ATE217864T1 - Indolin-2-on-derivate - Google Patents
Indolin-2-on-derivateInfo
- Publication number
- ATE217864T1 ATE217864T1 AT94907058T AT94907058T ATE217864T1 AT E217864 T1 ATE217864 T1 AT E217864T1 AT 94907058 T AT94907058 T AT 94907058T AT 94907058 T AT94907058 T AT 94907058T AT E217864 T1 ATE217864 T1 AT E217864T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- heterocycle
- aryl
- acyl
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6729793 | 1993-02-17 | ||
JP16726293 | 1993-05-31 | ||
PCT/JP1994/000235 WO1994019322A1 (en) | 1993-02-17 | 1994-02-17 | Indolin-2-one derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE217864T1 true ATE217864T1 (de) | 2002-06-15 |
Family
ID=26408486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94907058T ATE217864T1 (de) | 1993-02-17 | 1994-02-17 | Indolin-2-on-derivate |
Country Status (19)
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6878728B1 (en) | 1999-06-11 | 2005-04-12 | Vertex Pharmaceutical Incorporated | Inhibitors of aspartyl protease |
US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
US5783701A (en) | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
KR100235161B1 (ko) * | 1993-11-26 | 2001-11-22 | 찌바따 이찌로, 다나까 도시오 | 2-옥소인돌린 유도체 |
ES2139195T3 (es) * | 1994-03-07 | 2000-02-01 | Vertex Pharma | Derivados de sulfonamidas como inhibidores de la aspartil-proteasa. |
US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
US6004957A (en) * | 1995-06-07 | 1999-12-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
WO1997033867A1 (fr) * | 1996-03-11 | 1997-09-18 | Ube Industries, Ltd. | Procede de preparation de composes d'indole actifs sur le plan optique |
AU3459497A (en) * | 1996-07-12 | 1998-02-09 | Chugai Seiyaku Kabushiki Kaisha | Cancer cell proliferation inhibitors |
US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
AP1717A (en) | 1998-06-19 | 2007-01-30 | Vertex Pharma | Sulfonamide inhibitors of aspartyl protease. |
ATE285769T1 (de) * | 1998-12-04 | 2005-01-15 | Neurosearch As | Verwendung von isatinderivaten als ionenkanalaktivierende mittel |
US6605623B1 (en) | 1998-12-18 | 2003-08-12 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
EP1156037B1 (en) | 1999-01-29 | 2004-12-01 | Chugai Seiyaku Kabushiki Kaisha | Chondrongenesis promotors and indolin-2-one derivatives |
WO2000064872A1 (en) * | 1999-04-23 | 2000-11-02 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) |
US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
AU783504C (en) * | 1999-11-23 | 2006-08-03 | Methylgene Inc. | Inhibitors of histone deacetylase |
WO2001066142A1 (fr) * | 2000-03-10 | 2001-09-13 | Chugai Seiyaku Kabushiki Kaisha | Preparations pour chondrogenese |
US7612065B2 (en) | 2000-04-21 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-JUN N-terminal kinases (JNK) |
CA2413418A1 (en) * | 2000-06-21 | 2001-12-27 | Joseph B. Santella | Piperidine amides as modulators of chemokine receptor activity |
AU2001271357A1 (en) * | 2000-06-21 | 2002-01-02 | Dupont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
CA2508290C (en) | 2002-12-20 | 2017-02-28 | Ciba Specialty Chemicals Holding Inc. | Synthesis of amines and intermediates for the synthesis thereof |
CN1251698C (zh) * | 2003-01-30 | 2006-04-19 | 普文英 | 一种治疗内毒素血症的板蓝根提取物和用途 |
WO2008027692A2 (en) * | 2006-08-02 | 2008-03-06 | Abu-Ageel Nayef M | Led-based illumination system |
US20090050905A1 (en) * | 2007-08-20 | 2009-02-26 | Abu-Ageel Nayef M | Highly Efficient Light-Emitting Diode |
US20100202129A1 (en) * | 2009-01-21 | 2010-08-12 | Abu-Ageel Nayef M | Illumination system utilizing wavelength conversion materials and light recycling |
WO2011053542A1 (en) | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Heterocycle amide t-type calcium channel antagonists |
CN102516153B (zh) * | 2011-12-14 | 2014-03-12 | 南京工业大学 | 5-氟吲哚-2-酮-3-脲类化合物及其制备方法和应用 |
RU2693484C1 (ru) | 2013-11-22 | 2019-07-03 | СиЭль БАЙОСАЕНСИЗ ЭлЭлСи | Антагонисты гастрина для лечения и профилактики остеопороза |
KR102161674B1 (ko) * | 2014-02-18 | 2020-10-05 | 주식회사 대웅제약 | 이사틴 유도체 및 이의 제조방법 |
CN113456631B (zh) * | 2021-08-06 | 2022-06-21 | 徐州医科大学 | 一种靶向acsl1的小分子药物及其在治疗子宫内膜癌中的应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
JPS62234080A (ja) * | 1985-12-20 | 1987-10-14 | Kissei Pharmaceut Co Ltd | インドリン−2−オン誘導体 |
JPS62228072A (ja) * | 1985-12-20 | 1987-10-06 | Kissei Pharmaceut Co Ltd | 3−アミノインドリン−2−オン誘導体 |
US4760083A (en) * | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
JPS62270576A (ja) * | 1986-05-19 | 1987-11-24 | Kissei Pharmaceut Co Ltd | イサチン誘導体 |
JPS62156771A (ja) * | 1986-12-19 | 1987-07-11 | Tokyo Shokai:Kk | 処方箋処理装置 |
JPS63156771A (ja) * | 1986-12-19 | 1988-06-29 | Kissei Pharmaceut Co Ltd | 3−アミノインドリン−2−オン誘導体 |
US4876259A (en) * | 1987-01-05 | 1989-10-24 | E. I. Du Pont De Nemours And Company | 3,3-disubstituted indolines |
EP0336356A3 (en) * | 1988-04-05 | 1991-09-25 | Abbott Laboratories | Derivatives of tryptophan as cck antagonists |
NZ239591A (en) * | 1990-08-31 | 1994-07-26 | Warner Lambert Co | Tryptophan derivatives and pharmaceutical compositions |
WO1992007830A2 (en) | 1990-10-29 | 1992-05-14 | Pfizer Inc. | Oxindole peptide antagonists |
CA2055094A1 (en) * | 1990-11-13 | 1992-05-14 | Mark G. Bock | Cholecystokinin antagonist |
JPH05104510A (ja) * | 1991-10-18 | 1993-04-27 | Inax Corp | 基板へのモルタル塗布方法 |
-
1994
- 1994-02-16 TW TW083101206A patent/TW281669B/zh active
- 1994-02-16 MY MYPI94000344A patent/MY128102A/en unknown
- 1994-02-16 JP JP05654194A patent/JP3419539B2/ja not_active Expired - Fee Related
- 1994-02-17 HU HU9502415A patent/HUT74105A/hu unknown
- 1994-02-17 CZ CZ19952096A patent/CZ290504B6/cs not_active IP Right Cessation
- 1994-02-17 ES ES94907058T patent/ES2176236T3/es not_active Expired - Lifetime
- 1994-02-17 CA CA002156287A patent/CA2156287C/en not_active Expired - Fee Related
- 1994-02-17 KR KR1019950703395A patent/KR100226310B1/ko not_active IP Right Cessation
- 1994-02-17 CN CN94191205A patent/CN1046268C/zh not_active Expired - Fee Related
- 1994-02-17 DE DE69430664T patent/DE69430664T2/de not_active Expired - Fee Related
- 1994-02-17 AT AT94907058T patent/ATE217864T1/de not_active IP Right Cessation
- 1994-02-17 AU AU60448/94A patent/AU6044894A/en not_active Abandoned
- 1994-02-17 RU RU95120168A patent/RU2128170C1/ru not_active IP Right Cessation
- 1994-02-17 EP EP94907058A patent/EP0685463B1/en not_active Expired - Lifetime
- 1994-02-17 PL PL94310168A patent/PL176710B1/pl not_active IP Right Cessation
- 1994-02-17 WO PCT/JP1994/000235 patent/WO1994019322A1/ja active IP Right Grant
-
1995
- 1995-08-16 FI FI953866A patent/FI112652B/fi active
- 1995-08-17 NO NO953235A patent/NO305201B1/no unknown
-
1997
- 1997-11-03 US US08/963,547 patent/US5952511A/en not_active Expired - Fee Related
-
1998
- 1998-10-30 US US09/182,463 patent/US6114536A/en not_active Expired - Fee Related
- 1998-10-30 US US09/182,638 patent/US6031111A/en not_active Expired - Fee Related
- 1998-10-30 US US09/182,490 patent/US6207836B1/en not_active Expired - Fee Related
- 1998-10-30 US US09/182,491 patent/US6127544A/en not_active Expired - Fee Related
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |