ATE200485T1 - Verfahren zur herstellung und isolierung von atracurium besylate - Google Patents

Verfahren zur herstellung und isolierung von atracurium besylate

Info

Publication number
ATE200485T1
ATE200485T1 AT97905920T AT97905920T ATE200485T1 AT E200485 T1 ATE200485 T1 AT E200485T1 AT 97905920 T AT97905920 T AT 97905920T AT 97905920 T AT97905920 T AT 97905920T AT E200485 T1 ATE200485 T1 AT E200485T1
Authority
AT
Austria
Prior art keywords
atracurium besylate
besylate
isolation
production
reaction mixture
Prior art date
Application number
AT97905920T
Other languages
English (en)
Inventor
Steven A Chamberlin
Ashok V Bhatia
Deborah A Davis
Keith A Drengler
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE200485T1 publication Critical patent/ATE200485T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Element Separation (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Paints Or Removers (AREA)
  • Organic Insulating Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT97905920T 1996-02-16 1997-02-12 Verfahren zur herstellung und isolierung von atracurium besylate ATE200485T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/602,945 US5684154A (en) 1996-02-16 1996-02-16 Process for the preparation and isolation of atracurium besylate
PCT/US1997/002196 WO1997030033A1 (en) 1996-02-16 1997-02-12 Process for the preparation and isolation of atracurium besylate

Publications (1)

Publication Number Publication Date
ATE200485T1 true ATE200485T1 (de) 2001-04-15

Family

ID=24413409

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97905920T ATE200485T1 (de) 1996-02-16 1997-02-12 Verfahren zur herstellung und isolierung von atracurium besylate

Country Status (10)

Country Link
US (1) US5684154A (de)
EP (1) EP0882020B1 (de)
JP (1) JP2000513328A (de)
AT (1) ATE200485T1 (de)
DE (1) DE69704553T2 (de)
DK (1) DK0882020T3 (de)
ES (1) ES2158499T3 (de)
GR (1) GR3036083T3 (de)
PT (1) PT882020E (de)
WO (1) WO1997030033A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2101772B1 (de) * 2006-12-06 2012-04-25 Cornell Research Foundation, Inc. Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
AU2008222298A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
US20100087650A1 (en) * 2007-03-26 2010-04-08 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
WO2009007946A1 (en) * 2007-07-09 2009-01-15 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
AU2008243747B2 (en) * 2007-05-01 2013-03-07 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
EP2155684B1 (de) * 2007-05-01 2014-04-09 Chemagis Ltd. Verfahren zur herstellung von cisatracuriumverbindungen und damit assoziierte zwischenprodukte
US8357805B2 (en) * 2007-06-18 2013-01-22 Chemagis Ltd. (1R,1′R)-atracurium salts separation process
US8354537B2 (en) * 2007-10-29 2013-01-15 Chemagis Ltd. R,R1-atracurium salts
WO2009133556A2 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
CN102573794B (zh) 2009-08-19 2017-03-15 康奈尔大学 供生理注射用的半胱氨酸
CN114014806A (zh) * 2021-12-03 2022-02-08 江苏诚信药业有限公司 一种新晶型顺苯磺酸阿曲库铵及其结晶方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
GB1579822A (en) * 1976-10-29 1980-11-26 Wellcome Found Tetrahydroisoquinolinium muscle relaxants
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
GB9015473D0 (en) * 1990-07-13 1990-08-29 Wellcome Found Neuromuscular blocking agents

Also Published As

Publication number Publication date
DE69704553T2 (de) 2001-11-08
WO1997030033A1 (en) 1997-08-21
JP2000513328A (ja) 2000-10-10
EP0882020A1 (de) 1998-12-09
PT882020E (pt) 2001-09-28
EP0882020B1 (de) 2001-04-11
DK0882020T3 (da) 2001-08-20
GR3036083T3 (en) 2001-09-28
ES2158499T3 (es) 2001-09-01
DE69704553D1 (de) 2001-05-17
US5684154A (en) 1997-11-04

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Legal Events

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