ATE202933T1 - Immunpotentierende und infektionsschnützende verbindung und ihre herstellung - Google Patents

Immunpotentierende und infektionsschnützende verbindung und ihre herstellung

Info

Publication number
ATE202933T1
ATE202933T1 AT92919503T AT92919503T ATE202933T1 AT E202933 T1 ATE202933 T1 AT E202933T1 AT 92919503 T AT92919503 T AT 92919503T AT 92919503 T AT92919503 T AT 92919503T AT E202933 T1 ATE202933 T1 AT E202933T1
Authority
AT
Austria
Prior art keywords
production
immunopotentive
infection protective
protective compound
riboflavin
Prior art date
Application number
AT92919503T
Other languages
English (en)
Inventor
Seiichi Araki
Mamoru Suzuki
Masatoshi Fujimoto
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ATE202933T1 publication Critical patent/ATE202933T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/12—Heterocyclic compounds containing pteridine ring systems containing pteridine ring systems condensed with carbocyclic rings or ring systems
    • C07D475/14—Benz [g] pteridines, e.g. riboflavin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT92919503T 1991-09-13 1992-09-09 Immunpotentierende und infektionsschnützende verbindung und ihre herstellung ATE202933T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26128891 1991-09-13
PCT/JP1992/001146 WO1993005784A1 (en) 1991-09-13 1992-09-09 Immunopotentiating and infection protective agent and production thereof

Publications (1)

Publication Number Publication Date
ATE202933T1 true ATE202933T1 (de) 2001-07-15

Family

ID=17359726

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92919503T ATE202933T1 (de) 1991-09-13 1992-09-09 Immunpotentierende und infektionsschnützende verbindung und ihre herstellung

Country Status (11)

Country Link
US (2) US5814632A (de)
EP (2) EP1086696A3 (de)
AT (1) ATE202933T1 (de)
AU (1) AU671421B2 (de)
CA (1) CA2118792C (de)
DE (1) DE69231936T2 (de)
ES (1) ES2157906T3 (de)
MY (1) MY110518A (de)
NZ (1) NZ244270A (de)
TW (1) TW279802B (de)
WO (1) WO1993005784A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9321558D0 (en) * 1993-10-19 1993-12-08 Radopath Ltd Anti-viral agents
GB2319474A (en) * 1993-10-19 1998-05-27 Radopath Ltd Anti-viral agents
IT1306141B1 (it) * 1999-05-17 2001-05-30 Giampiero Valletta Composizione per il trattamento del prurito uremico e di forme diprurito non riconducibili a lesioni organiche.
US6268120B1 (en) * 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
US7648699B2 (en) 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
TW590780B (en) 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US7985588B2 (en) 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US6548241B1 (en) 2000-11-28 2003-04-15 Gambro, Inc. Storage solution containing photosensitizer for inactivation of biological contaminants
WO2002074313A1 (en) * 2001-03-21 2002-09-26 Eisai Co., Ltd. Drugs containing reduced vitamin b¿2?
US7235392B2 (en) * 2001-12-07 2007-06-26 The Ohio State University Research Foundation Apoptotic EBV-transformed lymphocytes, a therapeutic agent for post-transplant lymphoproliferative disorder
US20040038373A1 (en) * 2001-12-07 2004-02-26 Platz Matthew S. Apoptotic EBV-transformed lymphocytes, a therapeutic agent for post-transplant lymphoproliferative disorder
WO2003075935A1 (fr) * 2002-03-11 2003-09-18 Eisai Co., Ltd. Medicaments contenant des composes du type riboflavine
JP4355578B2 (ja) * 2002-04-09 2009-11-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 リボフラビン系化合物を含む医薬
AU2003299486A1 (en) * 2002-05-10 2004-06-03 The Ohio State University Flavin n-oxides: new anti-cancer agents and pathogen eradication agents
AU2007237685B2 (en) * 2006-03-15 2012-08-09 Suntory Holdings Limited Compositions containing riboflavin and sesamin-class compounds
WO2008126587A1 (ja) 2007-03-15 2008-10-23 Suntory Holdings Limited 抗疲労剤

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1360228A (en) * 1971-07-30 1974-07-17 Takeda Yakuhin Kk Veterinary antibiotic preparations
US4219545A (en) * 1979-03-23 1980-08-26 Collins Calvin E Treatment of infectious keratoconjunctivitis in animals
WO1984001899A1 (en) * 1982-11-16 1984-05-24 Georges Motschan New utilization of a unique vitamin or a combination of various vitamins
US4708952A (en) * 1985-02-06 1987-11-24 Aida Salatinjants Method of treatment of the infectious and viral diseases by one time interference
AU587863B2 (en) * 1985-10-07 1989-08-31 Basf Aktiengesellschaft Vitamin-containing granules and production thereof
US4871550A (en) * 1986-09-05 1989-10-03 Millman Phillip L Nutrient composition for athletes and method of making and using the same
FI892006A (fi) * 1988-04-29 1989-10-30 Phil Gold Lactalbumin saosom tillaeggsaemne i mat.
JPH02265458A (ja) * 1989-04-04 1990-10-30 Nikken Food Kk 老化制御食品
US5000888A (en) * 1990-05-23 1991-03-19 Basf Corporation Process for spray drying riboflavin to produce a granulate product having low binder content
FR2674753B1 (fr) * 1991-04-02 1995-03-10 Jean Berque Nouvelles indications therapeutiques, en particulier pour le traitement du sida, d'un medicament deja existant et fabrique a partir d'une molecule denuee de contre-indications et d'effets indesirables.
JPH05163160A (ja) * 1991-12-13 1993-06-29 Snow Brand Milk Prod Co Ltd 免疫低下に伴う感染症の予防及び治療用栄養剤

Also Published As

Publication number Publication date
EP0679398B1 (de) 2001-07-11
CA2118792A1 (en) 1993-04-01
US5945420A (en) 1999-08-31
DE69231936T2 (de) 2001-12-13
NZ244270A (en) 1995-07-26
US5814632A (en) 1998-09-29
AU671421B2 (en) 1996-08-29
EP1086696A2 (de) 2001-03-28
AU2562892A (en) 1993-04-27
EP0679398A4 (de) 1994-08-19
ES2157906T3 (es) 2001-09-01
WO1993005784A1 (en) 1993-04-01
EP1086696A3 (de) 2004-01-02
DE69231936D1 (de) 2001-08-16
MY110518A (en) 1998-07-31
CA2118792C (en) 2006-08-22
TW279802B (de) 1996-07-01
EP0679398A1 (de) 1995-11-02

Similar Documents

Publication Publication Date Title
ATE202933T1 (de) Immunpotentierende und infektionsschnützende verbindung und ihre herstellung
ATE121295T1 (de) Augentropfenarzneimittel.
TW273550B (de)
PT825186E (pt) Derivados de 2-aminobenzazepina e sua utilizacao para o tratamento da imunossupressao
AU4445089A (en) Lactamimides in the treatment of drug-resistant protozoal infections
WO1990006307A3 (en) Antibacterial quinolone compounds
ES2060293T3 (es) Nueva sustancia antiulcerosa.
GB9018603D0 (en) Compositions
AU4574689A (en) Phenoxy and phenylthio, amino substituted benzocycloalkane derivatives in the treatment and prevention of drug-resistant protozoal infections
NZ228023A (en) 24(r)-scymnol; preparatory processes and pharmaceutical compositions
DK0579939T3 (da) Phospholipidderivater
KR960703127A (ko) 구충제로서 유용한 14-치환된 마르크포틴 및 유도체(14-substituted marcfortin and derivatives useful as antiparasitic agents)
ATE80873T1 (de) Tetrahydropyridin-derivate.
EP0427402A3 (en) Treatment of shock by cyclodextrins and their derivatives
WO1994012483A3 (de) Thiocyanatomethylthiobenzthiazol-derivate
TH27429EX (th) อุปกรณ์สำหรับขยายเสียงพูด

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner