ATE215380T1 - Verwendung von interleukin-12 fuer die verhinderung von transplantat gegen empfaengerkrankheit - Google Patents

Verwendung von interleukin-12 fuer die verhinderung von transplantat gegen empfaengerkrankheit

Info

Publication number
ATE215380T1
ATE215380T1 AT95908628T AT95908628T ATE215380T1 AT E215380 T1 ATE215380 T1 AT E215380T1 AT 95908628 T AT95908628 T AT 95908628T AT 95908628 T AT95908628 T AT 95908628T AT E215380 T1 ATE215380 T1 AT E215380T1
Authority
AT
Austria
Prior art keywords
interleukin
prevention
against recipient
transplant against
recipient disease
Prior art date
Application number
AT95908628T
Other languages
English (en)
Inventor
Stanley F Wolf
Megan Sykes
Original Assignee
Genetics Inst
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst, Gen Hospital Corp filed Critical Genetics Inst
Application granted granted Critical
Publication of ATE215380T1 publication Critical patent/ATE215380T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT95908628T 1994-01-21 1995-01-20 Verwendung von interleukin-12 fuer die verhinderung von transplantat gegen empfaengerkrankheit ATE215380T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/186,529 US5573764A (en) 1994-01-21 1994-01-21 Use of interleukin-12 to prevent graft versus host disease
PCT/US1995/000879 WO1995019786A1 (en) 1994-01-21 1995-01-20 Use of interleukin-12 to prevent graft versus host disease

Publications (1)

Publication Number Publication Date
ATE215380T1 true ATE215380T1 (de) 2002-04-15

Family

ID=22685309

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95908628T ATE215380T1 (de) 1994-01-21 1995-01-20 Verwendung von interleukin-12 fuer die verhinderung von transplantat gegen empfaengerkrankheit

Country Status (14)

Country Link
US (2) US5573764A (de)
EP (1) EP0739212B1 (de)
JP (1) JP3825043B2 (de)
AT (1) ATE215380T1 (de)
AU (1) AU698410B2 (de)
CA (1) CA2181568C (de)
DE (1) DE69526206T2 (de)
DK (1) DK0739212T3 (de)
ES (1) ES2179096T3 (de)
IL (1) IL112373A (de)
PT (1) PT739212E (de)
TW (1) TW349021B (de)
WO (1) WO1995019786A1 (de)
ZA (1) ZA95463B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573764A (en) * 1994-01-21 1996-11-12 Genetics Institute, Inc. Use of interleukin-12 to prevent graft versus host disease
US5674483A (en) * 1995-01-31 1997-10-07 National Jewish Medical And Research Center Treatment for diseases involving inflammation
JP2000510813A (ja) * 1995-02-06 2000-08-22 ジェネテイックス・インスティテュート・インコーポレイテッド Ｉｌ−１２用処方
WO1997016203A1 (en) * 1995-11-01 1997-05-09 Genetics Institute, Inc. Methods for administration of il-12
WO1998017689A2 (en) * 1996-10-18 1998-04-30 Valentis Inc. Il-12 gene expression and delivery systems and uses
EP0931156A2 (de) * 1996-10-18 1999-07-28 Valentis Inc. Genexpressions- und transfersysteme und deren verwendungen
WO1998034635A1 (en) * 1997-02-07 1998-08-13 The Wistar Institute Methods and compositions for the inhibition of interleukin-12 production
WO1998051327A1 (en) * 1997-05-16 1998-11-19 Toray Industries, Inc. Therapeutic agent, treatment method, prophylactic agent, and prophylactic method for canine and feline immunological diseases
EP1516630A3 (de) * 1997-10-31 2006-05-03 Wyeth Verwendung von anti-il-12 Antikörpern bei Transplantationsabstossungen
US6080399A (en) * 1998-04-23 2000-06-27 Arch Development Corporation Vaccine adjuvants for immunotherapy of melanoma
US7115712B1 (en) * 1999-12-02 2006-10-03 Maxygen, Inc. Cytokine polypeptides
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US7718196B2 (en) * 2001-07-02 2010-05-18 The United States Of America, As Represented By The Department Of Health And Human Services Rapamycin-resistant T cells and therapeutic uses thereof
WO2003038062A2 (en) * 2001-10-31 2003-05-08 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Generation of use of tc1 and tc2 cells
WO2003004625A1 (en) * 2001-07-02 2003-01-16 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Methods of generating human cd4+ th2 cells and uses thereof
AU2002336417A1 (en) * 2001-08-31 2003-03-18 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Methods of generating human cd4+ th1 cells
DE10248141B4 (de) * 2002-10-11 2007-04-19 Universitätsklinikum Hamburg-Eppendorf Nukleinsäuren und deren Verwendung für die Gentherapie
US7939058B2 (en) 2003-07-03 2011-05-10 University Of Southern California Uses of IL-12 in hematopoiesis
JP2010539993A (ja) * 2007-10-08 2010-12-24 イントレキソン コーポレーション 遺伝子操作した樹状細胞および癌の治療のための使用
US20100272863A1 (en) * 2009-04-24 2010-10-28 Griebel Jonathan M Soft shaped tortillas
EP2571516B1 (de) 2010-05-18 2017-11-15 Neumedicines, Inc Formulierungen enthaltend il-12 zur erhöhung der hematopoese
WO2012174056A1 (en) 2011-06-13 2012-12-20 Neumedicines, Inc. Mitigation of cutaneous injury with il-12
EP2736530B1 (de) 2011-07-27 2018-06-06 Neumedicines, Inc Verwendung von il-12 zur erzeugung von endogenem erythropoetin
PL3351261T3 (pl) * 2011-10-11 2021-12-06 Universität Zürich Lek złożony zawierający IL-12 i środek do blokowania cząsteczek hamujących komórki T w terapii nowotworów
US11951157B2 (en) 2011-10-11 2024-04-09 Universitat Zurich Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody
US9636381B2 (en) 2012-01-18 2017-05-02 Neumedicines, Inc. Methods for radiation protection by administering IL-12
WO2013158959A1 (en) * 2012-04-19 2013-10-24 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of graft-versus-host disease
JP7851612B2 (ja) * 2020-04-17 2026-04-27 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 改変ｉｌ－１２及びｉｌ－２３ポリペプチドとその使用
JP2023548746A (ja) * 2020-10-13 2023-11-21 クリヤ セラピューティクス インコーポレイテッド サイトカインをコードする核酸を送達するためのウイルスベクターコンストラクトおよびがんを処置するためのその使用
IL312221A (en) 2021-10-20 2024-06-01 Synthekine Inc Heterodimeric fc cytokines and uses thereof
JP2025503454A (ja) * 2021-12-17 2025-02-04 ウィリアム マーシュ ライス ユニバーシティ Ｉｌ－１２を発現するカプセル化細胞及びその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ249754A (en) * 1992-03-04 1997-06-24 Schering Corp Interleukin-10 and its use in inhibiting graft vs host disease or tissue rejection
DE4315127A1 (de) * 1993-05-07 1994-11-10 Behringwerke Ag Arzneimittel enthaltend die Untereinheit p40 von Interleukin-12
US5573764A (en) * 1994-01-21 1996-11-12 Genetics Institute, Inc. Use of interleukin-12 to prevent graft versus host disease

Also Published As

Publication number Publication date
US5573764A (en) 1996-11-12
US5756085A (en) 1998-05-26
DE69526206D1 (de) 2002-05-08
EP0739212B1 (de) 2002-04-03
JP3825043B2 (ja) 2006-09-20
DE69526206T2 (de) 2002-11-21
DK0739212T3 (da) 2002-06-03
ZA95463B (en) 1995-09-27
PT739212E (pt) 2002-08-30
JPH09508371A (ja) 1997-08-26
EP0739212A1 (de) 1996-10-30
AU698410B2 (en) 1998-10-29
WO1995019786A1 (en) 1995-07-27
IL112373A (en) 2006-08-01
ES2179096T3 (es) 2003-01-16
CA2181568C (en) 2007-09-18
TW349021B (en) 1999-01-01
IL112373A0 (en) 1995-03-30
AU1687595A (en) 1995-08-08
CA2181568A1 (en) 1995-07-27

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