ATE175999T1 - Verfahren zur regulierung von sialinsaeurederivaten in rekombinanten glykoproteinen - Google Patents

Verfahren zur regulierung von sialinsaeurederivaten in rekombinanten glykoproteinen

Info

Publication number
ATE175999T1
ATE175999T1 AT94932105T AT94932105T ATE175999T1 AT E175999 T1 ATE175999 T1 AT E175999T1 AT 94932105 T AT94932105 T AT 94932105T AT 94932105 T AT94932105 T AT 94932105T AT E175999 T1 ATE175999 T1 AT E175999T1
Authority
AT
Austria
Prior art keywords
sialic acid
regulating
acid derivatives
recombinant glycoproteins
cell culture
Prior art date
Application number
AT94932105T
Other languages
English (en)
Inventor
Tracy Kaye Blumen
Gustavo E Grampp
David Joseph Hettwer
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE175999T1 publication Critical patent/ATE175999T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT94932105T 1993-11-05 1994-10-28 Verfahren zur regulierung von sialinsaeurederivaten in rekombinanten glykoproteinen ATE175999T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14829893A 1993-11-05 1993-11-05

Publications (1)

Publication Number Publication Date
ATE175999T1 true ATE175999T1 (de) 1999-02-15

Family

ID=22525160

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94932105T ATE175999T1 (de) 1993-11-05 1994-10-28 Verfahren zur regulierung von sialinsaeurederivaten in rekombinanten glykoproteinen

Country Status (11)

Country Link
US (1) US5459031A (de)
EP (1) EP0734450B1 (de)
AT (1) ATE175999T1 (de)
AU (1) AU8095494A (de)
CA (1) CA2183552C (de)
DE (1) DE69416166T2 (de)
DK (1) DK0734450T3 (de)
ES (1) ES2126793T3 (de)
GR (1) GR3029499T3 (de)
HK (1) HK1008835A1 (de)
WO (1) WO1995012684A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
JP3269084B2 (ja) * 1992-06-10 2002-03-25 藤沢薬品工業株式会社 貧血治療のためのピラゾロピリジン化合物
EP0975673A2 (de) * 1997-04-21 2000-02-02 Glycozyme, Inc. Nachweis rekombinanter glykosylierter proteine und peptide in biologischen flüssigkeiten
AU744086B2 (en) * 1997-12-03 2002-02-14 Roche Diagnostics Gmbh Erythropoietin with high specific activity
EP2267026A1 (de) 2000-04-12 2010-12-29 Human Genome Sciences, Inc. Albuminfusionsproteine
ZA200306406B (en) 2001-01-19 2004-09-06 Dow Chemical Co Method for secretory production of glycoprotein having human-type sugar chain using plant cell.
US20030096281A1 (en) * 2001-09-14 2003-05-22 Ganesh Venkataraman Methods of making glycomolecules with enhanced activities and uses thereof
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
PT1463751E (pt) 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
AU2006324163B2 (en) 2005-12-08 2013-05-02 Amgen Inc. Improved production of glycoproteins using manganese
AU2008237632B2 (en) 2007-04-17 2014-01-16 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases
EP2325296A1 (de) 2009-11-20 2011-05-25 LEK Pharmaceuticals d.d. Herstellung von Glykoproteinen mit niedrigem N-Glykolylneuraminsäure-Gehalt (Neu5Gc-Gehalt)
MX2012011648A (es) 2010-04-07 2012-11-29 Momenta Pharmaceuticals Inc Glicanos de alta manosa.
US9170249B2 (en) 2011-03-12 2015-10-27 Momenta Pharmaceuticals, Inc. N-acetylhexosamine-containing N-glycans in glycoprotein products
EP2511293A1 (de) * 2011-04-13 2012-10-17 LEK Pharmaceuticals d.d. Verfahren zur Steuerung der Hauptkomplex-N-Glycan-Strukturen und der sauren Varianten und Variabilität in Bioprozessen, die rekombinante Proteine produzieren
EP2856159A4 (de) 2012-06-01 2016-04-13 Momenta Pharmaceuticals Inc Verfahren im zusammenhang mit denosumab
US10450361B2 (en) 2013-03-15 2019-10-22 Momenta Pharmaceuticals, Inc. Methods related to CTLA4-Fc fusion proteins
US10464996B2 (en) 2013-05-13 2019-11-05 Momenta Pharmaceuticals, Inc. Methods for the treatment of neurodegeneration
EP3058084A4 (de) 2013-10-16 2017-07-05 Momenta Pharmaceuticals, Inc. Sialylierte glycoproteine
WO2023086793A1 (en) 2021-11-09 2023-05-19 Amgen Inc. Production of therapeutic proteins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
US4954437A (en) * 1986-09-15 1990-09-04 Integrated Genetics, Inc. Cell encoding recombinant human erythropoietin
US5047335A (en) * 1988-12-21 1991-09-10 The Regents Of The University Of Calif. Process for controlling intracellular glycosylation of proteins
JP2657113B2 (ja) * 1989-10-16 1997-09-24 アムジエン・インコーポレーテツド 幹細胞因子
US5272070A (en) * 1991-03-08 1993-12-21 Board Of Regents, The University Of Texas System Method for the preparation of cell lines producing Man3 GlcNac 2 asparagine-linked gylcans and cell lines produced thereby

Also Published As

Publication number Publication date
CA2183552C (en) 2000-02-08
DK0734450T3 (da) 1999-09-13
US5459031A (en) 1995-10-17
EP0734450B1 (de) 1999-01-20
DE69416166D1 (de) 1999-03-04
DE69416166T2 (de) 1999-08-19
EP0734450A1 (de) 1996-10-02
GR3029499T3 (en) 1999-05-28
HK1008835A1 (en) 1999-05-21
ES2126793T3 (es) 1999-04-01
WO1995012684A1 (en) 1995-05-11
AU8095494A (en) 1995-05-23

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UEP Publication of translation of european patent specification
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