ATE204604T1 - Strukturanaloge von fibroblasten- wachstumsfaktoren, die eine modifizierte heparin- bindungsstelle aufweisen - Google Patents
Strukturanaloge von fibroblasten- wachstumsfaktoren, die eine modifizierte heparin- bindungsstelle aufweisenInfo
- Publication number
- ATE204604T1 ATE204604T1 AT94114212T AT94114212T ATE204604T1 AT E204604 T1 ATE204604 T1 AT E204604T1 AT 94114212 T AT94114212 T AT 94114212T AT 94114212 T AT94114212 T AT 94114212T AT E204604 T1 ATE204604 T1 AT E204604T1
- Authority
- AT
- Austria
- Prior art keywords
- heparin binding
- binding site
- growth factors
- fibroblast growth
- analogues
- Prior art date
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 3
- 102000018233 Fibroblast Growth Factor Human genes 0.000 title abstract 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 title abstract 2
- 230000035772 mutation Effects 0.000 abstract 3
- 239000003102 growth factor Substances 0.000 abstract 2
- 229960002897 heparin Drugs 0.000 abstract 2
- 229920000669 heparin Polymers 0.000 abstract 2
- 108010001857 Cell Surface Receptors Proteins 0.000 abstract 1
- 230000010556 Heparin Binding Activity Effects 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 102000006240 membrane receptors Human genes 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12697493A | 1993-09-24 | 1993-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE204604T1 true ATE204604T1 (de) | 2001-09-15 |
Family
ID=22427669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94114212T ATE204604T1 (de) | 1993-09-24 | 1994-09-09 | Strukturanaloge von fibroblasten- wachstumsfaktoren, die eine modifizierte heparin- bindungsstelle aufweisen |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0645451B1 (enExample) |
| JP (1) | JPH07149797A (enExample) |
| KR (1) | KR100320803B1 (enExample) |
| AT (1) | ATE204604T1 (enExample) |
| AU (1) | AU680533B2 (enExample) |
| CA (1) | CA2132668A1 (enExample) |
| DE (1) | DE69428013T2 (enExample) |
| DK (1) | DK0645451T3 (enExample) |
| ES (1) | ES2161233T3 (enExample) |
| NZ (1) | NZ264529A (enExample) |
| PT (1) | PT645451E (enExample) |
| TW (1) | TW275068B (enExample) |
| ZA (1) | ZA947454B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127116A (en) * | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
| US5874565A (en) * | 1995-08-29 | 1999-02-23 | Washington University | Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus |
| US7049428B1 (en) | 1998-03-04 | 2006-05-23 | Washington University | HCV variants |
| US7338759B1 (en) | 1997-03-04 | 2008-03-04 | Washington University | HCV variants |
| AU3170499A (en) * | 1998-04-28 | 1999-11-16 | Eisai Co. Ltd. | Fibroblast growth factor mutein compositions and methods of use therefor |
| JP5767314B2 (ja) | 2010-04-16 | 2015-08-19 | ソーク インスティチュート フォー バイオロジカル スタディーズ | Ｆｇｆを用いて代謝障害を処置するための方法 |
| US9475856B2 (en) | 2012-03-02 | 2016-10-25 | New York University | Chimeric FGF21 proteins with enhanced binding affinity for β-klotho for the treatment of type II diabetes, obesity, and related metabolic disorders |
| US9657075B2 (en) | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| US9474785B2 (en) | 2012-06-07 | 2016-10-25 | New York University | Chimeric fibroblast growth factor 19 proteins and methods of use |
| US9464126B2 (en) | 2012-06-07 | 2016-10-11 | New York University | Chimeric fibroblast growth factor 21 proteins and methods of use |
| US9550820B2 (en) | 2013-02-22 | 2017-01-24 | New York University | Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use |
| WO2015061331A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use |
| CN105828833A (zh) | 2013-10-21 | 2016-08-03 | 萨克生物研究学院 | 突变的成纤维细胞生长因子（fgf）1及使用方法 |
| CA3002400A1 (en) | 2015-10-30 | 2017-05-04 | Salk Institute For Biological Studies | Treatment of steroid-induced hyperglycemia with fibroblast growth factor (fgf) 1 analogs |
| KR20170109207A (ko) * | 2016-03-17 | 2017-09-28 | 중앙대학교 산학협력단 | 화학반응을 통하여 결합된 섬유아세포 증식인자-헤파린 복합체 및 이의 제조 방법 |
| US11229681B2 (en) * | 2017-07-14 | 2022-01-25 | The Regents Of The University Of California | Dominant-negative FGF2 antagonists |
| US11542309B2 (en) | 2019-07-31 | 2023-01-03 | Salk Institute For Biological Studies | Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose |
| CN116042681A (zh) * | 2022-08-01 | 2023-05-02 | 普纳思细胞(厦门)生物科技有限公司 | 一种bFGF热稳定性改造的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2879148B2 (ja) * | 1987-07-07 | 1999-04-05 | サイオス インコーポレイテッド | 組換え繊維芽細胞成長因子 |
| WO1989004832A1 (en) * | 1987-11-24 | 1989-06-01 | Amgen Inc. | Analogs of fibroblast growth factor |
| GB8821795D0 (en) * | 1988-09-16 | 1988-10-19 | Erba Carlo Spa | New derivatives of human/bovine basic fibroplast growth factor |
-
1993
- 1993-12-01 TW TW082110137A patent/TW275068B/zh active
-
1994
- 1994-09-09 DK DK94114212T patent/DK0645451T3/da active
- 1994-09-09 AT AT94114212T patent/ATE204604T1/de not_active IP Right Cessation
- 1994-09-09 EP EP94114212A patent/EP0645451B1/en not_active Expired - Lifetime
- 1994-09-09 PT PT94114212T patent/PT645451E/pt unknown
- 1994-09-09 ES ES94114212T patent/ES2161233T3/es not_active Expired - Lifetime
- 1994-09-09 DE DE69428013T patent/DE69428013T2/de not_active Expired - Fee Related
- 1994-09-22 JP JP6252766A patent/JPH07149797A/ja active Pending
- 1994-09-22 CA CA002132668A patent/CA2132668A1/en not_active Abandoned
- 1994-09-23 AU AU74185/94A patent/AU680533B2/en not_active Ceased
- 1994-09-23 KR KR1019940024025A patent/KR100320803B1/ko not_active Expired - Fee Related
- 1994-09-23 ZA ZA947454A patent/ZA947454B/xx unknown
- 1994-09-23 NZ NZ264529A patent/NZ264529A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT645451E (pt) | 2001-12-28 |
| EP0645451A1 (en) | 1995-03-29 |
| NZ264529A (en) | 1997-06-24 |
| ES2161233T3 (es) | 2001-12-01 |
| JPH07149797A (ja) | 1995-06-13 |
| ZA947454B (en) | 1995-05-15 |
| AU680533B2 (en) | 1997-07-31 |
| DE69428013D1 (de) | 2001-09-27 |
| CA2132668A1 (en) | 1995-03-25 |
| TW275068B (enExample) | 1996-05-01 |
| AU7418594A (en) | 1995-04-06 |
| DE69428013T2 (de) | 2002-05-29 |
| KR100320803B1 (ko) | 2002-06-20 |
| DK0645451T3 (da) | 2001-10-08 |
| EP0645451B1 (en) | 2001-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |