DE69416166T2 - Verfahren zur regulierung von sialinsaeurederivaten in rekombinanten glykoproteinen - Google Patents

Verfahren zur regulierung von sialinsaeurederivaten in rekombinanten glykoproteinen

Info

Publication number
DE69416166T2
DE69416166T2 DE69416166T DE69416166T DE69416166T2 DE 69416166 T2 DE69416166 T2 DE 69416166T2 DE 69416166 T DE69416166 T DE 69416166T DE 69416166 T DE69416166 T DE 69416166T DE 69416166 T2 DE69416166 T2 DE 69416166T2
Authority
DE
Germany
Prior art keywords
sialinic
regulating
derivatives
recombinant glycoproteins
cell culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69416166T
Other languages
English (en)
Other versions
DE69416166D1 (de
Inventor
Tracy Blumen
Gustavo Grampp
David Hettwer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of DE69416166D1 publication Critical patent/DE69416166D1/de
Application granted granted Critical
Publication of DE69416166T2 publication Critical patent/DE69416166T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
DE69416166T 1993-11-05 1994-10-28 Verfahren zur regulierung von sialinsaeurederivaten in rekombinanten glykoproteinen Expired - Lifetime DE69416166T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14829893A 1993-11-05 1993-11-05
PCT/US1994/012420 WO1995012684A1 (en) 1993-11-05 1994-10-28 Methods for controlling sialic acid derivatives in recombinant glycoproteins

Publications (2)

Publication Number Publication Date
DE69416166D1 DE69416166D1 (de) 1999-03-04
DE69416166T2 true DE69416166T2 (de) 1999-08-19

Family

ID=22525160

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69416166T Expired - Lifetime DE69416166T2 (de) 1993-11-05 1994-10-28 Verfahren zur regulierung von sialinsaeurederivaten in rekombinanten glykoproteinen

Country Status (11)

Country Link
US (1) US5459031A (de)
EP (1) EP0734450B1 (de)
AT (1) ATE175999T1 (de)
AU (1) AU8095494A (de)
CA (1) CA2183552C (de)
DE (1) DE69416166T2 (de)
DK (1) DK0734450T3 (de)
ES (1) ES2126793T3 (de)
GR (1) GR3029499T3 (de)
HK (1) HK1008835A1 (de)
WO (1) WO1995012684A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
ATE161178T1 (de) * 1992-06-10 1998-01-15 Fujisawa Pharmaceutical Co Pyrazolpyridine für die behandlung der anämie
WO1998047922A2 (en) * 1997-04-21 1998-10-29 Glycozyme, Inc. Determination of recombinant glycosylated proteins and peptides in biological fluids
ES2523599T3 (es) * 1997-12-03 2014-11-27 Roche Diagnostics Gmbh Eritropoyetina de gran actividad específica
CA2405709A1 (en) 2000-04-12 2001-10-25 Human Genome Sciences, Inc. Albumin fusion proteins
IL156879A0 (en) 2001-01-19 2004-02-08 Dow Chemical Co Method for secretory production of glycoprotein having human-type sugar chain using plant cell
US20030096281A1 (en) * 2001-09-14 2003-05-22 Ganesh Venkataraman Methods of making glycomolecules with enhanced activities and uses thereof
CA2471363C (en) 2001-12-21 2014-02-11 Human Genome Sciences, Inc. Albumin fusion proteins
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
CA2630811C (en) * 2005-12-08 2016-05-31 Amgen Inc. Improved production of glycoproteins using manganese
CA2684370C (en) 2007-04-17 2017-10-17 Plant Research International B.V. Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases
EP2325296A1 (de) 2009-11-20 2011-05-25 LEK Pharmaceuticals d.d. Herstellung von Glykoproteinen mit niedrigem N-Glykolylneuraminsäure-Gehalt (Neu5Gc-Gehalt)
MX2012011648A (es) 2010-04-07 2012-11-29 Momenta Pharmaceuticals Inc Glicanos de alta manosa.
EP2686671A4 (de) 2011-03-12 2015-06-24 Momenta Pharmaceuticals Inc N-acetylhexosamin-haltige n-glykane in glycoproteinprodukten
EP2511293A1 (de) * 2011-04-13 2012-10-17 LEK Pharmaceuticals d.d. Verfahren zur Steuerung der Hauptkomplex-N-Glycan-Strukturen und der sauren Varianten und Variabilität in Bioprozessen, die rekombinante Proteine produzieren
EP2856159A4 (de) 2012-06-01 2016-04-13 Momenta Pharmaceuticals Inc Verfahren im zusammenhang mit denosumab
US10450361B2 (en) 2013-03-15 2019-10-22 Momenta Pharmaceuticals, Inc. Methods related to CTLA4-Fc fusion proteins
EP2996772B1 (de) 2013-05-13 2018-12-19 Momenta Pharmaceuticals, Inc. Verfahren zur behandlung von neurodegeneration
EP3058084A4 (de) 2013-10-16 2017-07-05 Momenta Pharmaceuticals, Inc. Sialylierte glycoproteine
WO2023086793A1 (en) 2021-11-09 2023-05-19 Amgen Inc. Production of therapeutic proteins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
US4954437A (en) * 1986-09-15 1990-09-04 Integrated Genetics, Inc. Cell encoding recombinant human erythropoietin
US5047335A (en) * 1988-12-21 1991-09-10 The Regents Of The University Of Calif. Process for controlling intracellular glycosylation of proteins
HUT62011A (en) * 1989-10-16 1993-03-29 Amgen Inc Process for producing factors influencing the functioning of stem cells
US5272070A (en) * 1991-03-08 1993-12-21 Board Of Regents, The University Of Texas System Method for the preparation of cell lines producing Man3 GlcNac 2 asparagine-linked gylcans and cell lines produced thereby

Also Published As

Publication number Publication date
WO1995012684A1 (en) 1995-05-11
CA2183552C (en) 2000-02-08
EP0734450A1 (de) 1996-10-02
DE69416166D1 (de) 1999-03-04
HK1008835A1 (en) 1999-05-21
GR3029499T3 (en) 1999-05-28
EP0734450B1 (de) 1999-01-20
US5459031A (en) 1995-10-17
ATE175999T1 (de) 1999-02-15
ES2126793T3 (es) 1999-04-01
AU8095494A (en) 1995-05-23
DK0734450T3 (da) 1999-09-13

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