ATE143360T1 - NEW PYRROLIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING SAME - Google Patents
NEW PYRROLIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING SAMEInfo
- Publication number
- ATE143360T1 ATE143360T1 AT92403404T AT92403404T ATE143360T1 AT E143360 T1 ATE143360 T1 AT E143360T1 AT 92403404 T AT92403404 T AT 92403404T AT 92403404 T AT92403404 T AT 92403404T AT E143360 T1 ATE143360 T1 AT E143360T1
- Authority
- AT
- Austria
- Prior art keywords
- products containing
- medicinal products
- production
- containing same
- pyrrolidine derivatives
- Prior art date
Links
- 229940126601 medicinal product Drugs 0.000 title abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- 102000003938 Thromboxane Receptors Human genes 0.000 abstract 1
- 108090000300 Thromboxane Receptors Proteins 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
Compounds of formula (I): (* CHEMICAL STRUCTURE *) (I) wherein R1, R2, R3, m, n, and R are as defined in the Specification. Medicinal products containing the same are useful in the treatment or prevention of thrombotic afflictions due to their thromboxane A2 receptor antagonistic activity and their thromboxane A2 synthase inhibitory activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9115851A FR2685325B1 (en) | 1991-12-20 | 1991-12-20 | NOVEL PYRROLIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE143360T1 true ATE143360T1 (en) | 1996-10-15 |
Family
ID=9420272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92403404T ATE143360T1 (en) | 1991-12-20 | 1992-12-15 | NEW PYRROLIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING SAME |
Country Status (13)
Country | Link |
---|---|
US (1) | US5296494A (en) |
EP (1) | EP0549407B1 (en) |
JP (1) | JPH0678302B2 (en) |
AT (1) | ATE143360T1 (en) |
AU (1) | AU651262B2 (en) |
CA (1) | CA2085570C (en) |
DE (1) | DE69214113T2 (en) |
DK (1) | DK0549407T3 (en) |
ES (1) | ES2094324T3 (en) |
FR (1) | FR2685325B1 (en) |
GR (1) | GR3021766T3 (en) |
NZ (1) | NZ245519A (en) |
ZA (1) | ZA929855B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2687146B1 (en) * | 1992-02-12 | 1994-04-01 | Adir Cie | NOVEL PYRROLIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
HUT69381A (en) * | 1993-12-09 | 1995-09-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing (2-chloro pyridyl)-7-azabicyclo [2.2.1.]heptane |
US5792776A (en) * | 1994-06-27 | 1998-08-11 | Cytomed, Inc., | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5856309A (en) * | 1994-10-14 | 1999-01-05 | Boehringer Mannheim Gmbh | Amidinopyrroline derivatives, processes for their production and pharmaceutical agents containing these compounds |
US6124341A (en) * | 1996-02-13 | 2000-09-26 | Abbott Laboratories | Endothelin antagonists |
TW575561B (en) * | 1999-03-25 | 2004-02-11 | Hoffmann La Roche | 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives |
WO2001089519A1 (en) * | 2000-05-22 | 2001-11-29 | Nitromed, Inc. | Thromboxane inhibitors, compositions and methods of use related applications |
CN103214407B (en) * | 2013-05-07 | 2015-11-18 | 北京大学 | Prepare the method for pyrrolidine derivative |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63295553A (en) * | 1987-05-01 | 1988-12-01 | Fujisawa Pharmaceut Co Ltd | Pyrrolidine derivative |
JPH0798795B2 (en) * | 1987-05-08 | 1995-10-25 | 塩野義製薬株式会社 | Sulfonamide-substituted unsaturated fatty acid |
EP0312906A3 (en) * | 1987-10-23 | 1990-09-05 | Ono Pharmaceutical Co., Ltd. | Novel sulfonamide derivatives |
US5130323A (en) * | 1988-10-31 | 1992-07-14 | Fujisawa Pharmaceutical Co., Ltd. | Pyrrolidine derivatives |
FR2687146B1 (en) * | 1992-02-12 | 1994-04-01 | Adir Cie | NOVEL PYRROLIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
-
1991
- 1991-12-20 FR FR9115851A patent/FR2685325B1/en not_active Expired - Fee Related
-
1992
- 1992-12-15 ES ES92403404T patent/ES2094324T3/en not_active Expired - Lifetime
- 1992-12-15 AT AT92403404T patent/ATE143360T1/en not_active IP Right Cessation
- 1992-12-15 DK DK92403404.4T patent/DK0549407T3/da active
- 1992-12-15 DE DE69214113T patent/DE69214113T2/en not_active Expired - Fee Related
- 1992-12-15 EP EP92403404A patent/EP0549407B1/en not_active Expired - Lifetime
- 1992-12-16 CA CA002085570A patent/CA2085570C/en not_active Expired - Fee Related
- 1992-12-17 AU AU30204/92A patent/AU651262B2/en not_active Ceased
- 1992-12-18 US US07/992,930 patent/US5296494A/en not_active Expired - Fee Related
- 1992-12-18 NZ NZ245519A patent/NZ245519A/en unknown
- 1992-12-18 ZA ZA929855A patent/ZA929855B/en unknown
- 1992-12-21 JP JP4340769A patent/JPH0678302B2/en not_active Expired - Lifetime
-
1996
- 1996-11-22 GR GR960403157T patent/GR3021766T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
JPH0678302B2 (en) | 1994-10-05 |
DK0549407T3 (en) | 1997-03-10 |
US5296494A (en) | 1994-03-22 |
EP0549407A1 (en) | 1993-06-30 |
DE69214113T2 (en) | 1997-04-10 |
JPH05262723A (en) | 1993-10-12 |
AU651262B2 (en) | 1994-07-14 |
FR2685325A1 (en) | 1993-06-25 |
CA2085570C (en) | 2001-10-23 |
GR3021766T3 (en) | 1997-02-28 |
EP0549407B1 (en) | 1996-09-25 |
ES2094324T3 (en) | 1997-01-16 |
AU3020492A (en) | 1993-06-24 |
ZA929855B (en) | 1994-01-13 |
NZ245519A (en) | 1994-08-26 |
DE69214113D1 (en) | 1996-10-31 |
FR2685325B1 (en) | 1994-02-04 |
CA2085570A1 (en) | 1993-06-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |