ATE185144T1 - Antimessenger oligonukleotide und urokinaserezeptor umkehrung des invasive phänotyps transformieter menschlicher fibroblasten durch antimessenger oligonukleotidinhibierung von urokinaserezeptoren-expression - Google Patents

Antimessenger oligonukleotide und urokinaserezeptor umkehrung des invasive phänotyps transformieter menschlicher fibroblasten durch antimessenger oligonukleotidinhibierung von urokinaserezeptoren-expression

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Publication number
ATE185144T1
ATE185144T1 AT95926907T AT95926907T ATE185144T1 AT E185144 T1 ATE185144 T1 AT E185144T1 AT 95926907 T AT95926907 T AT 95926907T AT 95926907 T AT95926907 T AT 95926907T AT E185144 T1 ATE185144 T1 AT E185144T1
Authority
AT
Austria
Prior art keywords
urocinal
antimessenger
receptor
oligonucleotide
pct
Prior art date
Application number
AT95926907T
Other languages
English (en)
Inventor
Sergio Capaccioli
Rosso Mario Del
Gabriella Fibbi
Alessandro Quattrone
Original Assignee
Consiglio Nazionale Ricerche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale Ricerche filed Critical Consiglio Nazionale Ricerche
Application granted granted Critical
Publication of ATE185144T1 publication Critical patent/ATE185144T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT95926907T 1994-07-22 1995-07-17 Antimessenger oligonukleotide und urokinaserezeptor umkehrung des invasive phänotyps transformieter menschlicher fibroblasten durch antimessenger oligonukleotidinhibierung von urokinaserezeptoren-expression ATE185144T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941560A IT1271684B (it) 1994-07-22 1994-07-22 Oligonucleotidi antisenso complementari all'rna messaggero del recettore umano della urochinasi

Publications (1)

Publication Number Publication Date
ATE185144T1 true ATE185144T1 (de) 1999-10-15

Family

ID=11369344

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95926907T ATE185144T1 (de) 1994-07-22 1995-07-17 Antimessenger oligonukleotide und urokinaserezeptor umkehrung des invasive phänotyps transformieter menschlicher fibroblasten durch antimessenger oligonukleotidinhibierung von urokinaserezeptoren-expression

Country Status (11)

Country Link
US (1) US5872106A (de)
EP (1) EP0772620B1 (de)
JP (1) JP3687919B2 (de)
AT (1) ATE185144T1 (de)
AU (1) AU3112395A (de)
DE (1) DE69512522T2 (de)
DK (1) DK0772620T3 (de)
ES (1) ES2136868T3 (de)
GR (1) GR3031985T3 (de)
IT (1) IT1271684B (de)
WO (1) WO1996003414A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994309A (en) 1997-07-25 1999-11-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions and methods
CA2357986C (en) * 1998-12-30 2014-02-11 Oligos Etc. Inc. Acid stable backbone modified end-blocked nucleic acids and therapeutic uses thereof
US20050048045A1 (en) * 2003-07-02 2005-03-03 Board Of Regents, The University Of Texas System Regulation of urokinase receptor expression by phosphoglycerate kinase
WO2017043490A1 (ja) * 2015-09-07 2017-03-16 協和発酵バイオ株式会社 自然免疫誘導効果が増強した二重鎖リボ核酸

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0467932T3 (da) * 1989-04-07 2001-02-12 Cancerforskningsfonden Af 1989 Plasminogen-aktivator-receptor af urokinasetypen

Also Published As

Publication number Publication date
EP0772620A1 (de) 1997-05-14
ES2136868T3 (es) 1999-12-01
AU3112395A (en) 1996-02-22
DE69512522D1 (de) 1999-11-04
JP3687919B2 (ja) 2005-08-24
IT1271684B (it) 1997-06-04
DE69512522T2 (de) 2000-01-13
ITMI941560A1 (it) 1996-01-22
EP0772620B1 (de) 1999-09-29
GR3031985T3 (en) 2000-03-31
JPH10502823A (ja) 1998-03-17
DK0772620T3 (da) 2000-03-27
US5872106A (en) 1999-02-16
ITMI941560A0 (it) 1994-07-22
WO1996003414A1 (en) 1996-02-08

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