Family

ID=10683074

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91810748T ATE221898T1 (en) 1990-10-02 1991-09-24 COMPLEX DIRECTED MONOCLONAL ANTIBODIES AGAINST THROMBIN AND THROMBIN INHIBITORS

Country Status (6)

Country Link
AT (1) ATE221898T1 (en)
DE (1) DE69133082D1 (en)
GB (1) GB9021370D0 (en)
IE (1) IE913458A1 (en)
PT (1) PT99114B (en)
SG (1) SG52676A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201816369T4 (en) * 2015-07-28 2018-11-21 Forschungszentrum Borstel Leibniz Lungenzentrum Improved bacterial endotoxin assay for endotoxin determination.

Also Published As

Publication number Publication date
PT99114B (en) 1999-02-26
DE69133082D1 (en) 2002-09-12
IE913458A1 (en) 1992-04-08
GB9021370D0 (en) 1990-11-14
SG52676A1 (en) 1998-09-28
PT99114A (en) 1992-08-31

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