ATE148129T1 - Oligonukleotide synthese - Google Patents

Oligonukleotide synthese

Info

Publication number
ATE148129T1
ATE148129T1 AT93911532T AT93911532T ATE148129T1 AT E148129 T1 ATE148129 T1 AT E148129T1 AT 93911532 T AT93911532 T AT 93911532T AT 93911532 T AT93911532 T AT 93911532T AT E148129 T1 ATE148129 T1 AT E148129T1
Authority
AT
Austria
Prior art keywords
linker moiety
oligonucleotide
cleavable linker
cleavable
oligonucleotide synthesis
Prior art date
Application number
AT93911532T
Other languages
English (en)
Inventor
Michael Joseph Pillory Mclean
David Wardle Street Holland
Andrew John Peel Hall L Garman
Robert Charles Sheppard
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ATE148129T1 publication Critical patent/ATE148129T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT93911532T 1992-04-03 1993-04-02 Oligonukleotide synthese ATE148129T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929207381A GB9207381D0 (en) 1992-04-03 1992-04-03 Synthesis of oligonucleotides

Publications (1)

Publication Number Publication Date
ATE148129T1 true ATE148129T1 (de) 1997-02-15

Family

ID=10713445

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93911532T ATE148129T1 (de) 1992-04-03 1993-04-02 Oligonukleotide synthese

Country Status (12)

Country Link
US (2) US5393877A (de)
EP (1) EP0633891B1 (de)
JP (1) JPH07505290A (de)
AT (1) ATE148129T1 (de)
AU (1) AU674847B2 (de)
CA (1) CA2131994A1 (de)
DE (1) DE69307689T2 (de)
FI (1) FI109702B (de)
GB (1) GB9207381D0 (de)
NO (1) NO309482B1 (de)
RU (1) RU94042224A (de)
WO (1) WO1993020092A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9207381D0 (en) * 1992-04-03 1992-05-13 Ici Plc Synthesis of oligonucleotides
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5514789A (en) * 1994-04-21 1996-05-07 Barrskogen, Inc. Recovery of oligonucleotides by gas phase cleavage
US6025335A (en) * 1995-09-21 2000-02-15 Lipitek International, Inc. L-Nucleoside Dimer Compounds and therapeutic uses
EP0885236A1 (de) * 1996-01-26 1998-12-23 Codon Pharmaceuticals, Inc. Oligonukleotid-analoge
CA2268740C (en) 1996-11-06 2010-07-20 Sequenom, Inc. High density immobilization of nucleic acids
US6133436A (en) * 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US6046005A (en) * 1997-01-15 2000-04-04 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
IL131619A (en) * 1997-02-28 2002-12-01 Burstein Technologies Inc Laboratory on disk
US7427678B2 (en) * 1998-01-08 2008-09-23 Sigma-Aldrich Co. Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
ATE246041T1 (de) * 1998-02-11 2003-08-15 Univ Houston Office Of Technol Vorrichtung zur durchführung chemischer und biochemischer reaktionen unter anwendung von photoerzeugten reagenzien
US7094943B2 (en) 1998-04-27 2006-08-22 Hubert Köster Solution phase biopolymer synthesis
US6525185B1 (en) 1998-05-07 2003-02-25 Affymetrix, Inc. Polymorphisms associated with hypertension
US6319674B1 (en) 1999-09-16 2001-11-20 Agilent Technologies, Inc. Methods for attaching substances to surfaces
US6451998B1 (en) 1999-10-18 2002-09-17 Agilent Technologies, Inc. Capping and de-capping during oligonucleotide synthesis
CA2424716A1 (en) * 2000-09-05 2002-03-14 Shuyuan Yu Process for producing multiple oligonucleotides on a solid support
US6806051B2 (en) * 2000-09-25 2004-10-19 Picoliter Inc. Arrays of partially nonhybridizing oligonucleotides and preparation thereof using focused acoustic energy
US7635571B2 (en) * 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
US7211654B2 (en) * 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
US7098326B2 (en) * 2002-01-23 2006-08-29 Sigma-Aldrich Co. Methods for the integrated synthesis and purification of oligonucleotides
US6971790B2 (en) * 2002-10-11 2005-12-06 Welch Allyn, Inc. Thermometry probe calibration method
EP1585755B1 (de) * 2002-12-31 2015-08-05 Sigma-Aldrich Co. LLC Verfahren und zusammenstellungen für die tandem-synthese von zwei oder mehr oligonukleotiden auf einen festen träger
WO2005000859A2 (en) * 2003-04-14 2005-01-06 University Of Houston Novel reagent compounds and methods of making and using the same
WO2006063149A1 (en) 2004-12-09 2006-06-15 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
US20060286572A1 (en) * 2005-05-16 2006-12-21 Kohne David E Method for producing chemically synthesized and in vitro enzymatically synthesized nucleic acid oligomers
WO2008027558A2 (en) 2006-08-31 2008-03-06 Codon Devices, Inc. Iterative nucleic acid assembly using activation of vector-encoded traits
US20090036660A1 (en) * 2007-07-31 2009-02-05 Joel Myerson Methods and compositions for generating mixtures of nucleic acid molecules
US20090075840A1 (en) * 2007-09-18 2009-03-19 Joel Myerson Methods And Compositions For Generating Mixtures Of Nucleic Acid Molecules
US8808986B2 (en) 2008-08-27 2014-08-19 Gen9, Inc. Methods and devices for high fidelity polynucleotide synthesis
EP2346883B1 (de) * 2008-09-23 2016-03-23 Scott G. Petersen Selbstfreisetzende biolabile phosphatgeschützte pro-oligos für therapeutika auf oligonukleotidbasis und vermittlung von rna-interferenz
US10022454B2 (en) 2008-09-23 2018-07-17 Liposciences, Llc Functionalized phosphorodiamites for therapeutic oligonucleotide synthesis
US20120071358A1 (en) * 2008-12-04 2012-03-22 Xiaochuan Zhou Fluidic devices and methods for multiplex chemical and biochemical reactions
KR101141544B1 (ko) 2009-03-13 2012-05-03 한국과학기술원 에스아이알엔에이 다중 접합체 및 이의 제조방법
US10207240B2 (en) 2009-11-03 2019-02-19 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
US9216414B2 (en) 2009-11-25 2015-12-22 Gen9, Inc. Microfluidic devices and methods for gene synthesis
US9217144B2 (en) 2010-01-07 2015-12-22 Gen9, Inc. Assembly of high fidelity polynucleotides
WO2012064975A1 (en) 2010-11-12 2012-05-18 Gen9, Inc. Protein arrays and methods of using and making the same
JP6118725B2 (ja) 2010-11-12 2017-04-19 ジェン９・インコーポレイテッドＧｅｎ９，ＩＮＣ． 核酸合成のための方法およびデバイス
US9752176B2 (en) 2011-06-15 2017-09-05 Ginkgo Bioworks, Inc. Methods for preparative in vitro cloning
LT3594340T (lt) 2011-08-26 2021-10-25 Gen9, Inc. Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai
EP2766498B1 (de) 2011-10-14 2019-06-19 President and Fellows of Harvard College Sequenzierung durch strukturanordnung
WO2013123125A1 (en) 2012-02-17 2013-08-22 President And Fellows Of Harvard College Assembly of nucleic acid sequences in emulsions
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
US10081807B2 (en) 2012-04-24 2018-09-25 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
LT2864531T (lt) 2012-06-25 2019-03-12 Gen9, Inc. Nukleorūgšties konstravimo ir aukšto produktyvumo sekvenavimo būdai
US9476089B2 (en) 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes
KR20180039621A (ko) 2015-06-15 2018-04-18 엠펙 엘에이, 엘엘씨 정의된 다중 접합체 올리고뉴클레오티드
KR20240010750A (ko) 2017-02-06 2024-01-24 엠펙 엘에이, 엘.엘.씨. 감소된 신장 청소율을 갖는 다중결합 올리고뉴클레오티드

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067597A1 (de) * 1981-05-29 1982-12-22 ens BIO LOGICALS INC. Verfahren für Polynukleotidsynthese
US4775619A (en) * 1984-10-16 1988-10-04 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
GB9021625D0 (en) * 1990-10-04 1990-11-21 Ici Plc Synthesis of oligonucleotides
GB9207381D0 (en) * 1992-04-03 1992-05-13 Ici Plc Synthesis of oligonucleotides

Also Published As

Publication number Publication date
NO309482B1 (no) 2001-02-05
WO1993020092A1 (en) 1993-10-14
GB9207381D0 (en) 1992-05-13
DE69307689D1 (de) 1997-03-06
NO943660D0 (no) 1994-09-30
FI944568A0 (fi) 1994-09-30
NO943660L (no) 1994-09-30
EP0633891A1 (de) 1995-01-18
CA2131994A1 (en) 1993-10-14
US5552535A (en) 1996-09-03
JPH07505290A (ja) 1995-06-15
EP0633891B1 (de) 1997-01-22
FI944568A (fi) 1994-09-30
AU4042493A (en) 1993-11-08
FI109702B (fi) 2002-09-30
DE69307689T2 (de) 1997-05-15
RU94042224A (ru) 1996-07-20
AU674847B2 (en) 1997-01-16
US5393877A (en) 1995-02-28

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