ATE197456T1 - Verfahren zur herstellung von zwischenprodukten von carbapenem-seitenketten - Google Patents
Verfahren zur herstellung von zwischenprodukten von carbapenem-seitenkettenInfo
- Publication number
- ATE197456T1 ATE197456T1 AT96926210T AT96926210T ATE197456T1 AT E197456 T1 ATE197456 T1 AT E197456T1 AT 96926210 T AT96926210 T AT 96926210T AT 96926210 T AT96926210 T AT 96926210T AT E197456 T1 ATE197456 T1 AT E197456T1
- Authority
- AT
- Austria
- Prior art keywords
- side chain
- intermediate products
- compound
- chain intermediate
- formula
- Prior art date
Links
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical group C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000012359 Methanesulfonyl chloride Substances 0.000 abstract 1
- QPQGTZMAQRXCJW-UHFFFAOYSA-N [chloro(phenyl)phosphoryl]benzene Chemical compound C=1C=CC=CC=1P(=O)(Cl)C1=CC=CC=C1 QPQGTZMAQRXCJW-UHFFFAOYSA-N 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- VDQVEACBQKUUSU-UHFFFAOYSA-M disodium;sulfanide Chemical compound [Na+].[Na+].[SH-] VDQVEACBQKUUSU-UHFFFAOYSA-M 0.000 abstract 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 abstract 1
- 229910052979 sodium sulfide Inorganic materials 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US189195P | 1995-08-04 | 1995-08-04 | |
| GBGB9602881.6A GB9602881D0 (en) | 1996-02-13 | 1996-02-13 | Process for synthesizing carbapenem side chain intermediates |
| PCT/US1996/012552 WO1997006154A1 (en) | 1995-08-04 | 1996-07-31 | Process for synthesizing carbapenem side chain intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE197456T1 true ATE197456T1 (de) | 2000-11-11 |
Family
ID=26308673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96926210T ATE197456T1 (de) | 1995-08-04 | 1996-07-31 | Verfahren zur herstellung von zwischenprodukten von carbapenem-seitenketten |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0842166B1 (de) |
| JP (1) | JP3112952B2 (de) |
| AT (1) | ATE197456T1 (de) |
| AU (1) | AU704304B2 (de) |
| CA (1) | CA2227696C (de) |
| DE (1) | DE69610924T2 (de) |
| DK (1) | DK0842166T3 (de) |
| ES (1) | ES2151671T3 (de) |
| GR (1) | GR3034795T3 (de) |
| PT (1) | PT842166E (de) |
| WO (1) | WO1997006154A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063931A (en) * | 1997-07-09 | 2000-05-16 | Merck & Co., Inc. | Process for synthesizing carbapenem side chain intermediates |
| AU731586B2 (en) * | 1997-07-09 | 2001-04-05 | Merck Sharp & Dohme Corp. | Process for synthesizing carbapenem side chain intermediates |
| US5965747A (en) * | 1997-07-10 | 1999-10-12 | Merck & Co., Inc. | Crystalline forms of antibiotic side chain intermediates |
| US6060607A (en) * | 1998-06-29 | 2000-05-09 | Merck & Co., Inc. | Process for synthesizing carbapenem side chain intermediates |
| CA2401643A1 (en) | 2000-03-01 | 2001-09-07 | Merck & Co., Inc. | Crystalline forms of antibiotic side chain intermediates |
| CN102264744A (zh) * | 2008-12-25 | 2011-11-30 | 株式会社钟化 | 碳青霉烯侧链中间体的改良制造方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4321383A (en) * | 1980-11-24 | 1982-03-23 | E. R. Squibb & Sons, Inc. | Heterobicyclo intermediates |
| JP3091297B2 (ja) * | 1992-01-10 | 2000-09-25 | 住友製薬株式会社 | ピロリジン誘導体およびその製造方法 |
-
1996
- 1996-07-31 DE DE69610924T patent/DE69610924T2/de not_active Expired - Lifetime
- 1996-07-31 AU AU66439/96A patent/AU704304B2/en not_active Ceased
- 1996-07-31 PT PT96926210T patent/PT842166E/pt unknown
- 1996-07-31 DK DK96926210T patent/DK0842166T3/da active
- 1996-07-31 JP JP09508521A patent/JP3112952B2/ja not_active Expired - Fee Related
- 1996-07-31 CA CA002227696A patent/CA2227696C/en not_active Expired - Fee Related
- 1996-07-31 ES ES96926210T patent/ES2151671T3/es not_active Expired - Lifetime
- 1996-07-31 WO PCT/US1996/012552 patent/WO1997006154A1/en not_active Ceased
- 1996-07-31 EP EP96926210A patent/EP0842166B1/de not_active Expired - Lifetime
- 1996-07-31 AT AT96926210T patent/ATE197456T1/de not_active IP Right Cessation
-
2000
- 2000-11-09 GR GR20000402340T patent/GR3034795T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11510509A (ja) | 1999-09-14 |
| EP0842166B1 (de) | 2000-11-08 |
| ES2151671T3 (es) | 2001-01-01 |
| EP0842166A4 (de) | 1998-11-25 |
| WO1997006154A1 (en) | 1997-02-20 |
| CA2227696A1 (en) | 1997-02-20 |
| DK0842166T3 (da) | 2000-11-27 |
| PT842166E (pt) | 2001-04-30 |
| JP3112952B2 (ja) | 2000-11-27 |
| EP0842166A1 (de) | 1998-05-20 |
| AU704304B2 (en) | 1999-04-22 |
| DE69610924D1 (de) | 2000-12-14 |
| DE69610924T2 (de) | 2001-05-17 |
| AU6643996A (en) | 1997-03-05 |
| GR3034795T3 (en) | 2001-02-28 |
| CA2227696C (en) | 2003-09-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |