ATE135T1 - 2-substituierte-3-heterocycloindole, verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen. - Google Patents

2-substituierte-3-heterocycloindole, verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
ATE135T1
ATE135T1 AT79103669T AT79103669T ATE135T1 AT E135 T1 ATE135 T1 AT E135T1 AT 79103669 T AT79103669 T AT 79103669T AT 79103669 T AT79103669 T AT 79103669T AT E135 T1 ATE135 T1 AT E135T1
Authority
AT
Austria
Prior art keywords
substituted
heterocycloindols
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
AT79103669T
Other languages
German (de)
English (en)
Inventor
Martin Steinman
Pirouz Tahbaz
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE135T1 publication Critical patent/ATE135T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55Acids; Esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AT79103669T 1978-10-02 1979-09-27 2-substituierte-3-heterocycloindole, verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen. ATE135T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/947,979 US4225711A (en) 1978-10-02 1978-10-02 Substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles and their use as immunosuppressants
EP79103669A EP0010617B1 (en) 1978-10-02 1979-09-27 Novel 2-substituted-3-heterocyclylindoles, their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE135T1 true ATE135T1 (de) 1981-08-15

Family

ID=25487067

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79103669T ATE135T1 (de) 1978-10-02 1979-09-27 2-substituierte-3-heterocycloindole, verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Country Status (13)

Country Link
US (1) US4225711A (el)
EP (1) EP0010617B1 (el)
JP (1) JPS5566578A (el)
AT (1) ATE135T1 (el)
AU (1) AU526088B2 (el)
CA (1) CA1128944A (el)
DE (1) DE2960583D1 (el)
DK (1) DK411279A (el)
FI (1) FI793035A (el)
GR (1) GR73698B (el)
IL (1) IL58367A (el)
NZ (1) NZ191710A (el)
ZA (1) ZA795070B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
EP0350990B1 (en) * 1988-07-11 1995-09-20 Akzo Nobel N.V. Pyridazinone derivatives
PL209226B1 (pl) * 2000-10-17 2011-08-31 Ihara Chemical Ind Co Sposób wytwarzania podstawionego związku aniliny oraz związki pośrednie
ITMI20040874A1 (it) * 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori Derivati indolici ed azaindolici con azione antitumorale

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL23847A (en) * 1964-08-07 1969-02-27 Merck & Co Inc Benzimidazoles useful as antifungals
US3370063A (en) * 1964-10-05 1968-02-20 Mcneilab Inc Substituted dimethoxy indoles and method of making the same
DE1695647A1 (de) * 1967-09-01 1971-05-13 Rhein Pharma Arzneimittel Gmbh 3-Pyridyl(4)-indole und Verfahren zu ihrer Herstellung
US3927023A (en) * 1974-05-24 1975-12-16 Warner Lambert Co Imidazolyl benzofurans
GB1523276A (en) * 1974-09-20 1978-08-31 Lafon Labor Sulphur-containing amino compounds
US4059583A (en) * 1975-11-13 1977-11-22 Mcneil Laboratories, Incorporated Substituted indoles

Also Published As

Publication number Publication date
EP0010617A1 (en) 1980-05-14
DK411279A (da) 1980-04-03
EP0010617B1 (en) 1981-08-05
JPS6345386B2 (el) 1988-09-09
AU5134579A (en) 1980-04-17
JPS5566578A (en) 1980-05-20
NZ191710A (en) 1984-04-27
FI793035A (fi) 1980-04-03
IL58367A0 (en) 1980-01-31
CA1128944A (en) 1982-08-03
IL58367A (en) 1984-05-31
US4225711A (en) 1980-09-30
GR73698B (el) 1984-04-03
DE2960583D1 (en) 1981-11-05
AU526088B2 (en) 1982-12-16
ZA795070B (en) 1981-05-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee