ATE154356T1 - Prozess und zwischenprodukte bei der darstellung von isoquinolinderivaten - Google Patents

Prozess und zwischenprodukte bei der darstellung von isoquinolinderivaten

Info

Publication number
ATE154356T1
ATE154356T1 AT92304314T AT92304314T ATE154356T1 AT E154356 T1 ATE154356 T1 AT E154356T1 AT 92304314 T AT92304314 T AT 92304314T AT 92304314 T AT92304314 T AT 92304314T AT E154356 T1 ATE154356 T1 AT E154356T1
Authority
AT
Austria
Prior art keywords
preparation
intermediate products
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
AT92304314T
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/703,969 external-priority patent/US5106978A/en
Priority claimed from GB929207634A external-priority patent/GB9207634D0/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of ATE154356T1 publication Critical patent/ATE154356T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT92304314T 1991-05-22 1992-05-13 Prozess und zwischenprodukte bei der darstellung von isoquinolinderivaten ATE154356T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/703,969 US5106978A (en) 1991-05-22 1991-05-22 Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors
GB929207634A GB9207634D0 (en) 1992-04-08 1992-04-08 Process and intermediate for the preparation of isoquinoline derivatives

Publications (1)

Publication Number Publication Date
ATE154356T1 true ATE154356T1 (de) 1997-06-15

Family

ID=26300672

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92304314T ATE154356T1 (de) 1991-05-22 1992-05-13 Prozess und zwischenprodukte bei der darstellung von isoquinolinderivaten

Country Status (13)

Country Link
EP (1) EP0519600B1 (de)
AT (1) ATE154356T1 (de)
AU (2) AU7765294A (de)
DE (1) DE69220291T2 (de)
DK (1) DK0519600T3 (de)
ES (1) ES2103890T3 (de)
FI (1) FI100330B (de)
GR (1) GR3024658T3 (de)
HK (1) HK1000321A1 (de)
HU (1) HU215589B (de)
IE (1) IE921641A1 (de)
NZ (1) NZ242856A (de)
SG (1) SG47769A1 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6317885A (ja) * 1986-07-11 1988-01-25 Kyorin Pharmaceut Co Ltd スピロピロリジン−２，５−ジオン誘導体の製造方法
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5106978A (en) * 1991-05-22 1992-04-21 American Home Products Corporation Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors

Also Published As

Publication number Publication date
HK1000321A1 (en) 1998-02-27
AU7765294A (en) 1995-01-12
ES2103890T3 (es) 1997-10-01
FI922291A0 (fi) 1992-05-20
IE921641A1 (en) 1992-12-02
AU4531797A (en) 1998-02-05
EP0519600A1 (de) 1992-12-23
HU9201692D0 (en) 1992-08-28
NZ242856A (en) 1994-08-26
FI922291A (fi) 1992-11-23
AU708608B2 (en) 1999-08-05
DE69220291T2 (de) 1998-01-29
GR3024658T3 (en) 1997-12-31
SG47769A1 (en) 1998-04-17
HUT61547A (en) 1993-01-28
DK0519600T3 (da) 1997-12-29
DE69220291D1 (de) 1997-07-17
EP0519600B1 (de) 1997-06-11
AU657325B2 (en) 1995-03-09
FI100330B (fi) 1997-11-14
AU1639792A (en) 1992-11-26
HU215589B (hu) 1999-01-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee