ATE213728T1 - Verfahren zur herstellung von peptidyl- argininaldehyden - Google Patents
Verfahren zur herstellung von peptidyl- argininaldehydenInfo
- Publication number
- ATE213728T1 ATE213728T1 AT95925259T AT95925259T ATE213728T1 AT E213728 T1 ATE213728 T1 AT E213728T1 AT 95925259 T AT95925259 T AT 95925259T AT 95925259 T AT95925259 T AT 95925259T AT E213728 T1 ATE213728 T1 AT E213728T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- group
- hydrogen
- peptidyl
- argininal
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 isonicotinyloxycarbonyl Chemical group 0.000 abstract 10
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000005076 adamantyloxycarbonyl group Chemical group C12(CC3CC(CC(C1)C3)C2)OC(=O)* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 125000001151 peptidyl group Chemical group 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Chemical group O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/261,380 US5514777A (en) | 1994-06-17 | 1994-06-17 | Methods of synthesis of peptidyl argininals |
| US08/482,281 US5731413A (en) | 1994-06-17 | 1995-06-07 | Method of synthesis of peptidyl aldehydes |
| PCT/US1995/007666 WO1995035280A1 (en) | 1994-06-17 | 1995-06-19 | Methods of synthesis of peptidyl argininals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE213728T1 true ATE213728T1 (de) | 2002-03-15 |
Family
ID=26948565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95925259T ATE213728T1 (de) | 1994-06-17 | 1995-06-19 | Verfahren zur herstellung von peptidyl- argininaldehyden |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0790982B1 (de) |
| AT (1) | ATE213728T1 (de) |
| AU (1) | AU701503B2 (de) |
| CA (1) | CA2192697A1 (de) |
| DE (1) | DE69525641T2 (de) |
| NZ (1) | NZ289562A (de) |
| WO (1) | WO1995035280A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872827B2 (en) | 2002-04-26 | 2005-03-29 | Chembridge Research Laboratories, Inc. | Somatostatin analogue compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177098B (en) * | 1979-01-04 | 1981-07-28 | Gyogyszerkutato Intezet | Process for producing new peptidyl-n-carboxy-l-arginin-a |
| HU192646B (en) * | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
| CA2075154A1 (en) * | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
-
1995
- 1995-06-19 DE DE69525641T patent/DE69525641T2/de not_active Expired - Lifetime
- 1995-06-19 NZ NZ289562A patent/NZ289562A/xx not_active IP Right Cessation
- 1995-06-19 CA CA002192697A patent/CA2192697A1/en not_active Abandoned
- 1995-06-19 EP EP95925259A patent/EP0790982B1/de not_active Expired - Lifetime
- 1995-06-19 AT AT95925259T patent/ATE213728T1/de not_active IP Right Cessation
- 1995-06-19 AU AU29448/95A patent/AU701503B2/en not_active Ceased
- 1995-06-19 WO PCT/US1995/007666 patent/WO1995035280A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0790982B1 (de) | 2002-02-27 |
| EP0790982A1 (de) | 1997-08-27 |
| AU701503B2 (en) | 1999-01-28 |
| CA2192697A1 (en) | 1995-12-28 |
| WO1995035280A1 (en) | 1995-12-28 |
| DE69525641D1 (de) | 2002-04-04 |
| AU2944895A (en) | 1996-01-15 |
| DE69525641T2 (de) | 2002-10-17 |
| NZ289562A (en) | 1998-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |